+353-1-416-8900REST OF WORLD
+44-20-3973-8888REST OF WORLD
1-917-300-0470EAST COAST U.S
1-800-526-8630U.S. (TOLL FREE)

Amyloidosis Treatment - Global Strategic Business Report

  • PDF Icon

    Report

  • 89 Pages
  • November 2024
  • Region: Global
  • Global Industry Analysts, Inc
  • ID: 5301894
The global market for Amyloidosis Treatment was estimated at US$6.5 Billion in 2023 and is projected to reach US$10.2 Billion by 2030, growing at a CAGR of 6.6% from 2023 to 2030. This comprehensive report provides an in-depth analysis of market trends, drivers, and forecasts, helping you make informed business decisions.

Global Amyloidosis Treatment Market - Key Trends and Drivers Summarized

Why Is Amyloidosis Treatment Gaining Importance in Medical Research?

Amyloidosis, a rare and complex condition characterized by the abnormal deposition of amyloid proteins in various tissues and organs, has garnered increased attention in the medical community as research advances shed light on more effective treatment strategies. Traditionally, amyloidosis was considered a difficult-to-treat disease, often diagnosed late due to its non-specific symptoms, which can mimic other conditions. The disorder can affect multiple organs, including the heart, kidneys, liver, and nervous system, leading to significant morbidity and mortality if left untreated. However, as the understanding of amyloidosis has evolved so too have the treatment approaches.

Early diagnosis has become critical, as it can greatly improve patient outcomes, and new treatments now target the underlying mechanisms of the disease rather than merely managing symptoms. For example, the use of advanced imaging techniques, such as cardiac MRI and nuclear imaging, has improved diagnostic accuracy, allowing for earlier intervention. One of the main focuses of current research is understanding the different types of amyloidosis, including AL (light-chain) amyloidosis, ATTR (transthyretin) amyloidosis, and AA amyloidosis, as treatment varies depending on the type.

AL amyloidosis, the most common form, involves the abnormal production of light chains by plasma cells, leading to amyloid deposits, while ATTR amyloidosis results from the misfolding of the transthyretin protein, which is primarily produced in the liver. Tailoring treatments to the specific type of amyloidosis is essential, as different therapeutic approaches target the unique pathophysiological processes in each case.

What Sets Modern Amyloidosis Treatments Apart from Conventional Therapies?

Modern amyloidosis treatments represent a significant leap from traditional approaches, primarily because they focus on the root causes of the disease rather than just symptom management. Historically, treatment for amyloidosis was largely supportive, aimed at managing organ dysfunctions caused by amyloid deposits. For example, patients with cardiac amyloidosis were often treated with medications that addressed heart failure symptoms, while those with kidney involvement were managed through dialysis and other supportive measures. However, these treatments did little to halt the progression of the disease or reverse the amyloid deposition.

Today, therapeutic advancements have shifted the focus towards halting or even reversing the deposition of amyloid proteins, leading to improved long-term outcomes. One of the most promising areas in amyloidosis treatment is the development of targeted therapies that address the underlying cause of protein misfolding and deposition. In AL amyloidosis, treatments now focus on reducing the production of abnormal light chains through chemotherapy and proteasome inhibitors, similar to treatments used in multiple myeloma.

In ATTR amyloidosis, new therapies aim to stabilize the transthyretin protein or reduce its production, thereby preventing the formation of amyloid deposits. Drugs like tafamidis, which stabilizes the transthyretin protein, and patisiran, an RNA interference therapy that reduces transthyretin production, have shown significant efficacy in slowing disease progression and improving quality of life.

How Are Technological and Pharmaceutical Advances Improving Amyloidosis Treatment?

Technological and pharmaceutical advances are revolutionizing the treatment of amyloidosis, bringing unprecedented precision and effectiveness to patient care. One of the key breakthroughs is the development of diagnostic technologies that enable earlier detection of the disease, which is crucial for effective treatment. In the past, amyloidosis was often diagnosed late, once significant organ damage had occurred, limiting treatment options and resulting in poor outcomes. Today, advanced imaging techniques, such as echocardiography with strain imaging, cardiac MRI, and nuclear scintigraphy, allow clinicians to detect amyloid deposits in the heart and other organs before significant damage occurs.

Additionally, biopsy techniques, including fat pad aspiration and organ-specific biopsies, have become more sophisticated, enabling definitive diagnoses earlier in the disease process. These advancements in early detection are critical because amyloidosis treatment is most effective when initiated before extensive organ damage takes place. Pharmaceutical innovations have also played a transformative role in amyloidosis treatment. In the realm of AL amyloidosis, new drug regimens targeting the clonal plasma cells responsible for the production of light chains have greatly improved patient outcomes.

Proteasome inhibitors like bortezomib, as well as immunomodulatory drugs, are now part of the standard treatment protocols for AL amyloidosis, often in combination with autologous stem cell transplantation. For ATTR amyloidosis, groundbreaking therapies such as tafamidis and patisiran have emerged as game-changers. Tafamidis works by stabilizing the transthyretin protein, preventing its misfolding, while patisiran reduces the production of transthyretin at the genetic level. These therapies have shown remarkable results in slowing disease progression and improving functional outcomes for patients with both hereditary and wild-type forms of ATTR amyloidosis.

What Are the Key Factors Driving the Growth of the Amyloidosis Treatment Market?

The growth of the amyloidosis treatment market is driven by several key factors, each reflecting advancements in research, diagnostics, and pharmaceutical development. One of the primary drivers is the increasing awareness and recognition of the disease, leading to earlier diagnosis and intervention. Historically, amyloidosis was underdiagnosed due to its non-specific symptoms and the lack of awareness among healthcare providers. However, with advances in diagnostic technologies and a growing understanding of the disease, more patients are being diagnosed earlier, enabling timely treatment and improving outcomes.

The expansion of diagnostic capabilities, particularly with the use of advanced imaging and genetic testing, is allowing for better stratification of amyloidosis patients, which in turn supports the development of more tailored therapeutic approaches. Another major factor contributing to the market's growth is the development of novel therapies that directly target the underlying mechanisms of amyloid deposition. For instance, the introduction of tafamidis for ATTR amyloidosis and the use of proteasome inhibitors in AL amyloidosis have dramatically improved patient outcomes, fueling demand for these drugs.

The aging population, particularly in developed countries, is also driving the growth of the amyloidosis treatment market, as the incidence of amyloidosis - especially ATTR amyloidosis - tends to increase with age. Moreover, regulatory support for the approval of new drugs and therapies has played a pivotal role in expanding treatment options. Lastly, the shift toward personalized medicine and targeted therapies is influencing the amyloidosis treatment landscape.

As researchers continue to uncover the molecular pathways involved in amyloid protein formation and deposition, the potential for gene therapies, monoclonal antibodies, and other innovative treatments is growing. These cutting-edge treatments offer hope not only for slowing disease progression but also for potentially reversing amyloid deposition, marking a new frontier in amyloidosis treatment. As these developments continue, the amyloidosis treatment market is expected to experience significant growth, offering patients better outcomes and more effective management of this challenging condition.

Key Insights:

  • Market Growth: Understand the significant growth trajectory of the Chemotherapy segment, which is expected to reach US$3.7 Billion by 2030 with a CAGR of a 6.2%. The Targeted Therapy segment is also set to grow at 7.6% CAGR over the analysis period.
  • Regional Analysis: Gain insights into the U.S. market, estimated at $1.7 Billion in 2023, and China, forecasted to grow at an impressive 9.6% CAGR to reach $2.3 Billion by 2030. Discover growth trends in other key regions, including Japan, Canada, Germany, and the Asia-Pacific.

Why You Should Buy This Report:

  • Detailed Market Analysis: Access a thorough analysis of the Global Amyloidosis Treatment Market, covering all major geographic regions and market segments.
  • Competitive Insights: Get an overview of the competitive landscape, including the market presence of major players across different geographies.
  • Future Trends and Drivers: Understand the key trends and drivers shaping the future of the Global Amyloidosis Treatment Market.
  • Actionable Insights: Benefit from actionable insights that can help you identify new revenue opportunities and make strategic business decisions.

Key Questions Answered:

  • How is the Global Amyloidosis Treatment Market expected to evolve by 2030?
  • What are the main drivers and restraints affecting the market?
  • Which market segments will grow the most over the forecast period?
  • How will market shares for different regions and segments change by 2030?
  • Who are the leading players in the market, and what are their prospects?

Report Features:

  • Comprehensive Market Data: Independent analysis of annual sales and market forecasts in US$ Million from 2023 to 2030.
  • In-Depth Regional Analysis: Detailed insights into key markets, including the U.S., China, Japan, Canada, Europe, Asia-Pacific, Latin America, Middle East, and Africa.
  • Company Profiles: Coverage of major players in the Global Amyloidosis Treatment Market such as Alnylam Pharmaceuticals, Celgene Corporation, GlaxoSmithKline plc, Ionis Pharmaceuticals, Johnson & Johnson and more.
  • Complimentary Updates: Receive free report updates for one year to keep you informed of the latest market developments.

Some of the 34 companies featured in this Global Amyloidosis Treatment market report include:

  • Alnylam Pharmaceuticals
  • Celgene Corporation
  • GlaxoSmithKline plc
  • Ionis Pharmaceuticals
  • Johnson & Johnson
  • Pfizer
  • Prothena Corporation plc.
  • Takeda

Table of Contents

I. METHODOLOGYII. EXECUTIVE SUMMARY
1. MARKET OVERVIEW
  • Influencer Market Insights
  • World Market Trajectories
  • Global Economic Update
  • Amyloidosis Treatment - Global Key Competitors Percentage Market Share in 2024 (E)
  • Competitive Market Presence - Strong/Active/Niche/Trivial for Players Worldwide in 2024 (E)
2. FOCUS ON SELECT PLAYERS
3. MARKET TRENDS & DRIVERS
  • Growing Prevalence of Amyloidosis Throws the Spotlight on the Need for Advanced Treatment Options
  • Rising Awareness of Rare Diseases Propels Growth in Research and Development for Amyloidosis Therapies
  • Increasing Adoption of Targeted Therapies Strengthens the Business Case for Personalized Amyloidosis Treatment
  • Advances in Genetic Testing and Biomarker Identification Drive Demand for Precision Medicine in Amyloidosis Treatment
  • Expanding Use of Monoclonal Antibodies in Treating Systemic Amyloidosis Spurs Market Growth
  • Development of Novel Small Molecule Drugs Propels Growth in Disease-Modifying Therapies for Amyloidosis
  • Focus on Cardiac Involvement in Amyloidosis Expands Opportunities for Specialized Cardiac Treatments
  • Increasing Availability of Orphan Drug Designations Generates Market Opportunities for Amyloidosis Treatments
  • Rising Use of RNA-Targeting Therapies in Amyloidosis Drives Adoption of Cutting-Edge Therapeutic Approaches
  • Advances in Stem Cell Transplantation Sustain Growth in Curative Approaches for Amyloidosis Treatment
  • Growing Adoption of Combination Therapies Expands the Addressable Market for Amyloidosis Treatment
4. GLOBAL MARKET PERSPECTIVE
  • Table 1: World Recent Past, Current & Future Analysis for Amyloidosis Treatment by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2023 through 2030 and % CAGR
  • Table 2: World Historic Review for Amyloidosis Treatment by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2014 through 2022 and % CAGR
  • Table 3: World 16-Year Perspective for Amyloidosis Treatment by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets for Years 2014, 2024 & 2030
  • Table 4: World Recent Past, Current & Future Analysis for Chemotherapy by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2023 through 2030 and % CAGR
  • Table 5: World Historic Review for Chemotherapy by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2014 through 2022 and % CAGR
  • Table 6: World 16-Year Perspective for Chemotherapy by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2024 & 2030
  • Table 7: World Recent Past, Current & Future Analysis for Targeted Therapy by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2023 through 2030 and % CAGR
  • Table 8: World Historic Review for Targeted Therapy by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2014 through 2022 and % CAGR
  • Table 9: World 16-Year Perspective for Targeted Therapy by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2024 & 2030
  • Table 10: World Recent Past, Current & Future Analysis for Surgery by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2023 through 2030 and % CAGR
  • Table 11: World Historic Review for Surgery by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2014 through 2022 and % CAGR
  • Table 12: World 16-Year Perspective for Surgery by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2024 & 2030
  • Table 13: World Recent Past, Current & Future Analysis for Stem Cell Transplant by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2023 through 2030 and % CAGR
  • Table 14: World Historic Review for Stem Cell Transplant by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2014 through 2022 and % CAGR
  • Table 15: World 16-Year Perspective for Stem Cell Transplant by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2024 & 2030
  • Table 16: World Recent Past, Current & Future Analysis for Supportive Care by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2023 through 2030 and % CAGR
  • Table 17: World Historic Review for Supportive Care by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2014 through 2022 and % CAGR
  • Table 18: World 16-Year Perspective for Supportive Care by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2024 & 2030
  • Table 19: World Amyloidosis Treatment Market Analysis of Annual Sales in US$ Million for Years 2014 through 2030
  • Table 20: World Recent Past, Current & Future Analysis for Other Type by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2023 through 2030 and % CAGR
  • Table 21: World Historic Review for Other Type by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2014 through 2022 and % CAGR
  • Table 22: World 16-Year Perspective for Other Type by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2024 & 2030
  • Table 23: World Recent Past, Current & Future Analysis for Light-chain (AL) amyloidosis by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2023 through 2030 and % CAGR
  • Table 24: World Historic Review for Light-chain (AL) amyloidosis by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2014 through 2022 and % CAGR
  • Table 25: World 16-Year Perspective for Light-chain (AL) amyloidosis by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2024 & 2030
  • Table 26: World Recent Past, Current & Future Analysis for AA amyloidosis by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2023 through 2030 and % CAGR
  • Table 27: World Historic Review for AA amyloidosis by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2014 through 2022 and % CAGR
  • Table 28: World 16-Year Perspective for AA amyloidosis by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2024 & 2030
  • Table 29: World Recent Past, Current & Future Analysis for Dialysis-Related Amyloidosis by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2023 through 2030 and % CAGR
  • Table 30: World Historic Review for Dialysis-Related Amyloidosis by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2014 through 2022 and % CAGR
  • Table 31: World 16-Year Perspective for Dialysis-Related Amyloidosis by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2024 & 2030
  • Table 32: World Recent Past, Current & Future Analysis for Transthyretin amyloidosis (ATTR) by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2023 through 2030 and % CAGR
  • Table 33: World Historic Review for Transthyretin amyloidosis (ATTR) by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Million for Years 2014 through 2022 and % CAGR
  • Table 34: World 16-Year Perspective for Transthyretin amyloidosis (ATTR) by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2024 & 2030
III. MARKET ANALYSIS
UNITED STATES
  • Amyloidosis Treatment Market Presence - Strong/Active/Niche/Trivial - Key Competitors in the United States for 2024 (E)
CANADA
JAPAN
  • Amyloidosis Treatment Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Japan for 2024 (E)
CHINA
  • Amyloidosis Treatment Market Presence - Strong/Active/Niche/Trivial - Key Competitors in China for 2024 (E)
EUROPE
  • Amyloidosis Treatment Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Europe for 2024 (E)
FRANCE
  • Amyloidosis Treatment Market Presence - Strong/Active/Niche/Trivial - Key Competitors in France for 2024 (E)
GERMANY
  • Amyloidosis Treatment Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Germany for 2024 (E)
ITALY
UNITED KINGDOM
  • Amyloidosis Treatment Market Presence - Strong/Active/Niche/Trivial - Key Competitors in the United Kingdom for 2024 (E)
SPAINRUSSIAREST OF EUROPE
ASIA-PACIFIC
  • Amyloidosis Treatment Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Asia-Pacific for 2024 (E)
AUSTRALIA
  • Amyloidosis Treatment Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Australia for 2024 (E)
INDIA
  • Amyloidosis Treatment Market Presence - Strong/Active/Niche/Trivial - Key Competitors in India for 2024 (E)
SOUTH KOREAREST OF ASIA-PACIFIC
LATIN AMERICA
  • Amyloidosis Treatment Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Latin America for 2024 (E)
ARGENTINABRAZILMEXICOREST OF LATIN AMERICA
MIDDLE EAST
  • Amyloidosis Treatment Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Middle East for 2024 (E)
IRANISRAELSAUDI ARABIAUNITED ARAB EMIRATESREST OF MIDDLE EAST
AFRICA
  • Amyloidosis Treatment Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Africa for 2024 (E)
IV. COMPETITION

Companies Mentioned

Some of the 34 companies featured in this Global Amyloidosis Treatment market report include:
  • Alnylam Pharmaceuticals
  • Celgene Corporation
  • GlaxoSmithKline plc
  • Ionis Pharmaceuticals
  • Johnson & Johnson
  • Pfizer
  • Prothena Corporation plc.
  • Takeda

Table Information