The intestine is among the leading organs, in which several cutting edge in vitro and in vivo research tools and approaches have recently been developed and used to investigate stem cell biology/function, and the potential applications of stem cells in the treatment of intestinal diseases. These cutting-edge research tools and approaches involve human and murine organoid cultures, genetic editing in vitro and in vivo, human induced pluripotent cell (iPS cell) models of disease, haploid cells for genetic as well as compound screening paradigms, genetically engineered mice, and stem cell transplantation to cure diseases.
Stem Cell Innovation in Health and Disease: Volume 1: The Intestine contains two major sections describing cutting edge research for understanding stem cell functions in the intestine, and for developing methods to bring stem cells from bench to bedside; respectively. Each section includes insights ranging from using mouse and human organoid cultures, genetic editing in vitro and in vivo, and human induced pluripotent cells (iPSCs) to study stem cell functions and model intestinal diseases, through the cutting-edge research, including the potential application of iPSCs, ESCs and blood stem cells (stem cell transplants) in the treatment of intestinal diseases/disorders. This volume, therefore, discusses the fact-based promise of stem cells and regenerative medicine in the intestine in the real world.
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Table of Contents
Section 1: Cutting edge research on the intestinal stem cell functions 1. Intestinal organoid cell culture as a new modality to intestinal function, cellular processes and stem cell functions 2. Intestinal organoids in gastrointestinal pathology
Section 2: Cutting edge research on stem cell application in the intestinal diseases (from bench to bed) 3. Intestinal organoid culture as a new test-bed for intestinal therapeutic research and development 4. Engineered stem cells combine stem cell and gene therapy approaches to move intestine therapy from bench to bed 5. Application of CRISPR/Cas9 and other gene editing/ engineering technology in intestine diseases 6. New approaches for intestine and colon repair via stem cell-based tissue engineering 7. iPSCs and intestine diseases from bench to bed 8. The potential of embryonic stem cells for treating intestinal diseases from bench to bed 9. Stem-cell therapy with bone marrow (hematopoietic) stem cells for intestinal diseases 10. Mesenchymal and other stem cell-therapy of intestinal diseases
