Genetics, Neurology, Behavior, and Diet in Parkinson's Disease. The Neuroscience of Parkinson's Disease, Volume 2

Table of Contents

Part I: Genetics, molecular and cellular biology

2. Alpha-synuclein gene and Parkinson's diseaseAthina-Maria Simitsi, Chistos Koros and Leonidas Stefanis

3. The DJ-1 gene and protein: links with Parkinson's diseaseVanessa J. Musco, Sarah J. Annesley and Paul R. Fisher

4. Regulation of tyrosine hydroxylase: relevance to Parkinson's diseaseGelareh Alam and Jason R. Richardson

5. Linking glucocerebrosidase gene (GBA) variants and Parkinson's diseasectoria Berge-Seidl and Mathias Toft

6. Astrocytes and microglia in Parkinson's disease and animal modelsKatarzyna Kuter

7. The role of autophagy in Parkinson's disease etiopathogenesisEmanuel Candeias, J�ao Duarte Magalh�es, Daniel Santos, Helena Costa, Diana F. Silva, Ana Raquel Esteves and Sandra Morais Cardoso

8. The mitochondrial network in Parkinson's diseaseAndreas Aufschnaiter, Verena Kohler and Sabrina B�ttner

9. Signal transduction in Parkinson's disease: modulation of neurotransmission, symptomatology, and therapyMattia Volta

10. Oxidative stress signaling and regulated cell death in Parkinson's diseaseCarlos Velez-Pardo and Marlene Jimenez-Del-Rio

11. Subcellular-specific alpha-synuclein in Parkinson's diseaseBenjamin Rosen, Ketan S. Patil, Guido W. Alves and Simon G. M�ller

12. Melanocortin 1 receptor: Parkinson's disease, melanoma risk, and neuroprotectionGemma Tell-Marti, Joan Anton Puig-Butill� and Susana Puig

13. Energy regulation and Parkinson's diseaseLiting Hang and Kah-Leong Lim

14. Linking rotigotine, Parkinson's disease, and brain-derived neurotrophic factorKazuhiro Sohya, Kazunori O'Hashi and Hiroshi Kunugi

Part II: Neurology, physiology and imaging

15. The different syndromes in Parkinson's disease: an overviewNikolaos Giagkou and Maria Stamelou

16. Neuromolecular imaging in Parkinson's diseasePatricia A. Broderick and Leslie Wenning

17. Interlinking brain mapping and Parkinson's disease: MRI analysis, nigrosome 1 and nigrosome 4Eung Yeop Kim, Young Hee Sung and Jongho Lee

18. Interconnecting Parkinson's disease: the use of computed tomography and microelectrode recording in DBS surgeryRyan B. Kochanski and Sepehr Sani

19. Linking diffusion tensor imaging, microstructures and Parkinson's diseaseYu Zhang, Norbert Schuff, I-Wei Wu and Duygu Tosun

20. Detecting parkinsonian degeneration in lateroventral tier of substantia nigra pars compacta with MRIJason Langley, Daniel E. Huddleston and Xiaoping P. Hu

21. Vagal motoneurons in Parkinson's diseaseRuth E. Musgrove, Wei-Hua Chiu and Joshua A. Goldberg

22. Circadian clock disruption and neuroinflammation in Parkinson's disease: a new perspective Elisabetta Lauretti and Domenico Pratic�

23. Motor cortex stimulation in Parkinson's diseaseAngelo Lavano, Giusy Guzzi, Attilio Della Torre and Domenico La Torre

24. Action programming disorders associated with Parkinson's diseaseKenneth M. Heilman

25. The striatal medium spiny neurons: what they are and how they link with Parkinson's diseaseFu-Ming Zhou

26. Disruptions of frontostriatal language functions in Parkinson's diseaseAdolfo M. Garc�a, Yamile Bocanegra, Agustina Birba, Juan Rafael Orozco-Arroyave, Lucas Sede�o and Agust�n Iba�ez

27. Alpha-synuclein and neuroinflammation in Parkinson's diseaseTatiana Varanita and Luigi Bubacco

28. Tau and its interactions with other proteins in neurodegenerative diseasesKatelyn H. Mroczek, Sarah J. Annesley and Paul R. Fisher

29. Interaction between brain angiotensin and dopaminergic systems and Parkinson's diseaseJose Luis Labandeira-Garcia, Pablo Garrido-Gil, Maria A. Pedrosa, Carmen M. Labandeira and Ana I. Rodriguez-Perez

30. Restoring dopamine levels in Parkinson's disease: neuronal pathways, agonists and antiinflammatory agents�gatha Oliveira-Giacomelli, C.M. Albino, Hellio Danny N�brega de Souza and Henning Ulrich

Part III: Behaviour and psychopathology

31. Motivation and motivational aspects of Parkinson's diseaseAbdeslam Chagraoui, Emilie Puginier and Philippe De Deurwaerd�re

32. Linking anxiety, cognitive and sensory deficits to gait and balance deficits in Parkinson's diseaseQuincy J. Almeida

33. Motor programs interlinking gait and bradykinesia in Parkinson's diseaseTateo Warabi, Kiyoharu Inoue and Nobuo Yanagisawa

34. Olfactory disturbances in Parkinson's diseaseLais S. Rodrigues, Juliane Fagotti, Adriano D.S. Targa, Ana Carolina D. Noseda, Jessica L. Ilkiw, Flavia W.C. Dorieux and Marcelo M.S. Lima

35. Interlinking dementia in Parkinson's disease: nutritional correlates of body compositionArthur Oscar Schelp, J�ssica Emy Komuro, Jos� Eduardo Corrente and Silvia Justina Papini

36. The role of the gastrointestinal system and gut microbiota in Parkinson's diseaseJade Kenna and Ryan S. Anderton

37. Swallowing impairment in Parkinson's diseaseMaira Rozenfeld Olchik, Marina Padovani and Annelise Ayres

38. The Mini Nutritional Assessment (MNA) and applications to Parkinson's diseaseSvetlana Tomic

39. The efficacy of Bacopa monnieri extract in modulating Parkinson's diseaseDr. Ravikumar Hosamani

Part V: Models, modelling and resources

40. 6-hydroxydopamine-induced model of Parkinson's diseaseKatarzyna Kaczynska and Kryspin Andrzejewski

41. Knockdown transgenic Drosophila and Parkinson's diseaseMarlene Jimenez-Del-Rio and Carlos Velez-Pardo

42. Neuroprotection in animal models of Parkinson's disease: exploring exercise, sound, and lightJohn Mitrofanis

43. Modeling with the A53T a-synuclein model of Parkinson's diseaseThomas Musacchio, James B. Koprich and Chi Wang Ip

44. Linking the leucine-rich repeat kinase 2 gene, animal models, and Parkinson's diseaseYulan Xiong and Jianzhong Yu

45. Neuroscience of Parkinson's disease: recommended reading and resourcesRajkumar Rajendram, Vinood B. Patel and Victor R. Preedy

Authors

Colin R Martin Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director: Institute for Health and Wellbeing, University of Suffolk, Ipswich, UK. Colin R. Martin RN, BSc, MSc, PhD, MBA, YCAP, FHEA, C.Psychol, AFBPsS, C.Sci is Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director of the Institute of Health and Wellbeing at the University of Suffolk, UK. He is a Chartered Health Psychologist and a Chartered Scientist. He also trained in analytical biochemistry, this aspect reflecting the psychobiological focus of much of his research within mental health. He has published or has in press well over 300 research papers and book chapters. He is a keen book author and editor having written and/or edited more than 50 books. These outputs include the prophetic insight into the treatment of neurological disease, Handbook of Behavior, Food and Nutrition (2011), Nanomedicine and the Nervous System (2012), Oxidative Stress and Dietary Antioxidants in Neurological Disease (2020), Zika Virus Impact, Diagnosis, Control and Models (2021), Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior and Diet (2021), Diagnosis and Treatment of Spinal Cord Injury (2022), The Neurobiology, Physiology, and Psychology of Pain (2022) and The Handbook of Lifespan Cognitive Behavioral Therapy: Childhood, Adolescence, Pregnancy, Adulthood, and Aging (2023). Professor Martin is particularly interested in all aspects of the relationship between underlying physiological substrates and behavior, particularly in how these relationships manifest in both acute and chronic psychiatric disorder. He has published original research germane to significant mental health disorders including the areas of schizophrenia, anxiety, depression, self-esteem, alcohol and drug dependency, high secure forensic mental health and personality disorder. He has a keen interest in the impact of postviral illness and is actively involved in clinical research post-Covid pandemic and in particular, the impact of Long Covid on psychological, neurological, physiological and social functioning. He is involved in collaborative International research with many European and Non-European countries. Victor R Preedy Professor, Department of Clinical Biochemistry, King's College Hospital, London, UK; Emeritus Professor, Faculty of Life Sciences and Medicine, King's College London, UK Visiting Professor, University of Hull, UK. Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRSC, FRCPath graduated with an Honours Degree in Biology and Physiology with Pharmacology. After gaining his University of London PhD, he received his Membership of the Royal College of Pathologists. He was later awarded his second doctorate (DSc), for his contribution to protein metabolism in health and disease. He is Professor of Clinical Biochemistry (Hon) at King's College Hospital and Emeritus Professor of Nutritional Biochemistry at King's College London. He has Honorary Professorships at the University of Hull, and the University of Suffolk. Professor Preedy was the Founding Director and then long-term Director of the Genomics Centre at King's College London from 2006 to 2020. Professor Preedy has been awarded fellowships of the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health, the Royal Society for Public Health, the Royal Society of Chemistry and the Royal Society of Medicine. He carried out research when attached to the National Heart Hospital (part of Imperial College London), The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with international research groups in Finland, Japan, Australia, USA, and Germany. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and edited books.