This reference comprehensively covers the clinical aspects of head and neck neoplasms while also highlighting the relationship that exists between inflammation and these cancers. This relationship is critical as it dictates the risks, assessment, treatment, and prognosis of head and neck cancer patients.
The book starts with an introduction to the inflammation ecosystem in head and neck malignancy, followed by detailed discussions on the types of head and neck cancers and their histological classification. The book then provides information about specialized topics relevant to the speciality of head and neck oncology.
Key Features:
- Comprehensive coverage of head and neck cancers with topic-based chapters
- Introductory text explaining the basics of inflammation
- Detailed information on the relationship between inflammation and head and neck neoplasms
- Information about the classification of head and neck cancers
- Methods for diagnosis and treatment
- Special topics such as complications caused by HPV infections, chemoradiation, immune-targeted therapy and inflammatory biomarkers
- References for further reading
The combination of basic and advanced topics makes this book an informative reference for medical students and professionals at all levels. Residents specializing in otolaryngology, oncology, and surgery as well as researchers studying inflammation will also gain an understanding of the subject in relation to oncogenesis.
Table of Contents
Chapter 1 Introduction To Inflammation Ecosystem In Head And Neck Cancer
- Introduction
- Inflammation And Cancer
- Inflammation Ecosystem And Carcinogenesis
- Inflammation And Association With Genetic Changes
- Intratumoural Heterogeneity
- Macrophages And Its Roles In Inflammation Ecosystem
- Risk Factors Of Head And Neck Malignancy And Role Of
- Inflammation
- Growth Factors And Inflammation Ecosystem
- Interaction Between Mediators In The Tumor Microenvironments
- Role Of Inflammatory Markers And Their Critical Action
- Therapeutics
- Prevention Of Head And Neck Malignancy With Anti-Inflammation Agents
- Prognostications Of Head And Neck Malignancy
- The Negative Impact Of Inflammation For Future Research Consideration
- Future Prospect In The Head And Neck Malignancy Management
- Conclusion
- Consent For Publication
- Conflict Of Interest
- Acknowledgements
- References
Chapter 2 Types Of Head And Neck Malignancy
- Introduction
- Epidemiology Of Head & Neck Cancer
- Types Of Head And Neck Cancer
- Laryngeal And Hypopharyngeal Cancer
- Laryngeal Cancer
- Hypopharyngeal Cancer
- Oral Cavity And Oropharyngeal Cancer
- Oral Cavity Cancer
- Oropharyngeal Cancer
- Salivary Gland Malignancy
- Nasal And Paranasal Sinus Cancer
- Nasopharyngeal Cancer
- Thyroid Malignancy
- Metastatic Carcinoma Of Unknown Primary (Mcup)
- Lymphoma
- Miscellaneous: Esophageal, Cutaneous, Temporal Bone Cancer
- Carcinoma Of The Cervical Esophagus
- Norhafiza Mat Lazim
- Gabriela Ramírez-Arroyo, Juan Carlos Hernaiz-Leonardo, Michelle Marvin-Huergo And
- Mario Sergio Dávalos-Fuentes
- Skin Cancer
- Temporal Bone Carcinoma
- Molecular And Genomic Landscape Of Head And Neck Malignancy
- Laryngeal Cancer
- Oropharyngeal Cancer
- Thyroid Cancer
- Lymphoma
- Conclusion
- Consent For Publication
- Conflict Of Interest
- Acknowledgements
- References
Chapter 3 Histological Classification Of Head And Neck Tumors
- Introduction
- Histopathological Classification Of Tumour
- Epithelial Tumour With Squamous Differentiation
- Keratinising Squamous Cell Carcinoma (Kscc)
- Clinical Features
- Morphology
- Non-Keratinizing Squamous Cell Carcinoma (Nkscc)
- Clinical Features
- Morphology
- Prognosis And Predictive Factors
- Squamous Cell Carcinoma – Hpv Positive
- Clinical Features
- Morphology
- Prognosis And Predictive Factor
- Squamous Cell Carcinoma – Hpv Negative
- Verrucous Carcinoma
- Morphology
- Prognosis And Predictive Factor
- Basaloid Squamous Cell Carcinoma
- Morphology
- Prognosis And Predictive Factor
- Papillary Squamous Cell Carcinoma
- Morphology
- Prognosis And Predictive Factor
- Spindle Cell Squamous Cell Carcinoma
- Morphology
- Prognosis And Predictive Factors
- Adenosquamous Carcinoma (Asc)
- Clinical Features
- Morphology
- Prognosis And Predictive Factors
- Nut Carcinoma
- Clinical Features
- Morphology
- Nasopharyngeal Carcinoma
- Epithelial Tumour Without Squamous Differentiation
- Sharifah Emilia Tuan Sharif And Anani Aila Mat Zin
- Sinonasal Papilloma (Schneiderian)
- Precursor/Risk Factors
- Morphology
- Molecular/Genetic Profile
- Prognosis And Predictive Factors
- Ameloblastoma
- Clinical Features
- Morphology
- Molecular/Genetic Profile
- Prognosis/Predictive Factors
- Sinonasal Undifferentiated Carcinoma
- Precursor/Risk Factor
- Morphology
- Molecular/Genetic Profile
- Prognosis/Predictive Factors
- Sinonasal Adenocarcinoma, Intestinal Type
- Precursor/Risk Factors
- Morphology
- Molecular/Genetic Profile
- Prognosis/Predictive Factors
- Salivary Gland Tumour
- Microscopic Anatomy Of Salivary Glands
- Neoplasm Of Salivary Glands
- Benign And Malignant Epithelial Neoplasm
- Pleomorphic Adenoma
- Precursor/Risk Factors
- Morphology
- Molecular/Genetic Profile
- Prognosis/Predictive Factors
- Warthin Tumor (Papillary Cystadenoma Lymphomatosum)
- Precursor/Risk Factors
- Morphology
- Prognosis/Predictive Factors
- Mucoepidermoid Carcinoma
- Morphology
- Molecular/Genetic Profile
- Prognosis And Predictive Factors
- Adenoid Cystic Carcinoma
- Morphology
- Genetic And Prognosis
- Acinic Cell Carcinoma
- Morphology
- Prognosis And Predictive Factors
- Miscellaneous Tumor
- Soft Tissue Tumors And Bone Tumors
- Soft Tissue Tumors
- Biphenotypic Sinonasal Sarcoma
- Nasopharyngeal Angiofibroma
- Spindle Cell/Pleomorphic Lipoma
- Bone Tumors
- Osteosarcoma
- Chondrosarcoma
- Chordoma
- Hematolymphoid Tumours
- Extranodal Nk/T Cell Lymphoma, Nasal Type (Enktl)
- Cd30-Positive T-Cell Lymphoproliferative Disorder
- Neuroendocrine Carcinoma
- Laryngeal Neuroendocrine Carcinomas
- Sinonasal Neuroendocrine Carcinomas
- Paraganglion Tumours
- Thyroid Neoplasm
- Follicular Adenoma
- Malignant Thyroid Neoplasm
- Conclusion
- Consent For Publication
- Conflict Of Interest
- Acknowledgements
- References
Chapter 4 Inflammation, Risk Factors And Etiopathogenesis Of Head And Neck Cancer
- Introduction
- Epidemiology And Survival Rates Of Head And Neck Malignancy
- Risk Factors Of Head And Neck Malignancy And Roles Of
- Inflammation
- Smoking As A Risk Factor For Head And Neck Malignancy
- Alcohol And Its Roles In Head And Neck Malignancy
- Human Papilloma Virus (Hpv) As A Risk Factor For Head And Neck Malignancy
- Epstein Barr Virus (Ebv) And The Inflammation
- Dietary Factors And The Risk Of Head And Neck Malignancy
- Genetic And Familial Inheritance In Head And Neck Malignancy
- Chemical Carcinogen And Risk Of Inflammation
- The Interaction Of Risk Factors In Promoting Inflammation And
- Carcinogenesis
- Smoking, Alcohol, And Oncogenic Viruses
- Smoked Fish, Genetic And Ebv
- Obesity
- Human Papilloma Virus Hpv And Inflammations
- Pathogenesis Of Inflammation And Overall Effects On The Head
- And Neck Malignancy
- Conclusion
- Consent For Publication
- Conflict Of Interest
- Acknowledgements
- References
Chapter 5 The Diagnostic Tools For Head And Neck Cancer
- Introduction To Diagnostic Investigations In Head And Neck
- Cancer
- Norhafiza Mat Lazim
- Giacomo Spinato, Paolo Boscolo Rizzo, Marco Salvatore, Simonetta Ausoni
- Samuele Frasconi, Giuseppe Azzarello, Carlo Cavaliere, Liberatore Tramontano And
- Maria Cristina Da Mosto
- The Anamnesis Role In The Diagnosis
- Clinical Assessment In Head And Neck Cancer
- Clinical Examination In Head And Neck Cancer
- Imaging Tools In Head And Neck
- N Staging For Most Tumours (Except The Nasopharynx And Thyroid)
- N Staging Of Nasopharyngeal Tumours (Midline Nodes Are Considered Ipsilateral)
- N Staging For Thyroid Cancer
- Predictive And Prognostic Biomolecular Tools For Head And Neck
- Cancer
- Biomarkers Related To Viral Etiology
- Biomarkers In The Era Of Target Therapy And Immune Checkpoint Inhibitors
- Conclusions
- Consent For Publication
- Conflict Of Interest
- Acknowledgements
- References
Chapter 6 The Emergence Of New Inflammatory Markers Of Head And Neck Cancer And Their Potentials
- Introduction
- Inflammation As A Primary Cause Of Cancer Progression
- Epidemiology Of Head And Neck Tumour And Inflammation Driven Causes
- Inflammation As A Potent Risk Factor For Head And Neck
- Malignancy
- Significant Inflammatory Markers In Head And Neck Cancer
- Tumor Microenvironment And Inflammatory Markers
- Chemokines And Cytokines
- Immune-Related Effectors
- Role Of Stat3 In Hnscc Cancer Patients
- Role Of Cox2 In Hnscc Cancer Patients
- Role Of Tnf In Hnscc Cancer Patients
- Role Of Vegf In Hnscc Cancer Patients
- Inflammation As An Anti-Cancer Therapeutic Opportunity
- Conclusion
- Consent For Publication
- Conflict Of Interest
- Acknowledgements
- References
Chapter 7 Inflammation And Current Hpv Status In Head And Neck Malignancy
- Introduction
- Chronic Inflammation And Head And Neck Oral Carcinoma
- Oropharyngeal Carcinoma Associated With Hpv
- Human Papilloma Virus (Hpv)
- Epidemiology Of The Hpv Related Hnscc
- Clinical Overview Of Hpv Associated Oropharyngeal Carcinoma 217
- Diagnostic Methods In The Assessment Of Hpv
- Classification Hpv+ Oropharyngeal Carcinoma
Author
- Norhafiza Mat Lazim
