The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials.
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Table of Contents
Part 1. Fundamentals of quadruplexes and their biology- Fundamentals of G-quadruplex biology
F. Brad Johnson
- Quadruplex structure and diversity
Fernaldo Richtia Winnerdy and Anh Tu?n Phan
Part 2. Quadruplex targets in human and other organisms
- Telomeric quadruplexes as therapeutic targets
Sefan Asamitsu, Norifumi Shioda and Hiroshi Sugiyama
- Viral G-quadruplexes: New frontiers in virus pathogenesis and antiviral therapy
Emanuela Ruggiero and Sara N. Richter
- Quadruplex detection in human cells
David Monchaud
Part 3. Discovery and design of quadruplex-binding compounds
- An overview of quadruplex ligands: Their common features and chemotype diversity
Valentina Pirota, Michele Stasi, Alessandra Benassi and Filippo Doria
- Molecular dynamics simulations of G-quadruplexes: The basic principles and their application to folding and ligand binding
Jiri Sponer, Barira Islam, Petr Stadlbauer and Shozeb Haider
- Quadruplex-interacting compounds for regulating the translation of the Epstein-Barr virus nuclear antigen 1 (EBNA1) mRNA: A new strategy to prevent and treat EBV-related cancers
Anton Granzhan, Rodrigo Prado Martins, Robin F?hraeus, Marc Blondel and Marie-Paule Teulade-Fichou
- Click and combinatorial approaches to quadruplex ligand discovery
Jyotirmayee Dash, Puja Saha and Khushnood Fatma
- Quadruplex nucleic acids in KRAS targeted-cancer therapy
Luigi E. Xodo
- Transcriptional regulation of MYC through G-quadruplex structures
Sumirtha Balaratnam and John S. Schneekloth
- KIT promoter: Structure, function and targeting
Silvia Ceschi and Claudia Sissi
- Quadruplex targets in neurodegenerative diseases
Janez Plavec
- Metal complexes as G-quadruplex binders
Tim Kench and Ramon Vilar
- Challenges in developing small-molecule quadruplex therapeutics
Stephen Neidle
