Biomaterials for 3D Tumor Modeling reviews the fundamentals and most relevant areas of the latest advances of research of 3D cancer models, focusing on biomaterials science, tissue engineering, drug delivery and screening aspects. The book reviews advanced fundamental topics, including the causes of cancer, existing cancer models, angiogenesis and inflammation during cancer progression, and metastasis in 3D biomaterials. Then, the most relevant biomaterials are reviewed, including methods for engineering and fabrication of biomaterials. 3D models for key biological systems and types of cancer are also discussed, including lung, liver, oral, prostate, pancreatic, ovarian, bone and pediatric cancer.
This book is suitable for those working in the disciplines of materials science, biochemistry, genetics, molecular biology, drug delivery and regenerative medicine.
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Table of Contents
1. Trends in biomaterials for 3D cancer modeling2. Causes of cancers: physical, chemical, biological carcinogens and viruses3. Three-dimensional in vitro models of angiogenesis4. Metastasis in 3D biomaterials5. Biomatrices that mimic the cancer extracellular environment6. Marine derived biomaterials for cancer treatment7. 3D scaffold materials for skin cancer modeling8. Three-dimensional tumor model and their implication in drug screening for tackling chemoresistance9. In vitro 3D modelling for prostate cancer10. Biomaterial based in vitro models for pancreatic cancer11. Mesoporous silica nanoparticles for cancer theranostics applications12. Microfluidic systems in cancer research13. Bio-detection and sensing for cancer diagnostics14. Biomaterials as ECM-like matrices for 3D in vitro tumor models15. 3D cancer spheroids and microtissues16. Co-culture and 3D tumor models for drug and gene therapy testing17. Engineering of 3D in vitro models for cancer research18. Tissue engineered 3D cancer microenvironment for screening therapeutics19. 3D neuroblastoma models using engineered cell-derived matrices20. 3D cancer models for chemotherapy using biomaterials21. 3D tumor-on-chip devices with perfusion for anti-cancer drug testing22. A predictive oncology framework: Modelling tumor proliferation using a FEM platform23. Understanding the impact of controlled oxygen delivery to 3D cancer cell culture24. 3D full skin models for skin cancer research25. Tissue engineering strategies for treatment of skeletal maxillofacial defects resulting from neoplasms resections26. 3D culture systems as models for solid tumors and cancer metabolism27. Biofabrication of 3D tumor models in cancer research28. Engineering breast cancer models in vitro with 3D printing
