Novel Approaches to Colorectal Cancer, Volume 151 in the Advances in Cancer Research series, is composed of 11 reviews covering state-of-the-art research relating to the etiology, diagnosis, prevention and treatment of colorectal cancer. The book's chapters were written by recognized experts in the field, and include sections on molecular biomarkers in diagnosis and therapy, the interplay of diet, lifestyle, and the microbiome, early-age onset disease, mutational signature analysis, challenges in early detection, immunotherapy, organoid technology, the role of epigenetic alterations, disparities in minority populations, field carcinogenesis, and cancer as an evolutionary process.
Each of these topics provides novel insights and concepts on various aspects of the nature of colorectal cancer, offering new opportunities for the management of a major source of cancer incidence and mortality.
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Table of Contents
1. Early age onset colorectal cancerSwati G. Patel, Caitlin C. Murphy, Christopher H. Lieu, and Heather Hampel
2. Treatment-induced evolutionary dynamics in nonmetastatic locally advanced rectal adenocarcinoma
Seth I. Felder, Jason B. Fleming, and Robert A. Gatenby
2. Early colorectal cancer detection-Current and evolving challenges in evidence, guidelines, policy, and practices
Robert A. Smith, Stacey Fedewa, and Rebecca Siegel
4. Personalized nutrition for colorectal cancer
Kai Wang and Mingyang Song
5. Immunotherapy in colorectal cancer
Parul Agarwal, Dung T. Le, and Patrick M. Boland
6. Racial and ethnic disparities in colorectal cancer incidence and mortality
John M. Carethers
7. Genomic and epigenomic biomarkers in colorectal cancer: From diagnosis to therapy
Juan Ruiz-Ba�obre and Ajay Goel
8. Field carcinogenesis for risk stratification of colorectal cancer
Dionne Rebello, Elliott Rebello, Matthew Custodio, Xixi Xu, Sanil Gandhi, and Hemant K. Roy
9. Modeling colorectal cancers using multidimensional organoids
Ibrahim M. Sayed, Amer Ali Abd El-Hafeez, Priti P. Maity, Soumita Das, and Pradipta Ghosh
10. Unraveling the genomic landscape of colorectal cancer through mutational signatures
Marcos D�az-Gay and Ludmil B. Alexandrov
11. Epigenetic alterations in the gastrointestinal tract: Current and emerging use for biomarkers of cancer
William M. Grady
