Micro and Nano Systems for Biophysical Studies of Cells and Small Organisms provides a comprehensive introduction to the state-of-the-art micro and nano systems that have recently been developed and applied to biophysical studies of cells and small organisms. These micro and nano systems span from microelectromechanical systems (MEMS) and microfluidic devices to robotic micro-nanomanipulation systems. These biophysical studies range from cell mechanics to the neural science of worms and Drosophila. This book will help readers understand the fundamentals surrounding the development of these tools and teach them the most recent advances in cellular and organismal biophysics enabled by these technologies.
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Table of Contents
1. Micro systems for probing cellular forces and cellular mechanical properties 2. Force-sensing micropillar arrays for cell mechanics and mechanobiology 3. Vertical nanostructures for probing live cells 4. Probing tissue mechanics at the cellular length-scale in cancer microenvironments 5. Advanced microfluidic devices for cell electroporation and manipulation 6. High-throughput three-dimensional cellular platforms for screening biophysical microenvironmental signals 7. Acoustofluidic technology for cell biophysics 8. Microfluidic devices for neutrophil migration studies 9. Field-controlled micro-nano manipulations and micro-nano robots 10. Robotic optical tweezers for cell biophysics 11. Robotic and microfluidic systems for single cell injection 12. Biophysical phenotyping of C. elegans in a microfluidic chip for high-throughput drug screening 13. Microfluidic devices for imaging and manipulation of C. elegans 14. Micro systems for the study of behavioral responses of C. elegans to various physical and chemical stimuli 15. Microfluidic devices to study the effect of electric fields on C. elegans and Danio rerio 16. Force-controlled robotic systems for mechanical stimulation of Drosophila larvae
Authors
Xinyu Liu Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, Canada. Xinyu Liu?is the Percy Edward Hart Professor of Mechanical and Industrial Engineering at the University of Toronto. Prior to joining the University of Toronto, he was an Associate Professor and the Canada Research Chair in Microfluidics and BioMEMS in the Department of Mechanical Engineering at McGill University. His research focuses on microfluidics, bioMEMS, and soft and micro robotics, with applications primarily in medicine and biology. He received the Canadian Rising Star in Global Health Award, the Douglas R. Colton Metal for Research Excellence, the McGill Christophe Pierre Award for Research Excellence, the MINE Outstanding Young Researcher Award, and seven best paper awards at major engineering and biomedical conferences. He is a fellow of the American Society of Mechanical Engineers. Yu Sun Professor, Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, Canada.Dr. Yu Sun is a Professor at the University of Toronto. He holds a Tier I Canada Research Chair and is the founding Director of Robotic Institute at the University of Toronto. His Advanced Micro and Nanosystems Laboratory specializes in developing innovative robotic and AI technologies for reproductive medicine. His techniques have been applied in clinical centers from multiple countries.
