Frontiers in Clinical Drug Research - Dementia is a book series which presents comprehensive reviews about research on Dementia, - the loss of brain function associated with Alzheimer’s diseases and other related conditions. The disease affects the parts of the brain that deal with memory, thought, and language.
Chapters in each volume focus on drug research with special emphasis on clinical trials, research on drugs in advanced stages of development and cure for dementia and related disorders.
This volume includes the following reviews:
- Meeting the Challenges of Falls and Hip Fractures in People with Alzheimer’s Disease
- Cholesterol in Brain Health and Pathologies
- Advances in Treatment of Mild Cognitive Impairment (MCI) and Dementia
- Analytical Methods in Alzheimer’s Disease Drug Discovery
- Targeting Alzheimer’s Disease through Nanomedicine
- Current Challenges in Alzheimer’s Disease Research
- Metals Linked to Alzheimer's Disease
Frontiers in Clinical Drug Research - Dementia will be of particular interest to readers interested in drug therapy of this specific neurodegenerative condition and related brain disorders as the series provides relevant reviews written by experts in the field.
Table of Contents
Chapter 1 Meeting the Challenges of Falls and Hip Fractures in People with Alzheimer’s Disease
- Kareeann Sok Fun Khow and Tuck Yean Yong
- Introduction
- Risk Factors for Falls in Alzheimer’s Disease
- Common Risk Factors for Alzheimer’s Disease and Hip Fractures
- Hip Fracture and Cognitive Decline
- Preventing and Managing Hip Fractures in Alzheimer’s Disease
- Primary Prevention of Falls and Hip Fractures
- Falls Prevention
- Managing and Preventing Osteoporosis
- Acute Treatment of Hip Fractures
- Orthogeriatric Model of Care
- Timing of Surgery
- Prevention of Delirium
- Adequate Analgesia
- Early Mobilization
- Surgery in Severe Alzheimer’s Disease
- Post-Acute Care
- Rehabilitation
- Preventing Recurrent Falls
- Treatment of Osteoporosis
- Management of Depression
- Gaps in Current Evidence and Future Research
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 2 Cholesterol in Brain Health and Pathologies: the Role In Alzheimer’s Disease
- Kosara Smiljanic, Natasa Loncarevic-Vasiljkovic, Selma Kanazir and Aleksandra
- Mladenovic Djordjevic
- Introduction
- Cholesterol in the Brain
- Cholesterol Metabolism in the Brain
- Cholesterol Synthesis
- Cholesterol Transport
- Cholesterol Elimination
- Cholesterol in the Aging Brain
- Cholesterol in Brain Pathologies
- Cholesterol and Alzheimer’s Disease
- The Role of Apolipoprotein E in Alzheimer’s Disease
- The Role of Sreb Proteins in Alzheimer’s Disease
- The Role of Cyp46A1 in Alzheimer’s Disease
- The Role of Cholesterol in Tau Pathology
- Cholesterol and App Processing
- The Role of Cholesterol Esters in Ad Pathogenesis
- The Role of Cholesterol-Lowering Drug Statins in Alzheimer’s Disease
- The Impact of Dietary Restriction on Cholesterol in the Brain
- Concluding Remarks
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 3 Advances in Treatment of Mild Cognitive Impairment (MCI) and Dementia: a Review of Promising Non-Pharmaceutical Modalities
- Zahra Ayati, Dennis Chang and James Lake
- Promising Non-Pharmaceutical Treatments of MCI and Dementia
- Limitations of Conventional Mainstream Treatments
- Non-Pharmaceutical Treatments of Mild Cognitive Impairment
- [Mci] and Dementia
- Lifestyle Changes
- Diet
- Exercise
- Sleep
- Natural Products
- Introduction
- Herbals
- Herbal Medicines Used in Asian Traditional Medicine Systems
- Single Herbs
- Complex Herbal Formulas
- Kami-Untan-To
- Withania Somnifera (Ashwagandha)
- Select Korean, Chinese and Ayurvedic Herbals
- Herbals Used in Other Systems of Medicine
- Non-Herbal Natural Products
- Acetyl-L-Carnitine
- Alpha Lipoic Acid (Ala)
- Combinations of Ala and Other Nutraceuticals
- Folic Acid, B-12, B-6 and Thiamine
- Niacin
- Vitamins C and E
- Dhea and Testosterone
- Estrogen
- Polyunsaturated Fatty Acids [Pufa]
- Phosphatidylserine and Phosphatidic Acid
- Cdp-Choline
- Essential Oils
- Chelating Agents
- Probiotics
- Other Non-Pharmaceutical Treatment Modalities
- Noninvasive Brain Stimulation
- Music Therapy
- Cognitive Training
- Bright Light Exposure
- Eeg-Biofeedback
- Sensory Stimulation Interventions
- Massage Therapy
- Wander Gardens
- Mindfulness
- Multi-Modal Interventions
- Energetic Therapies
- Healing Touch and Therapeutic Touch
- Taichi and Qigong
- Closing Remarks
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 4 Overview of Analytical Methods in Alzheimer’s Disease Drugs: Optical, Chromatographic, and Electrochemical Methods
- Cem Erkmen, Burcin Bozal-Palabiyik and Bengi Uslu
- Introduction
- Analysis of Approved Alzheimer's Disease Drugs
- Chromatographic Techniques for Analyzing Alzheimer's Disease Drugs
- Optical Techniques for Analyzing Alzheimer's Disease Drugs
- Electrochemical Techniques for Analyzing Alzheimer's Disease Drugs
- Analysis of the Main Molecular Targets Under Investigation In
- Alzheimer’s Disease Research
- Conclusion
- Abbreviations
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 5 Targeting Alzheimer’s Disorders Through Nanomedicine
- Mahima Kaushik and Dhriti Jha
- Introduction
- Ad Pathology and Current Treatment Trends
- Factors Influencing the Targeting of Ad
- Targeting Ad Through Nanomedicine
- Drug Delivery Systems and Nanomedicine
- Outlook
- Conflict of Interest
- Consent for Publication
- Acknowledgements
- References
Chapter 6 Current Challenges in Alzheimer’s Disease
- Umar Mushtaq, Amrina Shafi and Firdous A. Khanday
- Introduction
- Pathology
- Symptoms
- Diagnosis
- Therapy
- Recent Signaling Aspect of Ad
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 7 Metals Linked to Alzheimer's Disease
- Hani Nasser Abdelhamid
- Introduction
- Key Proteins in the Brain
- Links Between Metals and Ad
- Biometals Link to Alzheimer's Disease
- Calcium and Magnesium
- Copper
- Iron
- Zinc
- Manganese
- Selenium
- Non-Biological Metals
- Aluminum
- Cadmium
- Other Metals
- Treatments
- Prospective
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
- Subject Index
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Author
- Atta-ur-Rahman
