Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process.
With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging.
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Table of Contents
1. Theories of stem cell aging 2. Progress in human embryonic stem cell research and aging 3. Stem cell aging and wound healing 4. Stem cells and multiomics approaches in senescence: From benchside to bedside 5. Signaling pathways influencing stem cell self-renewal and differentiation 6. Immunity, stem cells, and aging 7. Aging of hematopoietic stem cells: Insight into mechanisms and consequences 8. Ocular stem cells and again 9. Skeletal muscle cell aging and stem cells 10. Aging and stability of cardiomyocytes 11. Signaling pathways influencing stem cell self-renewal and differentiation Special emphasis on cardiomyocytes 12. Angiogenesis in aging hearts Cardiac stem cell therapy 13. Gut stem cells: Interplay with immune system, microbiota, and aging 14. Cellular senescence and aging in bone 15. Aging-induced stem cell dysfunction: Molecular mechanisms and potential therapeutic avenues 16. Therapeutic approaches for the treatment of aging-induced stem cell dysfunction 17. Role of biological markers in stem cell aging and its implications in therapeutic processes 18. Alternative stromal cell-based therapies for aging and regeneration 19. Stem cell-based therapeutic strategy in delaying prion disease 20. Traditional medicine for aging-related disorders: Implications for drug discovery
