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Biosensor Based Advanced Cancer Diagnostics. From Lab to Clinics

  • Book

  • August 2021
  • Elsevier Science and Technology
  • ID: 5308595
Early diagnosis of cancer and other non-oncological disorders gives a significant advantage for curing the disease and improving patient's life expectancy. Recent advances in biosensor-based techniques which are designed for specific biomarkers can be exploited for early diagnosis of diseases. Biosensor Based Advanced Cancer Diagnostics covers all available biosensor-based approaches and comprehensive technologies; along with their application in diagnosis, prognosis and therapeutic management of various oncological disorders. Besides this, current challenges and future aspects of these diagnostic approaches have also been discussed. This book offers a view of recent advances and is also helpful for designing new biosensor-based technologies in the field of medical science, engineering and biomedical technology.

Biosensor Based Advanced Cancer Diagnostics helps biomedical engineers, researchers, molecular biologists, oncologists and clinicians with the development of point of care devices for disease diagnostics and prognostics. It also provides information on developing user friendly, sensitive, stable, accurate, low cost and minimally invasive modalities which can be adopted from lab to clinics. This book covers in-depth knowledge of disease biomarkers that can be exploited for designing and development of a range of biosensors. The editors have summarized the potential cancer biomarkers and methodology for their detection, plus transferring the developed system to clinical application by miniaturization and required integration with microfluidic systems.

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Table of Contents

1. Introduction: Background, state-of-art for design and development of biosensor-based techniques strategy2. Types of Biomarkers associated with cancer and other disease associated health risk factors3. Basic concept for Biosensor-based devices4. Type of Biosensors-based on Biorecognition element5. Type of Biosensors-based on transducers6. Multidisciplinary approach to device design7. Fabrication technique of Biosensor-devices 8. Lab-on-chip devices-based type of cancer cell targeting9. Challenges and future prospects and commercial viability of Biosensor-based diagnosis

Authors

Raju Khan Industrial Waste Utilization, Nano and Biomaterials, CSIR-Advanced, Materials and Processes, Research Institute (AMPRI), Bhopal, Madhya, Pradesh, India. Raju Khan, FRSC, is a Senior Principal Scientist & Professor, CSIR - Advanced Materials and Processes Research Institute (AMPRI), Bhopal, MP, India. He has more than 15 years of experience in electrochemistry to explore electrochemical properties of nanostructure materials to design and develop efficient biosensor devices integrated with microfluidics for biomedical applications. Arpana Parihar Industrial Waste Utilization, Nano and Biomaterials, CSIR-Advanced, Materials and Processes, Research Institute (AMPRI), Bhopal, Madhya, Pradesh, India. Arpana Parihar is a DST Scientist B at CSIR-Advanced Materials and Processes Research Institute (AMPRI), Bhopal, India. She has 8 years of research and teaching experience and her current research interests include fabrication (Micro/Nano-fabrication) of Bio-devices/bio-medical POCT Devices for early diagnosis of cancer and infectious disease. She has gained significant expertise in the field of 3D cell culture, drug designing, tissue engineering, photodynamic therapy, molecular dynamic simulations, and immunoinformatics. S.K. Sanghi Chief Scientist & Head, Microfluidics & MEMS Centre & Materials for Radiation Shielding and Cement free Concrete CSIR-Advanced Materials and Processes Research Institute (AMPRI), India.. Sunil Kumar Sanghi was working as Chief Scientist, Professor and head at Microfluidics & MEMS Centre, CSIR-Advanced Materials and Processes Research Institute, Bhopal, India. His past research areas were development of manual and automated procedures for all kinds of analytes in biomedical, pharmaceutical and environmental samples using micro liquid, capillary gas chromatographic and capillary electrophoretic separation techniques in combination with sample preparation, derivatization and reaction-detection systems, micro-chip-based separation under the concept of lab-on-a-chip. Dr. Sanghi has successfully completed several International and national collaborative R & D projects viz. Indo- European Union, Indo - French, NMITLI etc. He was awarded the reputed Marie Curie Fellowship of European Union, and worked as a visiting scientist for three years at the University of Amsterdam and Institute Curie, Paris. He holds an experience of 35 years in R&D and teaching. Recently, Dr. Sanghi has received the National Meritorious Innovation Award 2021 from Government of India.