Glucagon-Like Peptide 1 Receptor Agonists - Pipeline Insight, 2024

This “Glucagon-Like Peptide 1 Receptor Agonists - Pipeline Insight, 2024” report provides comprehensive insights about 30+ companies and 30+ pipeline drugs in Glucagon-Like Peptide 1 Receptor Agonists pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

• Global coverage

Glucagon-Like Peptide 1 Receptor Agonists Understanding

Glucagon-Like Peptide 1 Receptor Agonists: Overview

The human Glucagon-Like Peptide 1 Receptor (GLP-1) receptor is located on chromosome 6 (6p21). The GLP-1 receptor sequence contains a large hydrophilic extracellular domain and seven hydrophobic transmembrane domains. Glucagon-like peptide-1 amide (GLP-1) is a 30-residue peptide hormone released from intestinal L cells following nutrient consumption. It potentiates the glucose-induced secretion of insulin from pancreatic beta cells, increases insulin expression, inhibits beta-cell apoptosis, promotes beta-cell neogenesis, reduces glucagon secretion, delays gastric emptying, promotes satiety and increases peripheral glucose disposal. These multiple physiological effects make it an attractive candidate for type 2 diabetes therapy. Glucagon-like peptide-1 agonists are a class of medications utilized in the treatment of type 2 diabetes and obesity.

Report Highlights

The companies and academics are working to assess challenges and seek opportunities that could influence Glucagon-Like Peptide 1 Receptor Agonists R&D. The therapies under development are focused on novel approaches for Glucagon-Like Peptide 1 Receptor Agonists.

Glucagon-Like Peptide 1 Receptor Agonists Emerging Drugs Chapters

This segment of the Glucagon-Like Peptide 1 Receptor Agonists report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Glucagon-Like Peptide 1 Receptor Agonists Emerging Drugs

IBI-362: Innovent Biologics IBI362 is a long-acting synthetic peptide related to mammalian oxyntomodulin (OXM). Similar to OXM, IBI362 binds to and activates both the glucagon-like peptide -1 receptor (GLP-1R) and the glucagon receptor (GCGR). IBI362 uses a fatty acid side chain to prolong the duration of action and allow once-weekly administration. Innovent entered into a licensing agreement with Eli Lilly and Company (Lilly) for the development and potential commercialization of OXM3 in China (IBI362), and Lilly is developing it outside China. IBI-362 has the potential to be developed as an important therapy for diabetes, obesity and potentially nonalcoholic steatohepatitis (NASH), and may provide a more effective treatment regimen for overweight and obesepatients.

Tirzepatide: Eli Lilly and Company Tirzepatide is a once-weekly acylated, long-acting dual glucose-dependent insulinotropic peptide (GIP) and a glucagon-like-peptide 1 (GLP-1) receptor agonist. It integrates the actions of both incretins into a single novel molecule. In preclinical models, GIP has been shown to decrease food intake and increase energy expenditure therefore resulting in weight reductions, and when combined with a GLP-1 receptor agonist, may result in greater effects on glucose and body weight. Tirzepatide is in phase III development for blood glucose management in adults with type 2 diabetes and for chronic weight management. It is also being studied as a potential treatment for non-alcoholic steatohepatitis(NASH).

Glucagon-Like Peptide 1 Receptor Agonists: Therapeutic Assessment

This segment of the report provides insights about the different Glucagon-Like Peptide 1 Receptor Agonists drugs segregated based on following parameters that define the scope of the report, such as:

Major Players working on Glucagon-Like Peptide 1 Receptor Agonists

There are approx. 30+ key companies which are developing the Glucagon-Like Peptide 1 Receptor Agonists. The companies which have their Glucagon-Like Peptide 1 Receptor Agonists drug candidates in the most advanced stage, i.e. Phase III include, Eli Lilly and Company.

Phases

This report covers around 30+ products under different phases of clinical development like

• Late-stage products (Phase III and
• Mid-stage products (Phase II and
• Early-stage products (Phase I/II and Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates

Route of Administration

Glucagon-Like Peptide 1 Receptor Agonists pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

• Infusion
• Intradermal
• Intramuscular
• Intranasal
• Intravaginal
• Oral
• Parenteral
• Subcutaneous
• Topical

Molecule Type

Products have been categorized under various Molecule types such as

• Vaccines
• Monoclonal Antibody
• Peptides
• Polymer
• Small molecule

Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Glucagon-Like Peptide 1 Receptor Agonists: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses Glucagon-Like Peptide 1 Receptor Agonists therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Glucagon-Like Peptide 1 Receptor Agonists drugs.

Glucagon-Like Peptide 1 Receptor Agonists Report Insights

• Glucagon-Like Peptide 1 Receptor Agonists Pipeline Analysis
• Therapeutic Assessment
• Unmet Needs
• Impact of Drugs

Glucagon-Like Peptide 1 Receptor Agonists Report Assessment

• Pipeline Product Profiles
• Therapeutic Assessment
• Pipeline Assessment
• Inactive drugs assessment
• Unmet Needs

Key Questions

Current Scenario and Emerging Therapies:

• How many companies are developing Glucagon-Like Peptide 1 Receptor Agonists drugs?
• How many Glucagon-Like Peptide 1 Receptor Agonists drugs are developed by each company?
• How many emerging drugs are in mid-stage, and late-stage of development for Glucagon-Like Peptide 1 Receptor Agonists?
• What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Glucagon-Like Peptide 1 Receptor Agonists therapeutics?
• What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
• What are the clinical studies going on for Glucagon-Like Peptide 1 Receptor Agonists and their status?
• What are the key designations that have been granted to the emerging drugs?

Key Players

• Eli Lilly and Company
• Innovent Biologics
• Novo Nordisk
• AstraZeneca
• Biolingus
• D and D Pharmatech
• Terns Pharmaceuticals
• i2O Therapeutics

Key Products

• Tirzepatide
• IBI-362
• Semaglutide subcutaneous
• Exenatide
• Liraglutide biobetter
• Exenatide/insulin sublingual
• DD-02
• GLP-1R agonist therapeutic
• GLP1 analogs

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