End-Stage Renal Disease - Pipeline Insight, 2024

This “End-Stage Renal Disease - Pipeline Insight, 2024,” report provides comprehensive insights about 5+ companies and 5+ pipeline drugs in End-Stage Renal Disease pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

• Global coverage

End-Stage Renal Disease Understanding

End-Stage Renal Disease: Overview

End-stage renal disease, also called end-stage kidney disease, occurs when chronic kidney disease - the gradual loss of kidney function - reaches an advanced state. In end-stage renal disease, the kidneys are no longer able to work as they should to meet the body's needs. End stage renal disease (ESRD) is the last stage (stage five) of chronic kidney disease (CKD). This means kidneys are only functioning at 10 to 15 percent of their normal capacity. When chronic kidney disease develops into ESRD, dialysis or a kidney transplant is necessary to stay alive. ESRD is caused most commonly due to diabetes and hypertension (high blood pressure). The treatments for ESRD are dialysis or a kidney transplant. In some cases, lifestyle changes and medications may help.

End-Stage Renal Disease- Pipeline Insight, 2024 report outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the End-Stage Renal Disease pipeline landscape is provided which includes the disease overview and End-Stage Renal Disease treatment guidelines. The assessment part of the report embraces, in depth End-Stage Renal Disease commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, End-Stage Renal Disease collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

Report Highlights

The companies and academics are working to assess challenges and seek opportunities that could influence End-Stage Renal Disease R&D. The therapies under development are focused on novel approaches to treat/improve End-Stage Renal Disease.

End-Stage Renal Disease Emerging Drugs Chapters

This segment of the End-Stage Renal Disease report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

End-Stage Renal Disease Emerging Drugs

AB002: Aronora, Inc.Mechanism of Action: Protein C stimulants. The phase 2 of clinical trials are going on to study safety and efficacy of AB002 in end stage renal disease patients on chronic hemodialysis.

ISIS 416858: Ionis Pharmaceuticals ISIS 416858 is a Factor XI inhibitor. A phase 2 clinical study evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of ISIS 416858 for participants with ESRD (end stage renal disease) receiving chronic hemodialysis as assessed by FXI activity reduction.

End-Stage Renal Disease: Therapeutic Assessment

This segment of the report provides insights about the different End-Stage Renal Disease drugs segregated based on following parameters that define the scope of the report, such as:

Major Players in End-Stage Renal Disease

There are approx. 5+ key companies which are developing the therapies for End-Stage Renal Disease. The companies which have their End-Stage Renal Disease drug candidates in the mid to advanced stage, i.e. phase III and Phase II include, Aronora Inc., and others.

Phases

This report covers around 5+ products under different phases of clinical development like

• Mid-stage products (Phase II and Phase I/II)
• Early-stage products (Phase I/II and Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates

Route of Administration
End-Stage Renal Disease pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

• Subcutaneous
• Intravenous
• Oral
• Parenteral
• Intramuscular

Molecule Type

Products have been categorized under various Molecule types such as

• Small molecules
• Peptides
• Polymer
• Gene Therapy
• Monoclonal antibodies

Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

End-Stage Renal Disease: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses End-Stage Renal Disease therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging End-Stage Renal Disease drugs.

End-Stage Renal Disease Report Insights

• End-Stage Renal Disease Pipeline Analysis
• Therapeutic Assessment
• Unmet Needs
• Impact of Drugs

End-Stage Renal Disease Report Assessment

• Pipeline Product Profiles
• Therapeutic Assessment
• Pipeline Assessment
• Inactive drugs assessment
• Unmet Needs

Key Questions

Current Treatment Scenario and Emerging Therapies:

• How many companies are developing End-Stage Renal Disease drugs?
• How many End-Stage Renal Disease drugs are developed by each company?
• How many emerging drugs are in mid-stage, and late-stage of development for the treatment of End-Stage Renal Disease?
• What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the End-Stage Renal Disease therapeutics?
• What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
• What are the clinical studies going on for End-Stage Renal Disease and their status?
• What are the key designations that have been granted to the emerging drugs?

Key Players

• Aronora Inc.
• Ionis Pharmaceuticals
• Janssen Research & Development, LLC
• Ardelyx

Key Products

• AZD1722
• AB002
• ISIS 416858
• Rivaroxaban

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