The field of oral microbiology has seen fundamental conceptual changes in recent years. Microbial communities are now seen as the fundamental etiological agent in oral diseases through their interface with host inflammatory responses. Study of structured microbial communities has increased our understanding of the roles of each member in the pathogenesis of oral diseases, principles that apply to both periodontitis and dental caries.
Against this backdrop, the third edition of Oral Microbiology and Immunology has been substantially expanded and rewritten by an international team of authors and editors. Featured in the current edition are:
- links between oral infections and systemic disease
- revised and updated overview of the role of the immune system in oral infections
- thorough discussions of biofilm development and control
- more extensive illustrations and Key Points for student understanding
Graduate students, researchers, and clinicians as well as students will find this new edition valuable in study and practice. The field of oral microbiology has seen fundamental conceptual changes in recent years. Microbial communities are now seen as the fundamental etiological agent in oral diseases through their interface with host inflammatory responses. Study of structured microbial communities has increased our understanding of the roles of each member in the pathogenesis of oral diseases, principles that apply to both periodontitis and dental caries.
Table of Contents
Contributors xxi
Preface xxv
About the Editors xxvii
Section I General Principles of Oral Microbiology and Immunology 1
1 General Microbiology 3
Howard F. Jenkinson
Key points 28
2 The Immune System and Its Functions 29
George Hajishengallis and Jonathan M. Korostoff
Key points 50
Further Reading 51
3 The Oral Environment 53
Frank A. Scannapieco and Stefan Ruhl
Key points 80
Further Reading 80
4 Isolation, Classification, and Identification of Oral Bacteria 81
Eugene J. Leys, Ann L. Griffen, and Clifford Beall
Key points 99
Further Reading 99
5 Oral Microbial Ecology 101
Howard F. Jenkinson and Richard J. Lamont
Key points 121
Further Reading 122
6 Oral Microbial Physiology 123
Paul G. Egland and Robert E. Marquis
Key points 147
Further Reading 147
7 Genetics and Molecular Biology of Oral Microorganisms 149
Angela H. Nobbs, Bing-Yan Wang, and Gena D. Tribble
Key points 187
Further Reading 188
8 Applied Molecular Biology and the Oral Microbes 189
Hansel M. Fletcher, Arunima Mishra, Sasanka Chukkapalli, Stuart Dashper, and Ann Progulske-Fox
Key points 211
Further Reading 212
9 Population Genetics of Oral Bacteria 213
Mogens Kilian
Key points 225
Further Reading 226
10 Immunology of the Oral Cavity 227
Evlambia Hajishengallis and George Hajishengallis
Key points 248
Further Reading 248
Section II Infection-Driven Oral Diseases 249
11 Dental Caries: Etiology and Pathogenesis 251
William H. Bowen, Livia M. A. Tenuta, Hyun Koo, and Jaime A. Cury
Key points 265
Further Reading 265
12 Pathogenic Mechanisms in Dental Caries 267
José A. Lemos, Hui Wu, Robert G. Quivey, Jr., and Hyun Koo
Key points 284
Further Reading 285
13 Periodontal Diseases: General Concepts 287
Panos N. Papapanou
Key points 307
Further Reading 307
14 Virulence Factors of Periodontal Bacteria 309
Richard J. Lamont, Janina P. Lewis, and Jan Potempa
15 Immunopathogenic Mechanisms in Periodontal Disease 333
George Hajishengallis
Key points 356
Further Reading 357
16 Oral Virology 359
Matti Sällberg
Key points 395
Further Reading 396
17. Fungi and Fungal Infections of the Oral Cavity 397
Richard D. Cannon, Ann R. Holmes, and Norman A. Firth
Key points 414
Further Reading 415
18 Endodontic Infections and Therapeutic Approaches 417
Brenda P. F. A. Gomes, Isabela N. Rôças, and José F. Siqueira, Jr.
Further Reading 432
19 Systemic Disease and the Oral Microbiota 433
Angela H. Nobbs and Mark C. Herzberg
Section III Control of Oral Diseases 455
20 Antibiotics: Mechanisms of Action, Resistance, and Clinical Use in Dentistry 457
Pin-Chuang Lai, Hyun Koo, Paul Stoodley, and John Walters
Key points 494
Further Reading 494
21 Therapeutic Approaches for Biofilm Control and Host Modulation in Oral Diseases 495
Yijin Ren, Henry C. van der Mei, George Hajishengallis, Hyun Koo, and Henk J. Busscher
Key points 522
Further Reading 522
22 Infection Prevention and Control in Dentistry 525
J. Christopher Fenno, Stephen J. Stefanac, and Brandonn K. Perry
Key points 549
Further Reading 550
Index 551
