Demineralized Bone Matrix Market - Growth, Trends, COVID-19 Impact, and Forecasts (2023-2028)

The demineralized bone matrix market is expected to register a CAGR of 5.5% over the forecast period.

Delays in orthopedic care and services during the COVID-19 pandemic adversely impacted the market. According to the NCBI research study published in August 2021, orthopedic residency training was postponed or canceled during the pandemic. The inevitable halting of all elective surgeries has limited hands-on practice and exposure to several procedures. Although the orthopedic oncology service has continued, it is a limited area within the orthopedic training program, including at least nine sub-specialties. Trauma surgery continued but at a much slower rate, most likely due to the nationwide lockdown, which had a short-term negative impact on the market. In March 2020, the International Olympic Committee postponed the 2020 Tokyo Olympics and Paralympics to 2021. According to the COVIDSurg Collaborative, a research initiative by 120 countries, 28.4 million elective surgeries were reported to have been canceled in 2020, including 6.3 million orthopedic surgeries. However, with a decrease in the number of cases of COVID-19 and the resumption of various healthcare services, the market gained traction and is anticipated to continue its upward trend over the forecast period.

Factors such as the increasing incidence of orthopedic disorders, the rising number of spinal fusion and dental surgeries, and the increasing patient base with a growing population are expected to drive the market's growth. For instance, according to the WHO Key Facts on Musculoskeletal Health published in July 2022, around 1.71 billion people worldwide had musculoskeletal conditions. In Europe, the International Osteoporosis Foundation (IOF) is responsible for raising awareness of osteoporosis care in Europe. According to an article published by the National Institute of Health, in 2021, the incidence of osteoarthritis in the United Kingdom was 6.8 per 1,000 people, whereas the prevalence was around 10.7% in 2021. Thus, such a high prevalence of orthopedic disorders is expected to propel the demand for demineralized bone matrix, as it one of the important therapeutic options for such conditions.

As per the Australian Institute of Health and Welfare's article on chronic musculoskeletal conditions published in July 2022, around 6.9 million people in Australia were affected by musculoskeletal disorders during 2020-2021. Over 3.1 million people had arthritis, and more than 889 thousand people had osteoporosis. According to the US CDC article on arthritis, updated in October 2021, around 58.5 million people in the nation had doctor-diagnosed arthritis. The article estimated that, by 2040, over 78.4 million adults in the United States will be affected by arthritis. Thus, owing to such factors, considerable market growth is expected over the forecast period.

However, the high cost of demineralized bone matrix is expected to hinder the market's growth over the forecast period.

Key Market Trends

Spinal Fusion Segment is Anticipated to Witness Significant Growth During the Forecast Period

Spinal fusion is used to correct defects in the vertebrae of the spine. Spinal fusion is a surgical procedure used to correct problems with the small bones in the spine (vertebrae). It is essentially a welding process, majorly used to fuse two or more vertebrae to help them heal into a single, solid bone. It is done to eliminate painful motion or to restore stability to the spine. Spinal fusion eliminates motion between vertebrae and prevents the stretching of nerves and surrounding ligaments and muscles. It is an option when motion is the source of pain, such as movement that occurs in a part of the spine that is arthritic or unstable due to injury, disease, or the normal aging process.

The increasing number of elderly suffering from these spinal disorders and the rising adoption of demineralized bone matrix procedures as a treatment method are anticipated to propel the segment's growth over the forecast period. For instance, as per the data from World Population Prospects: The 2021 Revision published by the United Nations, the number of older people aged 65 years or above is expected to more than double by 2050 globally, rising from 727 million in 2020 to 1.5 billion in 2050. According to the Census Bureau’s 2020 population estimates, the number of Americans aged 65 or older exceeds 55 million. Three states, namely, California, Florida, and Texas, are home to one-fourth of these senior citizens. According to the CDC update, in October 2021, about 1 in four US adults (23.7%) or about 58.5 million people have doctor-diagnosed arthritis. The rising funding for the development of products used in spine fusion surgeries is expected to drive the growth of the segment over the forecast period. In October 2021, Intelligent Implants raised EUR 7.5 million (USD 8.7 million) to make spinal surgery less painful. The company’s smart implants’ first application is in spinal fusion surgery, where two or more vertebrae are permanently connected to improve stability, correct a deformity, or reduce pain. Intelligent Implants use wireless implantable electronics to stimulate, steer, and monitor bone growth.

Therefore, owing to favorable initiatives and the increasing geriatric population, the segment is anticipated to witness significant growth over the forecast period.

North America is Expected to Witness Considerable Growth During the Forecast Period

North America is expected to witness considerable growth over the forecast period, owing to the increasing prevalence of spinal injuries, orthopedic disorders, and a rising geriatric population in the region. For instance, as per the PLOS research study published in May 2022, each year, approximately 17,000 new cases of spinal cord injury (SCI) are reported in the United States, with an estimated 282,000 people living with SCI. Men report the majority of SCI caused by a sports injury. The age group from 16 to 30 years old has the highest risk of SCI. According to a research report published in November 2021, Clinical Practice Guidelines (CPGs) are crucial for giving patients the best care possible. SCI causes a complex constellation of impairments that call for tertiary care across the health system and the individual's lifetime. The Can-SCIP Guideline, which has incorporated recommendations from 41 other guidelines and evaluated the content of the guidelines for implementation in Canada, is the first comprehensive guideline for adults with SCI in the country. Thus, with the growing prevalence of bone-related diseases and spinal injuries, considerable market growth is expected in North America.

Key product launches, high concentration of market players or manufacturers, acquisitions and partnerships among major players, and an increasing number of spine surgeries in the United States are some of the factors driving the growth of the demineralized bone matrix market in the country. For instance, according to the NCBI research study published in December 2021, fusion surgery is one of the most common surgical procedures for the spine. Annually, approximately 400,000 spinal fusions are performed in the United States, with estimated costs of USD 32.0 billion. Various standard guidelines have been introduced in the region to provide better care to spinal cord injury patients. Therefore, significant market growth is expected in the country over the forecast period.

Competitive Landscape

The market is characterized by high competition based on price, product differentiation, and low cost of technology. It is also marked by an increased focus on the development of innovative products and a successful track record of mergers and acquisitions. Major manufacturers, raw material suppliers, and machinery manufacturers have been working in tandem to research, develop, and innovate new products within the field of allograft. Some of the key industry players are Johnson & Johnson (Depuy Synthes), Medtronic, AlloSource, Zimmer Biomet, and Stryker.

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