Vagus Nerve Stimulation

Table of Contents

1. The Vagus nerve, a potent unrecognized modulator of disease and health

Section 2: Basic Science
2. Vagus Nerve Anatomy
3. CNS neurotransmitters
4. CNS hyperexcitability and Pain
5. CNS inflammation
7. Peripheral and Splenic inflammation
8. Liver/Pancreas/kidneys/WAT metabolic
9. Gut inflammation
10. Platelets hemostasis
11. Vagus Nerve Stimulation Approaches in the cervical spine and head
12. Vagus Nerve stimulation approaches in the viscera

Section 3: Neurologic Conditions
13. VNS for Seizure Disorders
14. VNS for Cluster Headaches
15. VNS for Migraine Headaches (Alan Rapaport) include menstrual migraine
16. VNS for Rare Headache Conditions (SUNCT/SUNA/HC/NDPH
17. VNS for Concussion post traumatic headache and Traumatic brain injury

Section 4: Evolving therapy for neurologic conditions
18. VNS for Acute Ischemic Stroke and prevention
19. VNS for Stroke Recovery
20. VNS for Tinnitus
21. VNS To affect Aneurysm growth
22. VNS for Alzheimer's, Multiple Sclerosis and Parkinsons Disease
23. VNS for Cognitive Enhancement
24. VNS for Complex regional Pain Syndrome

Section 5: Psychiatric and Somatic Conditions
25. VNS for Depression
26. VNS for Anxiety
27. VNS for Post-Traumatic Stress Disorder
28. VNS for Fibromyalgia
29. VNS for Visceral Pain
30. VNS for TMD

Section 6: Conventional Inflammatory Conditions
31. VNS and Sepsis
32. VNS and Rheumatoid Arthritis
33. VNS and Sjogren's Disease, Psoriasis and Atopic Dermatitis and Scleroderma
34. VNS and Inflammatory Bowel Disease
35. VNS and Gastroparesis and Ileus
36. VNS and Asthma and cough
37. VNS and Anaphylaxis

Section 7: Metabolic Disease
38. VNS and Diabetes and HTN
39. VNS and NAFLD-NASH
40. VNS and Obesity
41. VNS and Hyperlipidemia

Section 8: Reperfusion Injury
42. VNS and Renal reperfusion injury
43. VNS and Vasculitis Coagulation Syndromes / Cardiac Disease an Multisystem disorders
44. VNS and Hemophilia and bleeding disorders
45. VNS and Myocardial infarction arrhythmia and heart failure
46. The Vagus nerve and cancer protection

Authors

Peter Staats Premier Pain Center, Chief Medical Officer, electroCore, Chief Medical Officer, National Spine and Pain Center, New Jersey, USA. Peter S. Staats, MD, MBA is a board-certified physician specializing in pain medicine. Currently, Dr. Staats is seeing patients at Premier Pain Centers, a pain management practice with seven locations throughout New Jersey. He has been consistently recognized as one of the country's foremost pain management doctors. This includes being named one of America's Top Doctors by U.S. News and World Report for the last decade, noted as being among the top 1% of pain management physicians in the country. He has been acknowledged as one of New Jersey's Top Doctors from New Jersey Monthly magazine for the past seven years. Dr. Staats was also the recipient of the Outstanding Pain Physician award, a national recognition as selected by his peers in the interventional pain medicine community.Dr. Staats is certified by the National Board of Medical Examiners, the American Board of Pain Medicine, and the American Board of Anesthesiology. He is also a fellow of the World Institute of Pain and the North American Neuromodulation Society. He is the author of over 200 articles, abstracts and chapters regarding pain management, and has written several books on the science of pain medicine. Cenk Ayata Assistant Professor,Harvard Medical School; Assistant in Neurology and Neuroscience, Massachusetts General Hospital, Boston, MA, USA. Dr. Ayata is a Neurologist and a clinician-scientist dedicated to translational research on neurovascular function and dysfunction. He explores therapies to augment perfusion and oxygenation in acute stroke (e.g., hyperoxia, induced hypertension, Rho-kinase inhibition), the pathophysiological roles of injury depolarizations in stroke, and targeting spreading depression in migraine. Dr. Ayata is expert in non-invasive in vivo investigations of cerebrovascular physiology and pathophysiology in mice under full systemic physiological control. In collaboration with Dr. Joutel, Dr. Ayata defined a novel enhanced CSD-susceptibility phenotype in Notch3R90C mutant mice, providing an explanation for the increased incidence and severity of migraine with aura in CADASIL patients. Imanuel Lerman Assistant Professor of Anesthesiology, UCSD Center for Pain, La Jolla, CA, USA. Dr. Lerman is a board-certified neurologist who specializes in pain management. He has extensive experience in ultrasound guidance for interventional pain procedures and interventional headache treatment, teaching and speaking nationally on these subjects. As an assistant professor in the Department of Anesthesiology at UC San Diego School of Medicine, Dr. Lerman carries out numerous clinical trials at UC San Diego Medical Center, the Altman Clinical Trial Research Institute, and the VA San Diego Healthcare System. His clinical reasarch studies primarily focus on understanding the impact of neurotechnologies (e.g. spinal cord stimulation, vagal nerve stimulation, and other central and peripheral nerve stimulation) on pain, learning and mental health disorders.. Dr. Lerman is a founding board member of the American Interventional Headache Society, faculty and founding member of the Regenerative Medicine special interest group within the American Society of Regional Anesthesiology and Pain Medicine, and faculty member for the World Academy of Pain Medicine Ultrasonography. Alaa Abd-Elsayed Medical Director, UW Pain Clinic, Division Chief, Chronic Pain Medicine, University of Wisconsin-Madison, Madison, Wisconsin. Dr. Alaa Abd-Elsayed joined the faculty of the Anesthesiology Department at the University of Wisconsin in 2014 to provide Chronic Pain Medicine Services as part of the Interventional Pain Program. He received his medical training at Assiut University Medical School in Egypt, completed a master's degree in Public Health, research fellowship at Cleveland Clinic, and residency in anesthesiology and pain management fellowship at University of Cincinnati. As part of the Interventional Pain Program, Dr. Abd-Elsayed evaluates patients at the Pain Clinic, and when an interventional pain treatment is appropriate, performs procedures at the Madison Surgery Center. Over the course of his career, he has received numerous research grants, published more than 70 peer-reviewed manuscripts and authored several editorials and book chapters. He has presented at more than 60 international and national conferences and has earned more than 15 awards at the state and national levels. In addition, he has served as a reviewer for more than 20 journals and as an editor to several journals.