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Biochemical and Molecular Basis of Pediatric Disease. Edition No. 5

  • Book

  • May 2021
  • Elsevier Science and Technology
  • ID: 5146399

Biochemical and Molecular Basis of Pediatric Disease, Fifth Edition has been a well-respected reference in the field for decades. This revision continues the strong focus on understanding the pathogenesis of pediatric disease, emphasizing not only the important role of the clinical laboratory in defining parameters that change with the disease process, but also the molecular basis of many pediatric diseases.

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Table of Contents

1. Pediatric Clinical Biochemistry: Why Is It Different?
2. Current Approaches to Genetic Testing In Pediatric Disease
3. Data Analytics in Pediatric Laboratory Medicine
4. Disorders in the Neonatal Period
5. Repiratory Disorders in the Neonate
6. Cardiac Disorders
7. Kidney and Urinary Tract Disorders
8. Hepatic and Gastrointestinal Disorders
9. Adrenal Disorders
10. Biochemical and Molecular Evaluation of Thyroid Gland Disorders in Children
11. Disorders of Growth
12. Disorders of Calcium and Phosphate Metabolism in Infants and Children
13. Endocrine Emergencies
14. Biochemical Genetic Disorders
15. Disorders of Iron Metabolism
16. Disorders of Porphyrin Metabolism
17. Erythrocyte Disorders
18. Pediatric Bleeding Disorders
19. Pediatric Thrombotic Disorders
20. Biological and Molecular Markers in the Diagnosis of Childhood Malignancies
21. Primary Immunodeficiency Diseases
22. Allergic Disorders
23. Autoimmune Disorders
24. Cystic Fibrosis
25. Pediatric Therapeutic Drug Monitoring, Toxicology and Pharmacogenomics
26. Adolescent Disorders
27. Pediatric Reproductive Disorders
28. Disorders of Lipid and Lipoprotiein Metabolism
29. Neurological Disorders
30. Psychiatric Disorders

Authors

Edward C.C. Wong Medical Director, Coagulation/Blood Bank, Quest Diagnostics/Nichols Institute, Chantilly, VA, USA. Edward Wong FCAP is Medical Director, Coagulation, Quest Diagnostics Nichols Institute; Adjunct Associate Professor in Pediatrics and Pathology, George Washington School of Medicine and Health Sciences, Clinical Consultant at Children's National Hospital in the Divisions of Pathology and Laboratory Medicine; and Hematology, Washington DC, USA Dennis J. Dietzen Professor of Pathology and Immunology, and Pediatrics, Washington University School of Medicine, Medical Director of Laboratory Services, St. Louis Children's Hospital, MO, USA. Dennis J. Dietzen, PhD, is Professor of Pathology and Pediatrics at Washington University School of Medicine and Medical Director of Laboratories at St. Louis Children's Hospital. He received a B.S. from Marian College in Indianapolis and his Ph.D. from Indiana University. He completed a fellowship in Clinical Chemistry at Washington University in 1995 then served as Development Chemist at the former DuPont Diagnostics and Medical Director of Clinical Laboratories at the Memphis Veterans Affairs Hospital before returning to St. Louis. Dr. Dietzen is a member of the Society for Pediatric Research, the Society for Inborn Metabolic Disorders, and the Academy of Clinical Laboratory Physicians and Scientists. He received the AACC Award for Outstanding Contributions to Pediatric Clinical Chemistry in 2012 and served as AACC President in 2018. Dr. Dietzen serves on the Editorial Board for Clinical Biochemistry and Critical Review in Clinical Laboratory Science and serves as an Associate Editor for the Journal of Applied Laboratory Medicine. Dr. Dietzen's current research interests focus on mass spectrometry applications in pediatrics including drug screening, rapid detection of metabolic disease, liver failure, pre-eclampsia, and neonatal hypoglycemia. He has authored or co-authored more than 100 peer-reviewed publications, monographs, editorials, and book chapters on these and other subjects. Michael J. Bennett Professor Emeritus, Perelman School of Medicine, University of Pennsylvania, PA, USA. Dr. Bennett obtained his PhD in Medical Enzymology from the University of Sheffield School of Medicine (UK) in 1976. He has been actively engaged in Clinical Chemistry since 1975 and has practiced primarily in Children's Hospitals (Sheffield Children's Hospital, Children's Medical Center of Dallas and Children's Hospital of Philadelphia where until his recent retirement he was Chief of Laboratory Medicine) where he developed a clinical and research interest in biochemical genetic diseases. He has published 285 peer-reviewed scientific papers and 53 book chapters, reviews and editorials. He has lectured extensively in the field of pediatric laboratory medicine. He is a Past-President, Treasurer and Board of Directors Member of AACC and Past President of the NACB (now the Academy of AACC) and past-chair of the Pediatric-Maternal Fetal and Metabolomics-Proteomics Divisions of AACC. He has numerous awards for his research and clinical service. He is an Associate Editor for Clinical Chemistry Journal and has sat on the editorial boards of Annals of Clinical Biochemistry, Journal of Inherited Metabolic Diseases and Molecular Genetics and Metabolism. Shannon Haymond Vice Chair for Computational Pathology; Director, Mass Spectrometry, Ann and Robert H. Lurie Children's Hospital of Chicago; Associate Professor of Pathology, Feinberg School of Medicine, Northwestern University, IL, USA. Shannon Haymond is the Vice Chair for Computational Pathology; Director, Mass Spectrometry, Ann and Robert H. Lurie Children's Hospital of Chicago; Associate Professor of Pathology, Feinberg School of Medicine, Northwestern University, IL, USA