The Regeneration Promise is a reader-friendly guide to the world of regenerative medicine and stem cell technology. It covers the history of stem cell technology as a general introduction to the subject and then continues with a description of the many known types of stem cell and how these can potentially be used to treat disease. The author explains the pros and cons of using stem cell technology to treat patients in simple and factual terms throughout the book while clarifying many stem cell myths.
There is valuable advice for people considering undergoing stem cell therapy and also for those who are considering stem cell storage such as umbilical cord blood storage at the birth of a baby. The book also covers information on current research in stem cell technology and how this may be useful in the clinic, as promising regenerative medicine treatments emerge in the near future. The simple use of language with a clear explanation of scientific terms, where applicable, make this book an accessible source of information for anyone interested in enhancing their general knowledge about regenerative medicine when considering such treatment options and understanding the debate surrounding stem cell technology and its use in disease therapy.
Table of Contents
Chapter 1 a Bit of History
- Interesting Times
- Stem Cells are Everywhere!
- Bone Marrow Stem Cells
- Back Again to 1956
- Tissue Typing or ‘Tissue Matching’
- From Embryos to Stem Cells
- From Mouse to Man?
- More Mouse Embryos!
- Stem Cells in the Blood
- Cord Blood Stem Cells
- Cord Blood Transfusion
- Human Embryonic Stem Cells
- Adult or Fetal Stem Cells?
- Umbilical Cord Tissue and Placenta Tissue Stem Cells
- Fat Stem Cells!
- The Tooth Fairy and Stem Cells
- ‘Man-Made’ Stem Cells
- Initial Conclusions
- Key Points of Chapter 1
Chapter 2 Blood and Toil
- ‘Blood Forming’ Stem Cells
- Bone Marrow Transplantation
- Haploidentical Transplantation
- Find the Match
- Bone Marrow Stem Cell Banks
- Preparation for Transplant
- Transplant Time
- Recovery
- It's Not Easy!
- ‘Tissue Forming’ Stem Cells in Bone Marrow
- Clinical Trials
- Four Phases
- Bone Marrow Stem Cells and Heart Attack
- Bone Marrow Stem Cells and Autoimmune Disease
- The Right Stem Cell and a Holistic Approach
- Bone Marrow Stem Cells and Osteoarthritis
- Clinical Trials
- Bone Marrow and Other Diseases
- Key Points of Chapter 2
Chapter 3 A Bouncing Baby!
- Cord Blood Stem Cells
- Cord Blood Stem Cell Collection Process
- Cord Blood Stem Cell Storage Options
- Cord Blood Laboratory Processing
- Cord Blood Stem Cells Pros and Cons
- Cord Blood Stem Cell Double Transplants and Expansion
- Quality Not Quantity
- Cord Blood Stem Cell Clinical Trial for Cerebral Palsy
- Cord Blood Stem Cell Clinical Trial for Autism
- Key Points of Chapter 3
Chapter 4 Baby Blues
- Choices
- Public and Private Cord Blood Banks
- The Development of Private Cord Blood Banking
- The Development of Public Cord Blood Banking
- Public or Private Cord Blood Storage?
- Cord Blood Guidance
- Whole or Processed?
- More Questions
- To Clamp or Not to Clamp? That is the Question…
- The UK Royal Colleges
- Umbilical Cord Blood Plasma
- Key Points of Chapter 4
Chapter 5 That's a Nice Vein
- Peripheral Blood Stem Cells
- Potential Problems
- Improved Mobilisation Technology
- Clinical Trials Using Peripheral Blood Stem Cells
- Key Points of Chapter 5
Chapter 6 The Vatican and More
- A Complex Debate
- Human Embryonic Stem Cell Production
- The Human Embryo
- Is There an Elephant in the Room?
- Clinical Trials
- A Final Note of Optimism!
- Key Points of Chapter 6
Chapter 7 No One Likes the Dentist
- Off to See the Dentist
- Milk and Adult Teeth
- Milk Teeth Collection
- Stem Cells from Adult Teeth
- Are There Enough Stem Cells?
- Tooth Implants
- Clinical Trial
- Key Points of Chapter 7
Chapter 8 Who are You Calling Fat?
- Fat: Good or Bad?
- Liposuction
- Processing of Fat Stem Cells Using Enzymes
- Processing of Fat Stem Cells Using a Mechanical Approach
- Caution is Needed
- Clinical Trials and ‘Freeze Young’
- Fat Stem Cells and Osteoarthritis
- Key Points of Chapter 8
Chapter 9 a Human Touch
- Man-Made
- Good or Bad?
- Organoids
- Clinical Trials
- Key Points of Chapter 9
Chapter 10 Baby is Back!
- Stem Cells in Tissues Related to Pregnancy
- Umbilical Cord Tissue
- Clinical Trials of Cord Tissue Stem Cells
- Placenta Stem Cells
- Amniotic Membrane and Amniotic Fluid Stem Cells
- Clinical Trials of Amniotic Membrane Stem Cells
- Research and Clinical Trial of Amniotic Membrane Stem Cells
- Key Points of Chapter 10
Chapter 11 Kill or Cure?
- Stem Cell Treatments (Caveat Emptor: Buyer Beware)
- The Regeneration Promise
- Human Use
- Using Your Own Stem Cells
- Celebrity Endorsement
- There is Hope
- Key Points of Chapter 11
Chapter 12 a Final Thought
- Some Things Work Some Things Do Not
- Cord Blood Transfusion
- Platelet Rich Plasma (PRP)
- Very Small Embryonic Like Stem Cells and Laser Technology
- Cell Reprogramming
- Exosomes
- Quantum Medicine
- Nanotechnology
- 3D Printing
- Skeletal Muscle Stem Cells
- Liver Stem Cells
- Recent Progress in Stem Cell Therapy of Heart Disease
- Anti-Ageing
- A Final Thought
- Key Points of Chapter 12
- Suggested Further Reading
- Useful Links
- Glossary
- Subject Index
Author
- Peter Hollands
