The Science, Etiology and Mechanobiology of Diabetes and Its Complications presents the most comprehensive synthesis of contemporary global research on diabetes, covering a novel and unique mechanobiological perspective - addressing prevention, management and treatment of tissue, organ and body system damage associated with diabetes and its complications. The book provides a unique approach to communicating diabetes-associated symptoms and opens avenues for development of novel therapeutic and preventive methods. It offers descriptive pathophysiology of diabetes and its complications with great emphasis on mechanobiology. Content coverage also includes management of tissue, organ and body system damage caused by chronic hyperglycemia.
Biologists, life scientists, physicians, pharmacists, biomedical engineers, medical physicists, biomathematicians and computer scientists who are interested in the state-of-science and current challenges in the mechanobiology of diabetes should find this book very useful. Likewise, medical researchers in fields such as endocrinology, cardiovascular medicine, oncology, obesity, the immune system, inflammation and wound care and others who wish to be updated about the latest achievements in this exciting arena of research will find that information here.
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Table of Contents
1.�Heel ulcers in patients with diabetes Michael Clark 2.�Diabetic foot ulcers and their wound Management Norihiko Ohura, Katsuya Hisamichi 3.�Computational modeling of the plantar tissue stresses induced by the clinical practice of off-loading of the diabetic foot Hadar Shaulian, Amit Gefen, Alon Wolf 4.�Modeling effects of sustained bodyweight forces on adipose tissue microstructures and adipocytes in diabesity Maayan Lustig, Golan Amrani, Adi Lustig, Liran Azaria, Raz Margi, Yoni Koren, Avraham Kolel, Nurit Bar-Shai, Avior Exsol, Maya Atias, Amit Gefen 5. Mechanisms underlying vascular stiffening in obesity, insulin resistance, and type 2 diabetes Michael A. Hill, Yan Yang, Zhe Sun, Liping Zhang, James R. Sowers 6. Pathomechanics of diabetic foot ulceration: revisiting plantar shear and temperature Metin Yavuz 7. Novel technologies for detection and prevention of diabetic foot ulcers Neil D. Reeves, Bill Cassidy, Caroline A. Abbott, Moi Hoon Yap 8. The role of tissue biomechanics in improving the clinical management of diabetic foot ulcers Panagiotis Chatzistergos, Roozbeh Naemi, Nachiappan Chockalingam 9. The mechanobiology of adipocytes in the context of diabetes: much more than a fat depot Shirley L. Yitzhak-David, Daphne Weihs 10. Optical Coherence Tomography to determine and visualize pathological skin structure changes caused by diabetes Raman Maiti, Roger Lewis, Daniel Parker, Matt J. Carr� 11. Effects of hyperglycemia and mechanical stimulations on differentiation fate of mesenchymal stem cells Tasneem Bouzid, Jung Yul Lim 12. Clinical complications of tendon tissue mechanics due to collagen crosslinking in diabetes Jennifer A. Zellers, Jeremy D. Eekhoff, Simon Y. Tang, Mary K. Hastings, Spencer P. Lake 13. A phenomenological dashpot model for morphoelasticity for the contraction of scars F.j. Vermolen 14. Mechanobiology of diabetes and its complications: from mechanisms to effective mechanotherapies Chenyu Huang, Rei Ogawa 15. Application of tissue mechanics to clinical management of risk in the diabetic foot Daniel Parker, Farina Hashmi 16. Bone carriers in diabetic foot osteomyelitis Cristian Nicoletti 17. Vascular mechanobiology and metabolism Sarah Basehore, Jonathan Garcia, Alisa Morss Clyne 18. Effect of type 2 diabetes on bone cell behavior Rachana Vaidya, Anna Church, Lamya Karim 19. What makes a good device for the diabetic foot Evan Call, Darren F. Groberg, Nick Santamaria 20. Allostasis: a conceptual framework to better understand and prevent diabetic foot ulcers Laurel Tanner, Craig Oberg, Evan Call 21. Footwear for persons with diabetes at high risk for foot ulceration: offloading, effectiveness, and costs Sicco A. Bus 22. Compounding effects of diabetes in vessel formation in microvessel fragmentebased engineered constructs Omar Mourad, Blessing Nkennor, Sara S. Nunes 23. Dressing selection challenges in diabetic foot local treatment Paulo Alves, Tania Manuel, Nuno Mendes, Em�lia Ribeiro, Anabela Moura
Authors
Amit Gefen Professor in Biomedical Engineering, Berman Chair in Vascular Bioengineering, Tel Aviv University, The Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Ramat Aviv, Israel.. Professor Amit Gefen received the B.Sc. in Mechanical Engineering and M.Sc. and Ph.D. in Biomedical Engineering from Tel Aviv University in 1994, 1997, and 2001, respectively. During 2002-2003 he was a post-doctoral fellow at the University of Pennsylvania, USA. He is currently a Full Professor with the Department of Biomedical Engineering at the Faculty of Engineering of Tel Aviv University and the Herbert J. Berman Chair in Vascular Bioengineering. Prof. Gefen has also been the Head of the Ela Kodesz Institute for Medical Engineering and Physical Sciences at Tel Aviv University. The research interests of Prof. Gefen are in studying normal and pathological effects of biomechanical factors on the structure and function of cells, tissues and organs, with emphasis on applications in chronic wound research. He is the Editor-in-Chief of Clinical Biomechanics (published by Elsevier), and has also edited several booksand several Special Issues in journals such as the Annals of Biomedical Engineering, Journal of Biomechanics, Computer Methods in Biomechanics and Biomedical Engineering and more. Recently, Prof. Gefen chaired the Etiology expert panel for development of the International Pressure Ulcer Prevention & Treatment Guidelines (2019) and also chaired the global panel of experts who developed the International Consensus Document for Device-related Pressure Ulcers, published by the Journal of Wound Care (2020).
