Conceptual Breakthroughs in The Evolutionary Biology of Aging

Table of Contents

1. Natural Selection is the Ultimate Determinant of Aging
2. Basic Mathematics of Selection with Age-Structure and Matching Lab Data
3. First Explanation of Aging by Age-Specific Patterns of Selection
4. First Proposal of the General Idea of Declining Force of Natural Selection
5. Hypotheses for the Evolutionary Genetics of Aging
6. Absence of a Lansing effect in Inbred Drosophila
7. Presence of Aging in a Fish with Continued Adult Growth
8. Mathematical Derivation of the Forces of Natural Selection
9. Falsification of the Somatic Mutation Theory
10. Falsification of the Translation Error Catastrophe Theory
11. Proposal of Experimental Designs to Test Evolutionary Theories of Aging
12. Accidental Evolutionary Postponement of Aging
13. Experimental Evolution of Accelerated Aging in Tribolium
14. Development of Evolutionary Genetics in Age-Structured Populations
15. Application of Charlesworth's Theory to the Evolution of Aging
16. Full Development of Evolutionary Genetic Theory for Aging
17. Quantitative Genetics tests of Hypotheses for the Evolution of Aging
18. Reproducible Mitigation of Aging by Postponing the Decline in Forces of Natural Selection
19. Discovery and Characterization of Caenorhabditis elegans Mutants with Extended Lifespan
20. Further Mathematical Characterization of Evolution with Antagonistic Pleiotropy
21. Genetic Covariation is Shifted to Positive Values by Inbreeding
22. Additional Experiments Supporting Antagonistic Pleiotropy
23. Direct Demonstration of Non-Aging in Fissile Species
24. Genotype-by-Environment Interaction Shown for Aging
25. Evolutionary Physiology of Aging
26. Accelerated Senescence Explained in terms of Inbreeding Depression
27. Reverse Evolution of Aging
28. Genetic Analysis of Aging in Males
29. Quantitative Genetic Analysis of How Many Genes Determine Aging
30. Evidence for Senescence in the Wild
31. Molecular Genetic Variation at Selected Loci in the Evolution of Aging
32. The Evolutionary Logic of Extending Lifespan by Dietary Restriction
33. Selection for Stress Resistance Increases Lifespan
34. In Late Adult Life, Mortality Rates Stop Increasing
35. Evolution of Increased Longevity Among Mammals in the Wild and the Lab
36. Evolutionary Physiology of Dietary Restriction
37. Genetic Association between Dauer Metabolic Arrest and Increased Lifespan
38. Experimental Evolution of Aging is Connected to Development
39. Evidence for Mutation Accumulation affecting Virility Aging
40. Deep Physiological Research into the Evolution of Aging Supports Organismal Mechanisms
41. Late-life Mortality Plateaus Explained using Evolutionary Theory
42. Falsification of Lifelong Heterogeneity Models for the Cessation of Aging
43. Discovery of Drosophila Mutants Sometimes Increasing Longevity
44. Nematode Longevity Mutants show Antagonistic Pleiotropy
45. Experimental Evolution of Life-History fits the Evolutionary Analysis of Late Life
46. Breakdown in Correlations between Stress Resistance and Aging
47. Alternative Indicators for the Forces of Natural Selection Proposed
48. Development of Demographic Models that Separate Aging from Dying
49. Genome-wide Sequencing of Experimentally Evolved Aging Reveals Many Genetic Sites
50. Studying the Evolutionary Origins of Aging in Bacteria
51. Evolutionary Transcriptomics also reveal Complex Physiology of Aging
52. Late Life is Physiologically Different from Aging
53. Genomic Studies of Centenarians Having Low Scientific Power
54. Evolutionary Genetic Effects Produce Two Evolutionary Biologies of Aging
55. Experimental Evolution can Produce Non-Aging Young Adults
56. The Heart is Implicated in the Evolution of Aging
57. Machine Learning Unpacks the Genomics of the Evolution of Aging

Authors

Kenneth R. Arnold Graduate Researcher, University of California at Irvine, USA. Kenneth R. Arnold is a Graduate Researcher at the University of California at Irvine, working with Dr. Michael Rose in the Department of Ecology and Evolutionary Biology. He is also the Laboratory Stock Manager in the Laboratory of Dr. Michael Rose and Dr. Laurence Mueller at UCI. His studies and area of expertise deal with evolutionary biology and genomic trajectories Michael R. Rose Professor of Ecology and Evolutionary Biology, University of California at Irvine, USA. Michael Rose is a Distinguished Professor of Ecology and Evolutionary Biology at the University of California at Irvine. Since 2006, he also serves as the Director of the Network for Experimental Research on Evolution. Dr. Rose is widely recognized as a leading researcher in evolutionary biology, specifically the effects of this on aging humans; he published a groundbreaking book on this subject in 1991. In addition to this book publication, Dr. Rose has written hundreds of academic journal papers on evolution, evolutionary biology, and the evolution of aging.