Biology of Aminoacyl-tRNA Synthetases, Volume 48 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on A narrative about our work on the endless frontier of editing, The puzzling evolution of aminoacyl-tRNA synthetases, Structural basis of the tRNA recognition by aminoacyl-tRNA synthetases, Catalytic strategies of aminoacyl-tRNA synthetases, Trans-editing by aminoacyl-tRNA synthetase-like editing domains, Adaptive and maladaptive mistranslation arising from aminoacyl-tRNA synthetases, Non-canonical inputs and outputs of tRNA aminoacylation, Structure and function of multi-tRNA synthetase complexes, Mitochondrial aminoacyl-tRNA synthetases, Non-canonical functions of human cytoplasmic tyrosyl-, tryptophanyl- and other aminoacyl-tRNA synthetases, and much more.
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Table of Contents
1. The endless frontier of tRNA synthetasesPaul Schimmel
2. The evolution of aminoacyl-tRNA synthetases: From dawn to LUCA
Llu?s Ribas de Pouplana
3. Putting amino acids onto tRNAs: The aminoacyl-tRNA synthetases as catalysts
Rebecca W. Alexander and Tamara L. Hendrickson
4. Trans-editing by aminoacyl-tRNA synthetase-like editing domains
Alexandra B. Kuzmishin Nagy, Marina Bakhtina and Karin Musier-Forsyth
5. Noncanonical inputs and outputs of tRNA aminoacylation
Marine Hemmerle, Marion Wendenbaum, Guillaume Grob, Nathaniel Yakobov, Nassira Mahmoudi, Bruno Senger, Sylvain Debard, Fr?d?ric Fischer and Hubert Dominique Becker
6. Structures and functions of multi-tRNA synthetase complexes
Myung Hee Kim and Sunghoon Kim
7. Mitochondrial aminoacyl-tRNA synthetases
Joseph Chihade
8. Non-canonical functions of human tytoplasmic tyrosyl-, tryptophanyl- and other aminoacyl- tRNA synthetases
Keisuke Wakasugi and Takumi Yokosawa
9. Aminoacyl-tRNA synthetases in cell signaling
Peng Yao and Paul L. Fox
10. Human diseases linked to cytoplasmic aminoacyl-tRNA synthetases
Lei Jiang, Julia Jones and Xiang-Lei Yang
11. Aminoacyl-tRNA synthetases as drug targets
Maria Lukarska and Andr?s Palencia
12. Engineering aminoacyl-tRNA synthetases for use in synthetic biology
Natalie Krahn, Jeffery Tharp, Ana Crnkovic and Dieter S?ll
13. Novel functions of cytoplasmic aminoacyl-tRNA synthetases shaping the hallmarks of cancer
Justin Wang and Xiang-Lei Yang
