The Neurobiology of Aging and Alzheimer Disease in Down Syndrome provides a multidisciplinary approach to the understanding of aging and Alzheimer disease in Down syndrome that is synergistic and focused on efforts to understand the neurobiology as it pertains to interventions that will slow or prevent disease. The book provides detailed knowledge of key molecular aspects of aging and neurodegeneration in Down Syndrome by bringing together different models of the diseases and highlighting multiple techniques. Additionally, it includes case studies and coverage of neuroimaging, neuropathological and biomarker changes associated with these cohorts. This is a must-have resource for researchers who work with or study aging and Alzheimer disease either in the general population or in people with Down syndrome, for academic and general physicians who interact with sporadic dementia patients and need more information about Down syndrome, and for new investigators to the aging and Alzheimer/Down syndrome arena.
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Table of Contents
1. Introduction 2. Alzheimer's neuropathology in Down syndrome: From gestation to old age 3. The contribution of inflammation to Alzheimer's disease in Down syndrome 4. The role of cerebrovascular disease in aging and Alzheimer's disease among people with Down syndrome 5. Oxidative stress and mTOR in Down syndrome brain: Link to Alzheimer's dysmetabolism, neuropathology, and possible therapies 6. Fluid biomarkers for Alzheimer's disease in Down syndrome: Current status and novel trends 7. Proteomic and metabolomic biomarkers of Alzheimer's disease: Opportunities to advance precision medicine and clinical trials 8. Magnetic resonance imaging biomarkers for cognitive decline in Down syndrome 9. PET imaging in Down syndrome and Alzheimer's disease 10. Genetics of Alzheimer's disease in adults with Down syndrome 11. Co-occurring medical conditions in aging adults with Down syndrome 12. Sleep in aging adults with Down syndrome and its association with Alzheimer's disease 13. Contributions of the neurological examination to the diagnosis of dementia in Down syndrome 14. Psychiatric issues in aging and dementia 15. Cognitive profile of aging and dementia 16. Clinical trials for Alzheimer's disease in Down syndrome 17. Future directions
Index
Authors
Elizabeth Head Professor and Vice Chair for Research, Department of Pathology & Laboratory Medicine,University of California, Irvine, CA, United States. Dr. Head received a Masters in Psychology and a Ph.D. in Neuroscience from the University of Toronto, Canada. She received postdoctoral training at the Institute for Brain Aging & Dementia at the University of California - Irvine. Dr. Head moved to the University of Kentucky in January of 2009 and was a Professor and Associate Director of Education at the Sanders-Brown Center on Aging. In 2019, she returned to the University of California at Irvine, where she is a Professor and Vice Chair for Research in the Department of Pathology & Laboratory Medicine. Dr. Head has dedicated over 20 years to the study of aging and Alzheimer's disease with a focus on people with Down syndrome. The goal of her research is to help develop interventions that will promote healthy aging in people with Down syndrome. Ira Lott Founding Director, Down Syndrome Program, University of California, Irvine, CA, USA. Dr. Lott is an Emeritus Professor of Pediatrics and Neurology at the University of California, Irvine. His training was at the Massachusetts General Hospital, Harvard Medical School and he was appointed as the first Clinical Director of the Eunice Kennedy Shriver Center for people with intellectual disability. Since his recruitment to UCI in 1983, he has served as Division chief in pediatric neurology, Chair of Pediatrics and Associate Dean for Clinical Neuroscience. Dr. Lott's research on development and aging in people with Down syndrome has been continuously funded by the National Institutes of Health for over 25 years. He has received award recognition for his work at the international, national and state levels. Having trained generations of medical students and resident physicians, Dr. Lott's approach focuses on the intersection between neuroscience and clinical practice.
