- Offers definitive, full-color coverage of basic science, diagnosis, evaluation, and treatment of the full range of respiratory diseases.
- Provides detailed explanations of each disease entity and differential diagnoses with state-of-the-art, evidence-based content by global leaders in the field.
- Contains a newly expanded section on common presentations of respiratory disease, plus new chapters on COVID-19, asthma and obesity, airplane travel, lung cancer screening, noninvasive support of oxygenation, lung microbiome, thoracic surgery, inhaled substances, treatment of lung cancer, and more.
- Covers hot topics such as vaping; advanced ultrasound applications and procedures; interventional pulmonology; immunotherapy; lung cancer targeted therapy; outbreaks, pandemics and bioterrorism; point-of-care ultrasound; use of high-flow oxygen, and more.
- Includes extensively reorganized sections on basic science, pleural disease, and sleep, with new chapters and approaches to the topics.
- Features more than 1,450 anatomic, algorithmic, and radiologic images (400 are new!) including CT, PET, MR, and HRCT, plus extensive online-only content: 200 procedural and conceptual videos plus audio clips of lung sounds.
- Brings you up to date with the latest respiratory drugs, mechanisms of action, indications, precautions, adverse effects, and recommendations, with increased emphasis on algorithms to illustrate decision making.
- Enhanced eBook version included with purchase. Your enhanced eBook allows you access to all of the text, figures, reporting templates, and references from the book on a variety of devices.
Table of Contents
PART 1 SCIENTIFIC PRINCIPLES OF RESPIRATORY MEDICINE
SECTION A Anatomy and Development of the Respiratory Tract
1. Anatomy
2. Lung Growth and Development
3. Alveolar Compartment
4. Airway Biology
5. Lung Mesenchyme
6. Vascular Biology
7. Lymphatic Biology
8. Regeneration and Repair
9. Genetics of Lung Disease
SECTION B Respiratory Physiology
10. Ventilation, Blood Flow, and Gas Exchange
11. Respiratory System Mechanics and Energetics
12. Acid-Base Balance
13. Aerosol and Drug Delivery
14. Pleural Physiology and Pathophysiology
SECTION C Defense Mechanisms and Immunology
15. Innate Immunity
16. Adaptive Immunity
17. Microbiome
PART 2 DIAGNOSIS AND EVALUATION OF RESPIRATORY DISEASE
SECTION D Diagnosis
18. History and Physical Examination
19. Microbiological Diagnosis of Lung Infection
20. Thoracic Radiology: Noninvasive Diagnostic Imaging
21. Thoracic Radiology: Invasive Diagnostic Imaging and Image-Guided Interventions
22. Pathology
23. Ultrasonography: Principles, and Basic Thoracic and Vascular Imaging
24. Ultrasonography: Advanced Applications and Procedures
25. Positron Emission Tomography
26. Diagnostic Bronchoscopy: Basic Techniques
27. Diagnostic Bronchoscopy: Advanced Techniques (EBUS and Navigational)
28. Therapeutic Bronchoscopy: Interventional Techniques
29. Thoracoscopy
30. Thoracic Surgery
SECTION E Evaluation
31. Pulmonary Function Testing: Physiologic and technical principles
32. Pulmonary Function Testing: Interpretation and Applications
33. Exercise Testing
34. Preoperative Evaluation
35. Evaluation of Respiratory Impairment and Disability
PART 3 CLINICAL RESPIRATORY MEDICINE
SECTION F Evaluation of Common Presentations of Respiratory Disease
36. Dyspnea
37. Cough
38. Chest Pain
39. Wheezing and Stridor
40. Hemoptysis
41. Pulmonary Nodule
42. Positive Screening Test for Tuberculosis
43. Aspiration
44. Hypoxemia
45. Hypercarbia
SECTION G Infectious Diseases of the Lungs
46. Community-Acquired Pneumonia
46a. COVID-19
47. Influenza
48. Hospital-Acquired Pneumonia
49. Ventilator-Associated Pneumonia
50. Lung Abscess
51. Tuberculosis: Epidemiology and Prevention
52. Tuberculosis: Pathogenesis and immunity
53. Tuberculosis: Clinical Manifestations and Diagnosis
54. Tuberculosis: Treatment of Drug-Susceptible and Drug-Resistant
55. Nontuberculous Mycobacterial Infections
56. Fungal Infections: Endemic
57. Fungal Infections: Opportunistic
58. Parasitic Infections
59. Outbreaks, Epidemics, and Bioterrorism
SECTION H Obstructive Diseases
60. Asthma: Pathogenesis and Phenotypes
61. Asthma and Obesity
62. Asthma: Diagnosis and Management
63. COPD: Pathogenesis and Natural History
64. COPD: Diagnosis and Management
65. Smoking Hazards: Cigarettes, Vaping, Marijuana
66. Smoking Cessation
67. Cystic Fibrosis: Pathogenesis and Epidemiology
68. Cystic Fibrosis: Diagnosis and Management
69. Bronchiectasis
70. Upper Airway Disorders
71. Large Airway Disorders
72. Bronchiolitis
SECTION I Neoplasms of the Lung
73. Lung Cancer: Molecular Biology and Targets
74. Lung Cancer: Epidemiology
75. Lung Cancer: Screening
76. Lung Cancer: Diagnosis and Staging
77. Lung Cancer: Treatment
78. Rare Primary Lung Tumors
79. Metastatic Malignant Tumors
80. Benign Lung Tumors
SECTION J Disorders of the Pulmonary Circulation
81. Pulmonary Thromboembolism: Presentation and Diagnosis
82. Pulmonary Thromboembolism: Prophylaxis and Treatment
83. Pulmonary Hypertension: General Approach
84. Pulmonary Arterial Hypertension: Group 1
85. Pulmonary Hypertension due to Lung Disease: Group 3
86. Pulmonary Hypertension due to Chronic Thromboembolic Disease: Group 4
87. Pulmonary Vasculitis
88. Pulmonary Vascular Anomalies
SECTION K Infiltrative and Interstitial Lung Diseases
89. Idiopathic Pulmonary Fibrosis
90. Nonspecific Interstitial Pneumonitis and Other Idiopathic Interstitial Pneumonias
91. Hypersensitivity Pneumonitis
92. Connective Tissue Diseases
93. Sarcoidosis
94. Diffuse Alveolar Hemorrhage
95. Pulmonary Langerhans Cell Histiocytosis and other Rare Diffuse Infiltrative Lung Diseases
96. Eosinophilic Lung Diseases
97. Lymphangioleiomyomatosis
98. Pulmonary Alveolar Proteinosis Syndromes
99. Drug-Induced Pulmonary Disease
SECTION L Environmental and Occupational Hazards
100. Asthma in the Workplace
101. Pneumoconioses
102. Indoor and Outdoor Air Pollution
103. Acute Responses to Toxic Exposures
104. Trauma and Blast Injuries
105. High Altitude
106. Air Travel
107. Diving Medicine
SECTION M Disorders of the Pleura
108. Pleural Effusions
109. Pleural Infections
110. Pneumothorax
111. Chylothorax
112. Pleural Fibrosis and Unexpandable Lung
113. Hemothorax
114. Pleural Malignancy
SECTION N Disorders of the Mediastinum
115. Mediastinal Tumors and Cysts
116. Mediastinitis and Fibrosing Mediastinitis
SECTION O Disorders of Sleep and Control of Breathing
117. Control of Breathing and Upper Airways During Sleep
118. Consequences of Sleep Disruption
119. Sleep-Disordered Breathing: General Approach
120. Obstructive Sleep Apnea
121. Central Sleep Apnea
122. Sleep-Disordered Breathing: Treatment
SECTION P Respiratory Manifestations of Extrapulmonary Disorders
123. Pulmonary Complications of HIV Infection
124. Pulmonary Complications of Primary Immunodeficiencies
125. Pulmonary Complications of Stem Cell and Solid Organ Transplantation
126. Pulmonary Complications of Abdominal Diseases
127. Pulmonary Complications of Hematologic Diseases
128. Pulmonary Complications of Endocrine Diseases
129. The Lungs in Obstetric and Gynecologic Diseases
130. The Respiratory System and Neuromuscular Diseases
131. The Respiratory System and Chest Wall Diseases
SECTION Q Management of Respiratory Failure
132. Acute Ventilatory Failure
133. Pulmonary Edema
134. Acute Respiratory Distress Syndrome
135. Mechanical Ventilation
136. Noninvasive Support of Ventilation
137. Noninvasive Support of Oxygenation
138. Extracorporeal Support of Gas Exchange
139. Pulmonary Rehabilitation
140. Lung Transplantation
141. End-of-Life Care in Respiratory Failure
Appendix
Authors
V. Courtney Broaddus Professor EmeritusDivision of Pulmonary and Critical Care
University of California, San Francisco Joel D. Ernst Professor and Chief
Division of Experimental Medicine
University of California, San Francisco Talmadge E. King Jr
Dean, UCSF School of Medicine
Vice Chancellor, Medical Affairs
University of California, San Francisco Stephen C. Lazarus Professor of Medicine, Division of Pulmonary and Critical Care Medicine, Senior Investigator, Cardiovascular Research Institute, Director, Fellowship Program in Pulmonary and Critical Care Medicine, University of California, San Francisco. Kathleen F. SarmientoProfessor
Department of Medicine
University of California, San Francisco
San Francisco, CA
Lynn M. SchnappGeorge R. and Elaine Love Professor
Chair of the Department of Medicine
University of Wisconsin
School of Medicine and Public Health
Madison, WI
Renee D. StapletonProfessor of Medicine, Pulmonary and Critical Care Medicine
Larner College of Medicine
University of Vermont
Michael B. Gotway Professor of Radiology, Department of Diagnostic Imaging, Mayo Clinic, Scottsdale, AZ, Clinical Associate Professor, Departments of, Diagnostic Radiology and Biomedical Imaging, and Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, CA, Clinical Professor, University of Arizona College of Medicine, Phoenix, AZ, Adjunct Professor, Department of Biomedical Informatics, Arizona State University, Tempe, AZ.
