Women's healthcare regarding polycystic ovarian syndrome remains challenging. Patients often go from one specialist to another trying to fully understand and management the disorder. Women often go years before a diagnosis, seeing three or more doctors before a confirmed diagnosis. Polycystic Ovarian Syndrome: Challenging Issues in the Modern Era of Individualized Medicine brings together multiple medical disciplines to improve the care of women with PCOS. Such a multidisciplinary clinical and scientific approach integrates obstetrics and gynecology, pediatric and medical endocrinology, internal medicine, genetics, psychology and laboratory medicine into relevant translational clinical and scientific discussions that update both the scientific understanding of PCOS and the diagnosis and management of all aspects of the syndrome. The impact of PCO on the onset of puberty is subdivided in sub sections to get a better understanding of this condition and the management at different stages in a woman's life.
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Table of Contents
Part I: Polycystic ovary syndrome: Challenges and controversies1. Defining PCOS: A syndrome with an intrinsic heterogeneous nature
HECTOR F. ESCOBAR-MORREALE
2. Secondary PCOS: Well-defined causes, leading to the PCOS phenotype
ALESSANDRA GAMBINERI, CAROLINA CECCHETTI, PAOLA ALTIERI, DANILO RIBICHINI, VALENTINA LO PREIATO, FLAMINIA FANELLI, AND UBERTO PAGOTTO
3. Developmental origins of polycystic ovary syndrome: Everything starts in utero
DAVID H. ABBOTT, EMILY P. GREINWALD, AND JON E. LEVINE
4. The multifarious role of insulin in PCOS: From pathophysiology to therapeutic management
PAOLO MOGHETTI
5. The pathogenic role of androgen excess in PCOS
DUARTE PIGNATELLI, SOFIA S. PEREIRA, AND ELENI KANDARAKI
6. Intrinsic abnormalities of adipose tissue and adipose tissue dysfunction in PCOS
P.M. SPRITZER, B.R. SANTOS, T.M. FIGHERA, L.B. MARCHESAN, AND S.B. LECKE
7. Diet and exercise in the management of PCOS: Starting from the basics
GEORGIOS K. MARKANTES, GINA TSICHLIA, AND NEOKLIS A. GEORGOPOULOS
8. Targeting metabolism in the management of PCOS: Metformin and beyond
SEDA HANIFE OGUZ, SULEYMAN NAHIT SENDUR, UGUR UNLUTURK, AND BULENT OKAN YILDIZ
9. Combined oral contraceptives: Why, when, where?
ATHANASIOS ANTONIOU-TSIGKOS, KONSTANTINA PASTROMA, ELENI MEMI, NIKOLAOS VRACHNIS, AND GEORGE MASTORAKOS
10. Targeting infertility in PCOS: Unfolding "Ariadne's thread�
MARIANO MASCARENHAS AND ADAM H. BALEN
11. Inositols and other supplements in the management of PCOS
VITTORIO UNFER, GIOVANNI MONASTRA, MARCO TILOTTA, GIANPIERO FORTE, AND SIMONA DINICOLA
12. Polycystic ovary syndrome and nonalcoholic fatty liver disease
CARMEN EMANUELA GEORGESCU
13. Cardiometabolic risk in women with PCOS
ENRICO CARMINA
Part II: PCOS and pregnancy: Current concepts?
14. Endocrine-disrupting chemicals and PCOS: A novel contributor in the etiology of the syndrome
EVANTHIA DIAMANTI-KANDARAKIS, OLGA PAPALOU, AND ELENI KANDARAKI
15. Long-term health in women of age more than 40years with polycystic ovary syndrome
ELENI ARMENI AND IRENE LAMBRINOUDAKI
16. Vitamin D metabolism in polycystic ovary syndrome (PCOS)
FLAVIA DI BARI AND SALVATORE BENVENGA
17. The challenging role of antiandrogens in the management of polycystic ovary syndrome
KASIANI PAPADIMITRIOU, PANAGIOTIS ANAGNOSTIS, AND DIMITRIOS G. GOULIS
18. PCOS in adolescence: Pathophysiology, diagnostic challenges, and therapeutic controversies
NICOLAS CRISOSTO
