Report Scope:
This report is designed to be a helpful business tool that will provide a thorough evaluation of the markets for pain management. The geographical scope of this study is global. This study will address acute versus chronic pain, treatments, and regulatory issues facing healthcare workers. Also provided is detailed information based on product categories, use of products, forecasts and competitive analyses.
The report identifies two general segments of pain management -
- Pharmaceuticals, including prescription and non-prescription
- Narcotic analgesics
- Non-narcotic analgesics
- Medical cannabis
- Antimigraine agents
- Anesthesia
- CNS therapies
- Other treatments
- Devices
- Electrotherapy
- Spinal cord stimulator
- Other devices
Adjuvant treatment modalities cover a wide range of procedures and methods. Some of the more frequent modalities are discussed throughout the report.
Each market segment provides detailed information based on product categories, product use, and market forecasts.
Not covered in the report are drugs or devices that by treating the condition or disorder result in the relief of pain. These include treatments for rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis or other similar diseases. Treatments are only included for those that indicate a relief of pain symptoms associated with these conditions.
A comparison of treatment for the disease that naturally relieves the symptoms as compared to treatments for the relief of pain associated with the disease include -
- Enbrel: Indicated for the treatment of moderate-to-severe rheumatoid arthritis.
- Celebrex: Indicated for the treatment of the signs and symptoms of osteoarthritis and rheumatoid arthritis and the management of acute pain.
The report is also evaluated in terms of application, discussing market trends and performance for the following areas:
- Surgical pain
- Orthopedic and musculoskeletal pain
- Migraine pain
- Fibromyalgia pain
- Cancer pain
- Neuropathic pain
- HIV/AIDS pain
- Dental pain
- General pain
Report Includes:
- 40 data tables and 43 additional tables
- An overview of the global market for conventional and alternative pain treatments
- Analyses of the global market trends, with data corresponding to market size for 2019, estimates for 2020, and projections of compound annual growth rates (CAGRs) through 2025
- Country-specific data and analysis for the United States, Canada, Brazil, Mexico, Argentina, France, Germany, Italy, UK, Spain, Russia, Australia, China, Japan, and other emerging economies
- Patent study with significant patent allotments on pain treatments, application filings, and new drug approvals
- Identification of companies best-positioned to meet the conventional and alternative pain management markets demand owing to their proprietary technologies, collaborations, M&As and other strategic alliances
- Market share analysis of the leading biopharmaceutical companies and their key competitive landscape
- Global market outlook of pain management services, types of pain, delivery methods, clinical trials, pain incidence/prevalence, reimbursement trends, R&D efforts, and treatment modalities
- A detailed description of the market-leading companies, including Abbott Laboratories, Baxter International, Eli Lilly & Co., GlaxoSmithKline, and Johnson & Johnson
Table of Contents
Chapter 1 Introduction
- Study Goals and Objectives
- Reasons for Doing This Study
- Scope of Report
- Information Sources
- Methodology
- Geographic Breakdown
- Analyst's Credentials
- Custom Research
- Related Reports
Chapter 2 Summary and Highlights
- Overview
- Summary of the Major Markets
- Competitive Structure and Market Share
- Market Trends
- Undertreatment Issues
- Professional Pain Treatment Issues
- Access to Care
- FDA Requirements for Approval of Pain Therapies
- Drug Delivery Systems
Chapter 3 Industry Overview
- Pain Management Market Opportunity
- Total Pain Treatment Market
- History of Pain and Pain Treatment
- The Perception of Pain
- Types of Pain
- Acute Pain
- Chronic Pain
- Physiological Pain Classifications
- Assessment of Pain
- Subjective
- Objective
- Diagnosis of Pain
- How Pain is Treated
- Opioid Pain Control
- The Opioid Crisis: Addiction and Abuse
- FDA Response to the Opioid Crisis-Risk Evaluation and Mitigation Strategy (REMS)
- Opioid Treatment Challenges
- Drug Delivery Systems
- Oral and Extended Release
- Topical and Transdermal
- Intravenous
- Intranasal
- Patient-Controlled Analgesia
- Iontophoresis
- Electromechanical Transport
- Pain Management Procedures: Steroids, Endoscopy, Fluoroscopy
- Alternative Methods of Pain Management
- Growing Trend in Cannabis Treatment for Pain
- Adoption of Medical Cannabis: A Global Analysis
- Laws and Legalization Trends
- Claims in Effectiveness
- Potency and Validation Testing Trends
- Pain Management Services and Organizations
- Home Care
- Hospice
- Hospitals
- Pain Clinics
- Skilled Nursing Facilities
- Access to Palliative Care Around the World
- Assessing the Need for Palliative Care
- Market Influences and Indicators of Growth
- Global Demographic Overview
- Gender and Pain
- Other Influences Determining How Pain is Felt among Individuals
- Undertreatment Issues
- Treatment of Pain and Issues Facing the Professional Segment
- Prescription Drug Monitoring Programs
- Availability of Medication
- Government Intervention
- Managed Care Pain Management Issues
Chapter 4 Pain Treatment Markets by Type
- Overview
- Market Summary
- Pharmaceutical Pain Management
- Pain Management Products
- Acetaminophen and FDA Changes
- Codeine in Cough and Cold Medications
- Total Market
- FDA Approval of Pain Therapies
- Pharmaceutical Pipeline
- Narcotic Analgesics
- Non-narcotic Analgesics
- Medical Cannabis
- Antimigraine Agents
- Anesthetics
- Other CNS Therapies
- Other Treatments
- Pain Management Devices
- FDA Approval of Pain Devices
- Pain Management Device Market
- Total Market
- Stimulation Therapy
- Physical Pain Treatment Modalities
- Acupuncture/Acupressure
- Ice (Cryotherapy)
- Joint Mobilization
- Manipulation
- Massage
- Traction
- Radiation Therapy
- Radio Frequency Neuroablation, Epiduroscopy
- Surgery
- Whirlpool Bath (Thermotherapy)
- Psychological Pain Therapies
- Tracking the Development of Complementary and Alternative Pain Control Methods
Chapter 5 Market Breakdown by Application
- Overview
- Market Size and Growth
- Surgical Pain Management
- Orthopedic/Musculoskeletal Pain Management
- Migraine Headache Pain Management
- Fibromyalgia Pain
- Cancer Pain Management
- Neuropathic Pain
- HIV/AIDS Related Pain
- Burn Pain
- Dental Pain
Chapter 6 Market Breakdown by Region
- Overview
- Market Size and Growth
- Global Health Indicators
- Health Expenditures and GDP Review
- Average Length of Stay
- Markets by Global Region
- North America
- Canada
- United States
- Europe, Middle East, Africa (EMEA)
- France
- Germany
- Italy
- Russia
- Spain
- United Kingdom
- Asia-Pacific
- Australia
- China
- Japan
- Latin America
- Argentina
- Brazil
- Mexico
Chapter 7 Patent Analysis and New Developments
- Patent Analysis
- Patent Review by Year
- Patent Review by Type
- Patent Review by Company
- Patent Review by Country
- Patent Review by Assignee
- Impact of Generic Participation
- Future of Pain Research
- Selected Pain-Related Acquisitions, Alliances and Events
Chapter 8 Company Profiles
- Abbott Laboratories
- Abbvie Inc.
- Amgen Inc.
- Aphria Inc.
- Assertio Therapeutics
- Aurora Cannabis Inc.
- Baxter International
- Bedrocan International
- Boehringer Ingelheim International Gmbh
- Boston Scientific Corp.
- Collegium Pharmaceuticals Inc.
- Canopy Growth Corp.
- Cronos Group Inc.
- Dr. Reddy's Laboratories Ltd.
- Eli Lilly & Co.
- Endo International Plc
- Fresenius Kabi Ag
- Glaxosmithkline
- Grunenthal Gmbh
- Gw Pharmaceuticals
- Hisamitsu Pharmaceutical Co. Inc.
- Horizon Therapeutics Plc
- Johnson & Johnson
- Medical Marijuana Inc.
- Medropharm Gmbh
- Medtronic Plc
- Merck & Co. Ltd.
- Novartis Ag
- Pfizer Inc.
- Purdue Pharma Lp
- Teva Pharmaceutical Industries Ltd.
Chapter 9 Appendix: Terminology and Sources of Information
- Pain Management Pharmaceutical Manufacturers and Developers
- U.S. Pain Societies and Associations
- International Associations and Organizations
List of Tables
Summary Table: Global Market for Conventional and Alternative Pain Treatments, by Major Segment, Through 2025
Table 1: Market Opportunities and Highlights for Pain Treatments, 2020-2025
Table 2: Physiological Effects of Pain
Table 3: Objective Signs of Pain
Table 4: United States Opioid Addiction and Abuse Statistics
Table 5: Global Opioid Addiction and Abuse Statistics
Table 6: List of Brand Name Extended-Release and Long-Acting Opioid Products Required to be Included in Opioid REMS
Table 7: List of Generic Extended-Release and Long-Acting Opioid Products Required to be Included in Opioid REMS
Table 8: List of Transmucosal Immediate-Release Fentanyl Products Required to be Included in the TIRF REMS Access Program
Table 9: List of Other Pain-Related REMS-Required Products
Table 10: List of Products Subject to the TIRF REMS Access Program
Table 11: Advantages of Iontophoretic Drug Delivery
Table 12: Adoption of Medical Cannabis in Population Aged 15 Years and Above, by Select Country, 2020
Table 13: U.S. Medical Marijuana/Cannabis Programs, by State
Table 14: European Medical Marijuana/Cannabis Regulation, by Country
Table 15: Select Country Medical Marijuana/Cannabis Regulation
Table 16: Effectiveness of Fibromyalgia Treatments: Cannabis vs. Pharmaceutical Therapies, 2014
Table 17: Shares of the U.S. Hospice Patients, by Gender and Age Group, 2010-2018
Table 18: Hospice Admissions Shares, by Primary Diagnosis, 2016-2018
Table 19: NHPCO Committees
Table 20: Definition of Pain Clinics
Table 21: Desirable Characteristics of Pain Clinics, by Type
Table 22: Registered Pain Clinics, by Country
Table 23: Global Population Growth, by Select Country, Through 2030
Table 24: Global Population Growth, by Age Group, Through 2050
Table 25: Global Population Growth, Aged 65+ Years and Above, by Select Country, Through 2030
Table 26: Global Life Expectancy at Birth, by Select Country, 2020 Estimate
Table 27: Pain in the Age 18+ U.S. Population*, by Select Gender, 1997-2010
Table 28: Agency Responsible for PDMP in Each State
Table 29: Benefits of Prescription Monitoring Programs for Medical Boards
Table 30: Drugs Monitored by PDMPs, by State
Table 31: WHO List of Essential Medicines for Adult Pain Management
Table 32: Availability of Injectable Morphine, by Region
Table 33: Availability of Oral Morphine in Hospice-Type Settings, by Region
Table 34: FDA Reported Pain and Anesthesia Drug Shortages, by Status and Drug, January 2020-September 2020
Table 35: Global Market for Pain Management, by Major Type, Through 2025
Table 36: Share of Pharmaceutical Pain Management Treatment Markets, by General Classification, 2020
Table 37: FDA Applications/Approvals, January 2010-August 2020
Table 38: List of Prescription Cough and Cold Medicines Containing Codeine
Table 39: List of Prescription Cough and Cold Medicines Containing Hydrocodone
Table 40: Global Market for Pain Management Pharmaceuticals, by Product Category, Through 2025
Table 41: Select Pain Management Drugs in Pipelines, by Company
Table 42: Pediatric Pain Management Indications Select Pipeline, by Company
Table 43: Selected Approved ER/LA Opioids with Abuse Deterrent Properties
Table 44: List of NSAIDs
Table 45: Selected Cannabis Clinical Trials for Pain Treatment, as of September 15, 2020
Table 46: Most Commonly Used General Anesthetic Agents
Table 47: Global Market for Allergan’s Botox, by Treatment Area, 2020 (based on 6M Sales)
Table 48: Parts 862-892 of 21 CFR
Table 49: Global Market for Pain Management Devices, by Technology Type, Through 2025
Table 50: Use of Complementary and Alternative Medicine among U.S. Adults, by Type of Therapy, 2002-2018
Table 51: Global Market for Pain Management, by Application, Through 2025
Table 52: Global Market for Surgical Pain Management, by Product Type, Through 2025
Table 53: Annual No. of Operations, by Country (Estimated)
Table 54: Birth Rates and Births, by Select Country, 2020 and 2025
Table 55: Global Market for Orthopedic/Musculoskeletal Pain Management, by Product Type, Through 2025
Table 56: Global Market for Migraine/Headache Pain Management, by Product Type, Through 2025
Table 57: Global Market for Fibromyalgia Pain Management, by Product Type, Through 2025
Table 58: Cancer Pain Medication
Table 59: Global Market for Cancer Pain Management, by Product Type, Through 2025
Table 60: Global Market for Neuropathic Pain Management, by Product Type, Through 2025
Table 61: Global Market for HIV/AIDS Pain Management, by Product Type, Through 2025
Table 62: Global Market for Burn Pain Management, by Product Type, Through 2025
Table 63: Global Market for Dental Pain Management, Through 2025
Table 64: Global Market for Pain Management, by Region, Through 2025
Table 65: Health Expenditures as a Percentage of GDP, by Select Country, 1980-2019
Table 66: Average Hospital Length of Stay, by Select Country, 1970-2019
Table 67: Major Countries, by Region
Table 68: North American Market for Pain Management, by Type, Through 2025
Table 69: North American Market for Pain Treatment, by Country, Through 2025
Table 70: EMEA Market for Pain Management, by Type, Through 2025
Table 71: EMEA Market for Pain Treatment, by Country, Through 2025
Table 72: Asia-Pacific Market for Pain Management, by Type, Through 2025
Table 73: Asia-Pacific Market for Pain Treatment, by Country, Through 2025
Table 74: Latin American Market for Pain Management, by Type, Through 2025
Table 75: Latin American Market for Pain Treatment, by Country, Through 2025
Table 76: U.S. Patents Issued on Pain Treatments, by Year, January 2000-August 2020
Table 77: U.S. Patents Issued on Pain Technologies, by Abstract Description, January 2000-August 2020
Table 78: Recent Country Patents on Pain Technologies, August 18, 2020-September 22, 2020
Table 79: First Time Prescription Generic Pain Management and Approvals, January 2010-August 2020
Table 80: Glossary of terms used in Pain Management Drug and Device Markets
Table 81: Pain Management Therapy Manufacturers and Developers
Table 82: U.S. Pain Societies and Associations
Table 83: International Associations and Organizations
List of Figures
Summary Figure: Global Market for Conventional and Alternative Pain Treatments, by Major Segment, 2019-2025
Figure 1: Global Market for Conventional and Alternative Pain Treatments, 2019-2025
Figure 2: Pain Management Techniques
Figure 3: Annual Number of U.S. Hospice Patients, 2010-2018
Figure 4: U.S. Shares of Hospice Patients, by Gender, 2010-2018
Figure 5: U.S. Shares of Hospice Patients, by Age Group, 2010-2018
Figure 6: Distribution of Causes of Mortality and Potential need for Palliative Care, 2017*
Figure 7: Global Population Growth, by Select Country, 2019 and 2030
Figure 8: Global Population Growth, by Age Group, 2000-2050
Figure 9: Global Population Growth, Aged 65+ Years and Above, by Select Country, 2019 and 2030
Figure 10: Global Life Expectancy at Birth, by Select Country, 2020 Estimate
Figure 11: Pain in the Age 18+ U.S. Population*, by Select Gender, 1997-2010
Figure 12: Distribution of Narcotic Drug Consumption, by Country (All Narcotic Types), 2015
Figure 13: Distribution of Morphine Consumption, by Region/Country, 2015
Figure 14: Obstacles to Availability of Opioids for Medical Needs
Figure 15: Global Market for Pain Management, by Major Type, 2019-2025
Figure 16: Global Market for Pain Management Pharmaceuticals, by Product Category, 2019-2025
Figure 17: Shares of Pain Management Drugs in Pipeline, by Development Status
Figure 18: Shares of Pain Management Drugs in Pipeline, by Primary Indication
Figure 19: Global Market Shares of Narcotic Pain Treatments, by Indication, 2020
Figure 20: Global Market Shares of Narcotic Analgesics, by Ingredient*, 2020
Figure 21: Market Shares Distribution: Non-Narcotic Analgesics, Rx vs. OTC, 2020
Figure 22: Global Market Shares of Non-Narcotic Pain Treatments, by Indication, 2020
Figure 23: Global Market Shares of Non-Narcotic Analgesics, by Ingredient*, 2020
Figure 24: Global Market Shares of Medical Cannabis: Pain vs. All Other Uses, 2020
Figure 25: Global Market Shares of Medical Cannabis Pain Treatments, by Indication, 2020
Figure 26: Global Market Shares of Antimigraine Agents, by Classification, 2020
Figure 27: Global Market Shares of Antimigraine Agents, by Ingredient*, 2020
Figure 28: Global Market Shares of Anesthetics, by Ingredient*, 2020
Figure 29: Global Market Shares of CNS Pain Treatments, by Indication, 2020
Figure 30: Global Market Shares of Capsaicin-Derived Pain Treatments, by Indication, 2020
Figure 31: Global Market Shares of Menthol-Containing Pain Treatments, by Indication, 2020
Figure 32: Global Market Shares of Omega-3 Fatty Acid-Containing Pain Treatments, by Indication, 2020
Figure 33: Global Market Shares of Botulinum Toxin Pain Treatments, by Indication, 2020
Figure 34: Global Market for Pain Management Devices, by Technology Type, 2019-2025
Figure 35: Use of Complementary and Alternative Medicine among U.S. Adults, by Type of Therapy, 2002-2018
Figure 36: Global Market for Pain Management, by Application, 2019-2025
Figure 37: Global Market for Surgical Pain Management, by Product Type, 2019-2025
Figure 38: Birth Rates and Births, by Select Country, 2020 and 2025
Figure 39: Arthritis Impact, Global Prevalence, by Year, 2000-2050
Figure 40: Global Cancer Mortality, by Select Country, 1960-2020 (Estimated)
Figure 41: Causes of Cancer Pain
Figure 42: Burn Pain Management Approach
Figure 43: Global Market for Pain Management, by Region, 2019-2025
Figure 44: Health Expenditures as a Percentage of GDP, by Select Country, 1980-2019
Figure 45: North American Market for Pain Treatment, by Country, 2019-2025
Figure 46: North American Market Shares of Pain Treatment, by Country, 2020
Figure 47: Canadian Market Shares of Pain Treatments, by Product Segment, 2020
Figure 48: Canadian Market Shares of Pain Treatments, by Application, 2020
Figure 49: U.S. Market Shares of Pain Treatments, by Product Segment, 2020
Figure 50: U.S. Market Shares of Pain Treatments, by Application, 2020
Figure 51: EMEA Market for Non-opioid Pain Treatment, by Country, 2019-2025
Figure 52: EMEA Market Shares of Pain Treatments, by Country, 2020
Figure 53: French Market Shares of Pain Treatments, by Product Segment, 2020
Figure 54: French Market Shares of Pain Treatments, by Application, 2020
Figure 55: German Market Shares of Pain Treatments, by Product Segment, 2020
Figure 56: German Market Shares of Pain Treatments, by Application, 2020
Figure 57: Italian Market Shares of Pain Treatments, by Product Segment, 2020
Figure 58: Italian Market Shares of Pain Treatments, by Application, 2020
Figure 59: Russian Market Shares of Pain Treatments, by Product Segment, 2020
Figure 60: Russian Market Shares of Pain Treatments, by Application, 2020
Figure 61: Spanish Market Shares of Pain Treatments, by Product Segment, 2020
Figure 62: Spanish Market Shares of Pain Treatments, by Application, 2020
Figure 63: U.K. Market Shares of Pain Treatments, by Product Segment, 2020
Figure 64: U.K. Market Shares of Pain Treatments, by Application, 2020
Figure 65: Asia-Pacific Market for Pain Treatment, by Country, 2019-2025
Figure 66: Asia-Pacific Market Shares of Pain Treatments, by Country, 2020
Figure 67: Australian Market Shares of Pain Treatments, by Product Segment, 2020
Figure 68: Australian Market Shares of Pain Treatments, by Application, 2020
Figure 69: Chinese Market Shares of Pain Treatments, by Product Segment, 2020
Figure 70: Chinese Market Shares of Pain Treatments, by Application, 2020
Figure 71: Japanese Market Shares of Pain Treatments, by Product Segment, 2020
Figure 72: Japanese Market Shares of Pain Treatments, by Application, 2020
Figure 73: Latin American Market for Pain Treatment, by Country, 2019-2025
Figure 74: Latin American Market Shares of Pain Treatment, by Country, 2020
Figure 75: Argentinean Market Shares of Pain Treatment, by Product Segment, 2020
Figure 76: Argentinean Market Shares of Pain Treatment, by Application, 2020
Figure 77: Brazilian Market Shares of Pain Treatment, by Product Segment, 2020
Figure 78: Brazilian Market Shares of Pain Treatment, by Application, 2020
Figure 79: Mexican Market Shares of Pain Treatment, by Product Segment, 2020
Figure 80: Mexican Market Shares of Pain Treatment, by Application, 2020
Figure 81: U.S. Shares of Patents Issued on Pain Technologies, by Year, January 2000-August 2020
Figure 82: U.S. Shares of Patents Issued on Pain Technologies, by Abstract Description
Figure 83: Country Patent Shares of Pain Technologies
Figure 84: FDA Generic Pain Drug Approvals, by Year, 2010-2020
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Executive Summary
The pain management market is a diverse market offering both products and services to alleviate pain. Manufacturers have attempted to create well-rounded and advanced products to give clinicians a wider range of choices for pain management. As the population ages and regulatory and cost issues reduce hospital stays and increase home care and other forms of long-term care, awareness of the real costs associated with pain management is growing.
Prescription pharmaceuticals include a number of market-leading pain management products, while non-prescription therapies, accounting for over half of all sales, including the growing market for medical cannabis in pain control. For the purpose of this study, medical cannabis is reported as non-prescription, due to the variance in regulation throughout the world; although in some countries it is required to have a prescription or medical clearance card, these therapies are not regulated in the traditional sense by approval authorities such as the FDA. The device segment offers a different approach to pain treatment, focusing on electrotherapy and similar technologies to achieve pain control or management.
As demonstrated in the report, the pain management drug category will continue to generate the majority of sales (>94%) throughout the forecast period. Recent advances in technology, however, are helping drive growth in the pain management device markets.
Companies Mentioned
- Abbott Laboratories
- Abbvie Inc.
- Amgen Inc.
- Aphria Inc.
- Assertio Therapeutics
- Aurora Cannabis Inc.
- Baxter International
- Bedrocan International
- Boehringer Ingelheim International Gmbh
- Boston Scientific Corp.
- Canopy Growth Corp.
- Collegium Pharmaceuticals Inc.
- Cronos Group Inc.
- Dr. Reddy's Laboratories Ltd.
- Eli Lilly & Co.
- Endo International Plc
- Fresenius Kabi Ag
- Glaxosmithkline
- Grunenthal Gmbh
- Gw Pharmaceuticals
- Hisamitsu Pharmaceutical Co. Inc.
- Horizon Therapeutics Plc
- Johnson & Johnson
- Medical Marijuana Inc.
- Medropharm Gmbh
- Medtronic Plc
- Merck & Co. Ltd.
- Novartis Ag
- Pfizer Inc.
- Purdue Pharma Lp
- Teva Pharmaceutical Industries Ltd.
