Mechanisms and Therapy of Liver Cancer, Volume 149, presents the latest information on the incidence and mortality of liver cancer research and how it has gained significant momentum because of its direct causative association with obesity-induced fatty liver disease. The literature on liver cancer is moving fast with exciting, novel findings, providing new insights reflected in the following updated chapters: Introduction and molecular classification of HCC, Signaling Pathways in Liver Cancer, HCV and HCC, NASH and HCC, Microbiome and Metabolic Abnormalities in HCC, Systemic Therapy of Liver Cancer, Immunotherapy of Liver Cancer, and Desmoplastic Tumor Microenvironment and Intrahepatic Cholangiocarcinoma Progression: Mechanisms and Therapeutic Implications.
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Table of Contents
1. Hepatocellular carcinoma (HCC): Epidemiology, etiology and molecular classificationSaranya Chidambaranathan-Reghupaty, Paul B. Fisher, and Devanand Sarkar
2. Signaling pathways in hepatocellular carcinoma
Teresa Garcia-Lezana, Juan Luis Lopez-Canovas, and Augusto Villanueva
3. Hepatitis C virus associated hepatocellular carcinoma
Mousumi Khatun, Ranjit Ray, and Ratna B. Ray
4. NAFLD-related HCC
Bubu A. Banini and Arun J. Sanyal
5. Atypical immunometabolism and metabolic reprogramming in liver cancer: Deciphering the role of gut microbiome
Rachel M. Golonka and Matam Vijay-Kumar
6. Systemic therapy of liver cancer
Tarik Demir, Sunyoung S. Lee, and Ahmed O. Kaseb
7. Immunotherapy in hepatocellular cancer
Christos Fountzilas, Rachel Evans, Sabah Alaklabi, and Renuka Iyer
8. Intrahepatic cholangiocarcinoma: Morpho-molecular pathology, tumor reactive microenvironment, and malignant progression
Alphonse E. Sirica, Mario Strazzabosco, and Massimiliano Cadamuro
