For decades, scientific efforts have been made to understand obesity and related diseases such as type 2 diabetes and neurodegeneration, and their link with meta-inflammation. Adipose tissue is, at present, viewed as an endocrine organ with important biological effects on metabolism and inflammation, with a possible role in the pathogenesis of obesity-associated metabolic and inflammatory diseases. Chronic systemic low-grade inflammation has gained significant attention as the key player in the pathophysiology of obesity- and aging associated diseases. Keeping view of this trend, Meta-Inflammation and Obesity offers readers state-of-the-art knowledge on this subject.
Chapters cover special topics such as gender differences in obesity-related type 2 diabetes as the consequence of inflammatory response, insights into metabolic changes caused by excessive adipose tissue (which lead to abnormal brain metabolism, neuroinflammation, cognitive decline, development of type 3 diabetes), and the importance of inflammaging in the aging process. Graduate, postgraduate and Ph. D. candidates in medicine, pharmacy, and students of applied medicine, health care professionals as well as scientists involved in adipose tissue research, meta-inflammation analysis, obesity-related medical specialties will find this book a useful reference on the link between inflammation and obesity.
Chapters cover special topics such as gender differences in obesity-related type 2 diabetes as the consequence of inflammatory response, insights into metabolic changes caused by excessive adipose tissue (which lead to abnormal brain metabolism, neuroinflammation, cognitive decline, development of type 3 diabetes), and the importance of inflammaging in the aging process. Graduate, postgraduate and Ph. D. candidates in medicine, pharmacy, and students of applied medicine, health care professionals as well as scientists involved in adipose tissue research, meta-inflammation analysis, obesity-related medical specialties will find this book a useful reference on the link between inflammation and obesity.
Table of Contents
Chapter 1 Etiology of Obesity- Introduction
- Body Weight Classification in Adults
- Body Weight Classification in Children
- Weight Gain as a Consequence of Energy Surplus
- Determinants of Obesity
- Biological Determinants
- The Brain-Gut Axis
- The Microbiome
- Viruses
- Neuroendocrine Conditions Causing Secondary Obesity
- Physical and Intellectual Disability
- Prescription Drugs
- Built Environment Risk Factors
- Socio-Cultural Environment Risk Factors
- Behavioral Risk Factors
- Complications and Comorbidities of Overweight and Obesity
- Concluding Remarks
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 2 The Endocrine Function of Adipose Tissue
- Introduction
- Leptin
- Adiponectin
- Resistin
- Visfatin
- Vaspin
- Apelin
- Adipsin
- Omentin
- Adipokines and Inflammation
- Brown Adipose Tissue and Brownkines
- Factor Fibroblast Growth Factor 21 (Fgf21)
- Neuregulin
- Retinol Binding Protein
- Il-6
- Angiopoietin-Like
- Concluding Remarks
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
- Selma Spahić
- Amina Valjevac
Chapter 3 Neuropeptides and Adipokines in the Control of Food Intake
- Introduction
- The Role of Hypothalamus
- Anorexogenic Neurotransmitters
- Orexigenic Neurotransmitters
- Gastrointestinal Hormones
- Pancreatic Hormones
- Adipokines
- Concluding Remarks
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 4 The Role of Meta-Inflammation in the Adipose Tissue
- Dysfunction and Obesity
- Introduction
- Pro-Inflammatory and Anti-Inflammatory Cytokines in Obesity
- The Role of Immune Cells in Adipose Tissue Dysfunction
- The Role of Autophagy in Obesity and Meta-Inflammation
- Concluding Remarks
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 5 Meta-Inflammation, Obesity and Cardiometabolic
- Syndrome
- Introduction
- Obesity-Induced Inflammation
- Dysfunction of Adipose Tissue and Linked Cardiometabolic
- Consequences
- The Phenomenon of Obesity Without Cardiometabolic
- Complications
- Mho - Metabolically Healthy Obese; Bmi - Body Mass Index
- Concluding Remarks
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 6 Gender Differences in Obesity - Related Type 2 Diabetes:
- Possible Role of Meta-Inflammation
- Introduction
- Diabetes Mellitus Type
- Pathogenesis of Obesity-Related Type 2 Diabetes Mellitus And
- Insulin Resistance
- Obesity
- Amina Valjevac
- Asija Začiragić
- Amela Dervišević
- Nermina Babić
- Adipose Tissue
- Meta-Inflammation in Obesity
- Mechanisms of Meta-Inflammation in Obesity
- Gender Differences in Glycemic Control and Food Intake
- Gender Differences in the Etiology and Epidemiology of Obesityrelated
- T2Dm
- Gender Differences in Immunological Response
- Adipose Tissue as a Modulator of Meta-Inflammatory Responses In
- Men and Women
- Sex Hormones as Modulators of Meta-Inflammatory Responses In
- Men and Women
- Concluding Remarks
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 7 Meta-Inflammation, Alzheimer's Disease and Obesity
- Introduction
- Ad as a Diabetes Type
- The Role of Proinflammatory Cytokines in Ad Development
- Inflammasomes and Ad
- Anti-Inflammatory Effects of Antidiabetic Agents in Ad
- Treatment
- Concluding Remarks
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 8 Interplay Between Oxidative Stress and Meta-Inflammation
- In Obesity-Related Neurodegeneration
- Introduction
- Oxidative Stress, Obesity, and Inflammation
- Oxidative Stress, Obesity, and Neurodegeneration
- Concluding Remarks
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 9 Inflammaging and Obesity
- Introduction
- Prevention and Restriction of Inflammaging
- Obesity in the Elderly Individuals
- Linking Inflammaging and Obesity
- Concluding Remarks
- Consent for Publication
- Conflict of Interest
- Almir Fajkić and Lejla Opardija
- Orhan Lepara
- Asija Začiragić
- Acknowledgements
- References
- Subject Index
Author
- Asija Začiragić
