Handbook of the Biology of Aging, Ninth Edition, provides a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology. The book focuses on the trend of 'big data' approaches in the biological sciences, presenting new strategies to analyze, interpret and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and metabolomics methodologies applied to aging related problems. Sections cover longevity pathways and interventions that modulate aging, innovative tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, and much more.
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Table of Contents
Part I: Basic mechanisms, underlying physiological changes, model organisms and interventions
1. Longevity as a complex genetic trait
2. DNA damage and repair in aging
3. Mechanisms of cell senescence in aging
4. The nature of aging and the geroscience hypothesis
5. Sirtuins, healthspan, and longevity in mammals
6. Integrative genomics of aging
7. Thermogenesis and aging
8. Yeast as a model organism for aging research
9. Model organisms (invertebrates)
10. NIA Interventions Testing Program: A collaborative approach for investigating interventions to promote healthy aging
11. Aging in nonhuman primates
Part II: Organ systems in humans and other animals, human health and longevity
12. Senotherapeutics: Experimental therapy of cellular senescence
13. The role of neurosensory systems in the modulation of aging
14. Aging of the sensory systems: hearing and vision disorders
15. Cardiac aging
16. The aging immune system: Dysregulation, compensatory mechanisms, and prospects for intervention
17. Microbiome changes in aging
18. Lipidomics of aging
19. Trends in morbidity, healthy life expectancy, and the compression of morbidity
