Chondrosarcoma - Epidemiology Forecast - 2032

Key Highlights:

• Chondrosarcoma is the most common primary bone cancer in adulthood and the second most common primary bone cancer overall, making up around 25% of all malignant bone cancer cases.
• Several histological subtypes of chondrosarcoma have been described, including conventional, dedifferentiated, mesenchymal, and clear-cell Chondrosarcoma. Conventional chondrosarcomas represent ~85% of all chondrosarcomas and can be categorized according to their location in bone into primary central and secondary peripheral chondrosarcomas.
• As per the NCCN Guidelines, nearly 65% of Chondrosarcoma cases are related to isocitrate dehydrogenase (IDH1 or IDH2) mutations.
• The total incident cases of chondrosarcoma in the 7MM comprised approximately 2,300 cases in 2022 and are projected to increase during the forecasted period.

The “Chondrosarcoma - Epidemiology Forecast - 2032” report delivers an in-depth understanding of the Chondrosarcoma, historical and forecasted epidemiology in the United States, EU4 (Germany, Spain, Italy, and France) and the United Kingdom, and Japan.

Geography Covered

• The United States
• EU4 (Germany, France, Italy, and Spain) and the United Kingdom
• Japan

Study Period: 2019-2032

Chondrosarcoma Understanding and Diagnostic Algorithm

Chondrosarcoma Overview

Chondrosarcoma is a group of bone tumors made up of cells that make too much cartilage. The most common type of chondrosarcoma, called conventional chondrosarcoma, usually grows very slowly. Rare subtypes of chondrosarcoma, called dedifferentiated chondrosarcoma, myxoid chondrosarcoma, clear cell chondrosarcoma, and mesenchymal chondrosarcoma, may grow more quickly and may spread to other parts of the body.

They may occur at any age but are more common in older adults. Symptoms of chondrosarcoma are usually mild and depend on tumor size and location.

Chondrosarcoma Diagnosis

The patient's journey begins with symptoms such as persistent bone pain even at rest, swelling, and a large palpable mass on the affected bone. Followed by a visit to the orthopedist, where the patient is suggested diagnostic tests such as MRI, CT scan, and plain radiography. After the diagnosis patient is referred to an oncologist for further treatment. A tissue biopsy is performed of the mass removed from the most aggressive portion of cancer as determined by imaging for confirmatory diagnosis. Once chondrosarcoma is confirmed, relevant treatment is given to the patient.

Chondrosarcoma Epidemiology

As the market is derived using a patient-based model, the Chondrosarcoma epidemiology chapter in the report provides historical as well as forecasted epidemiology segmented by total incident cases of chondrosarcoma, primary chondrosarcoma cases, grade-specific cases of chondrosarcoma, mutation-specific cases of chondrosarcoma, stage-specific cases of conventional chondrosarcoma in the 7MM covering the United States, EU4 countries (Germany, France, Italy, and Spain), United Kingdom, and Japan from 2019 to 2032.

• The total number of incident cases of chondrosarcoma in the United States was around 1,371 cases in 2022.
• The United States contributed to the largest incident population of chondrosarcoma, acquiring ~59% of the 7MM in 2022. Whereas EU4 and the UK, and Japan accounted for around 37% and 4% of the total population share, respectively, in 2022.
• Among the EU4 countries, France accounted for the largest number of Chondrosarcoma cases, followed by Germany, whereas Spain accounted for the lowest number of cases in 2022.
• According to the estimates, in the United States, there were around 485, 584, 177, and 125 cases of Grade I, II, III, and IV, respectively, in 2022.
• Among the stage-specific rates of conventional chondrosarcoma, localized conventional chondrosarcoma accounted for approximately 75% of the patient share, while the rest of them were metastatic in nature
• When it comes to disease progression, the rate is quite high in patients with high-grade conventional chondrosarcoma as compared to the ones with low-grade conventional chondrosarcoma

KOL Views

To keep up with current market trends, we take KOLs and SMEs' opinions working in the domain through primary research to fill the data gaps and validate our secondary research. Industry experts contacted to understand and validate the patient pool, diagnosis gap, evolution in diagnosis and forecasted trends, and unmet need included Medical/scientific writers; Medical Oncologists; Orthopedists, and Professors; MD, FACS, Chair of the Department of Orthopedic Surgery, and professor at UC Davis Comprehensive Cancer Center in Sacramento, California; MD, Director, Sarcoma Oncology Center, California; and others.

The analysts connected with 30+ KOLs to gather insights; however, interviews were conducted with 10+ KOLs in the 7MM.

Scope of the Report

• The report covers a segment of key events, an executive summary, and a descriptive overview of chondrosarcoma, explaining its causes, signs and symptoms, and pathogenesis.
• Comprehensive insight into the country-wise epidemiology segments and forecasts, the future growth potential of diagnosis rate, and insights on disease progression have been provided.
• Patient stratification based on grade-specific and stage-specific cases is an inclusion
• A detailed review of current challenges in establishing the diagnosis

Chondrosarcoma Report Insights

• Chondrosarcoma Patient Population
• Patient Population of Grade I, II, III, and IV
• Country-wise Epidemiology Distribution

Chondrosarcoma Report Key Strengths

• 10 Years Forecast
• The 7MM Coverage
• Chondrosarcoma Epidemiology Segmentation

Chondrosarcoma Report Assessment

• Epidemiology Segmentation
• Current Diagnostic Practices
• Unmet Needs

Key Questions Answered

Epidemiology Insights

• What are the disease risks, burdens, and unmet needs of Chondrosarcoma? What will be the growth opportunities across the 7MM concerning the patient population of Chondrosarcoma?
• What is the historical and forecasted Chondrosarcoma patient pool in the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan?
• Which type of primary Chondrosarcoma is the largest contributor in patients affected with Chondrosarcoma?
• Which grade of Chondrosarcoma have high metastatic potential?
• How many Chondrosarcoma patients are associated with IDH mutations?

Reasons to Buy

• Insights on patient burden/disease, evolution in diagnosis, and factors contributing to the change in the epidemiology of the disease during the forecast years.
• To understand the grade-specific Chondrosarcoma incidence cases in varying geographies over the coming years.
• A detailed overview of stage-specific and type-specific cases of Chondrosarcoma is an inclusion
• To understand the perspective of key opinion leaders around the current challenges with establishing the diagnosis, and insights on the recurrent and treatment-eligible patient pool.
• Detailed insights on various factors hampering disease diagnosis and other existing diagnostic challenges.