Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy.
Cancer researchers, oncologists, pharmacologists and several members of biomedical field who are interested in learning more about the use of existing drugs for different purposes in cancer therapy will find this to be a valuable resource.
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Table of Contents
1. Drug repurposing for cancer therapydan introduction2. A ligand-centric approach to identify potential drugs for repurposing: case study with aurora kinase inhibitors3. Machine learning strategies for identifying repurposed drugs for cancer therapy4. Unveiling potential anticancer drugs through in silico drug repurposing approaches5. Increasing opportunities of drug repurposing for treating breast cancer by the integration of molecular, histological, and systemic approaches6. The success story of drug repurposing in breast cancer7. A personalized medicine approach to drug repurposing for the treatment of breast cancer molecular subtypes8. Successful stories of drug repurposing for cancer therapy in hepatocellular carcinoma9. Stories of drug repurposing for pancreatic cancer treatmentdPast, present, and future 10. Animal models and in vivo investigations for drug repurposing in lung cancer11. Identification of chemosensitizers by drug repurposing to enhance the efficacy of cancer therapy12. Drugs repurposed to potentiate immunotherapy for cancer treatment13. Nanoparticle-based formulation for drug repurposing in cancer treatment14. Nanotechnological approaches in cancer: the role of celecoxib and disulfiram15. Clinical trials on combination of repurposed drugs and anticancer therapies
Authors
Kenneth K.W. To Associate Professor, Chinese University of Hong Kong.
Prof. Kenneth To is currently an Associate Professor in the Chinese University of Hong Kong. He received post-doctoral training at the National Cancer Institute, National Institute of Health, USA, investigating the mechanisms of multidrug resistance and cancer epigenetics. After he became an independent investigator, his research interests focus on the development of novel strategies to overcome drug resistance to classical cytotoxic anticancer drugs as well as molecular targeted cancer therapeutics. He has served as Guest Associate Editor (Frontiers in Oncology & Frontiers in Genetics), Consulting Editor (Pharmacology Research and Perspectives) and Editorial Board Member in 4 other journals in the fields of cancer research and pharmacology. He published more than 100 peer-reviewed articles in highly ranked scientific journals in cancer biology and pharmacology.
William C.S. Cho Queen Elizabeth Hospital, Hong Kong.
William C.S. Cho, PhD, RCMP, FHKIMLS, FHKSMDS, Chartered Scientist (UK), FIBMS (UK). Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong SAR, China. Dr. Cho's primary research interests focus on cancer research to discover biomarkers for cancer diagnosis, treatment prediction, and prognosis. As a seasoned researcher, Dr. Cho has conducted cancer research using molecular biology, proteomics, genomics, immunology, bioinformatics, and next-generation sequencing technologies. Dr. Cho has published more than 600 peer-reviewed papers (Lancet, Lancet Oncology, Annals of Oncology, Lancet Gastroenterology & Hepatology, Advanced Science, Nature Communications, PNAS, Molecular Cancer, Journal of Thoracic Oncology, Journal of the National Cancer Institute, Journal of Extracellular Vesicles, Clinical Cancer Research, Clinical Chemistry, Theranostics, etc.) covering cancer biomarkers, proteomics, noncoding RNA, traditional Chinese medicine, and dozens of books (including An Omics Perspective on Cancer Research, MicroRNAs in Cancer Translational Research, Drug Repurposing in Cancer Therapy: Approaches and Applications, Supportive Cancer Care with Chinese Medicine, etc.). The cumulative impact factor of journals exceeds 4000, and the papers have been cited >25,000 times. Dr. Cho is listed among the top 2% of the most influential scientists in the world. In addition, Dr. Cho has served as a research grant reviewer for many international research funds, including the Hope Funds for Cancer Research (United States), Cancer Research (United Kingdom), National Medical Research Council (Singapore), etc.
