Exercises in Organic Synthesis Based on Synthetic Drugs presents information on topics about the synthesis of biologically active compounds which are used against a range of diseases in both humans and animals. Topics are supplemented by notes and exercises for students to stimulate inquiry and learning in the academic environment.
Readers will be equipped with basic knowledge of synthetic techniques used in organic chemistry and pharmaceutical research and development.
Key Features:
- Presents information about different techniques and strategies for the synthesis of organic compounds
- Covers a broad range of biologically active compounds
- Easy to read topical presentation
- Exercises, with answers, designed for improving concepts in organic synthesis and medicinal chemistry
- Wide range of bibliographic references for further reading and exercises presented, Exercises in Organic Synthesis Based on Synthetic Drugs is an essential textbook for students in beginner level courses in organic chemistry, organic synthesis and medicinal chemistry.
Table of Contents
Chapter 1 How to Build a Drug: Exercises Based on the Concept of Retrosynthetic Analysis
- Introduction
- Protective Groups
- Exercises 1 to 4 - Retrosynthetic Analysis
- Exercise 1 - Two Synthons = Drug
- Example
- Answer
- Exercises
- Answers
- Exercise 2 - Epoxides
- Example
- Answer
- Exercises
- Answers
- Exercise 3 - Piperazine and Related Substances
- Examples
- Answers
- Exercises
- Answers
- Exercise 4 - Aldehydes
- Examples
- Answers
- Exercises
- Answers
- Conclusion of the Exercises 1 to 4 (Retrosynthetic Analysis)
Chapter 2 Organizing Synthetic Routes and Identifying Reagents
- Exercises 5 to 8
- Introduction
- Exercise 5 - Organizing Synthetic Routes
- Example
- Answer
- Exercises
- Ruthenium and Its Complexes as Oxidants
- Mechanism of Wittig-Horner Reaction
- Exercise 6 - Identifying Reagents
- Example
- Answer
- Exercises
- Answers
- Conclusion of the Exercises 5 and 6 (Organizing Synthetic Routes
- And Identifying Reagents)
- References
- Examples
- Answers
- Exercises
- Answers
- Exercise 8 - Completing the Gaps
- Example
- Answer
- Exercises
- Answers
- Conclusion of Exercises 7 and 8 (Identifying Drug Structure And Completing the Gaps) Bibliographic Data of Exercises 1 to 9
Chapter 3 Heteroaromatic Substances
- Five-Membered Rings
- Six-Membered Rings
- Fused Systems
- Example
- Answer
- Mechanism of Reaction
- Exercises
- Answers
- Conclusion
Chapter 4 Hydrazine and Its Derivatives
- Introduction
- Example
- Answer
- Exercises
- Answers
- Conclusion
Chapter 5 Nitriles
- Introduction
- Example
- Answer
- Exercises
- Answers
- Conclusion
Chapter 6 Combinatorial Chemistry
- Introduction
- Example
- Answer
- Mechanism of Reaction
- Exercises
- Answers
- Conclusion
- Reference
Chapter 7 Identifying Drug Structure and Completing the Gaps
- Exercise 7 - Identifying Drug Structure
- Answer
- Important Note
- Exercises
- Answers
- Conclusion
Chapter 8 Click Chemistry
- Introduction
- Example
- Answer
- Exercises
- Answers
- Conclusion
- Suggestions for Reading
Chapter 9 Fluorine in Drug Discovery
- Introduction
- Fluorination Reagents
- Nucleophilic Fluorination for the Introduction of Fluorine Atom Naf, Kf, Hf, and Bu4Nf 211
- Diethylaminosulfur Trifluoride (Dast)
- Nucleophilic Fluorination for the Introduction of the Trifluoromethyl Group
- Eletrophilic Fluorination for the Introduction of Fluorine Atoms
- Electrophilic Fluorination for the Introduction of the Trifluoromethyl Group
- Radical Fluorination
- Classical Examples of the Importance of Fluorine in Drug
- Development
- Fluoroquinolone
- Sitagliptin
- Odanacatib
- Celecoxib
- Example
- Answer
- Exercises
- Answers
- Conclusion
- References
- List of Journals Used and Their Respective Abbreviations
- List of Abbreviations
Chapter 10 Multicomponent Reaction (Mcr)
- Introduction
- Example
- Subject Index
Author
- Marcus Vinícius Nora de Souza
