Mitochondria in Neurological Disorders

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Book
September 2024
Elsevier Science and Technology
ID: 5342332

Mitochondria in Neurological Diseases highlights various therapeutic approaches targeting mitochondria in neurological conditions. Focused on diverse neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, depression, and Amyotrophic lateral sclerosis, topics span basic mitochondrial physiology to mitochondrial dynamics and to the altered states of the nervous system. This book is appropriate for anyone interested in learning more about the physiological and pathophysiological functions of mitochondria in the nervous system.

1. Mitochondria in functions of nervous system
2. Mitochondrial calcium homeostasis in synaptic functions
3. Mitochondrial regulation of neuronal plasticity
4. Communication between mitochondria and other organelles
5. Axoplasmic mitochondrial transport: From Molecules to Mechanisms
6. Yeast as a model for studying human neurodegenerative disorders
7. Sex differences in mitochondrial metabolism
8. Mitochondrial oxidative stress and neurodegeneration
9. Mitochondrial metabolism in neurological disorders
10. Altered mitochondrial signalling in neurodegenerative conditions
11. Mitochondrial DNA, base excision repair and neurodegeneration
12. microRNAs regulating mitochondrial functions in brain
13. Mitochondrial Chaperones in Neurodegenerative Disorders
14. Proteomic profiling of mitochondria in neurodegenerative conditions
15. Association of mitochondrial genetic variants with neurological disorders
16. Mitochondrial dynamics in diseases of nervous system
17. Mitochondrial thiol dioxygenases in diseases of the nervous system
18. Mitophagy in Neurodegenerative Diseases
19. Mitochondria and neuroinflammation
20. Mitochondrial functions in Alzheimer's Disease
21. Mitochondria in Amyotrophic lateral sclerosis
22. Pathways involved in mitochondrial dysfunctions in Huntington's Disease
23. Mitochondrial cascades in Parkinson's Disease
24. Mitochondrial dysfunctions in Psychiatric Disorders
25. Mitochondria in Brain Injury
26. Mitochondrial epigenetics in neurodegeneration
27. Transmitochondrial Cybrids: A cellular model to study mutant mitochondria
28. Targeting mitochondria in neurodegenerative disorders
29. Mitochondrial modulators in neuroprotection
30. Polyphenols and mitochondria in neurodegneration
31. Transplantation of mitochondria in neurodegenerative disorders

Authors

Rajat Sandhir Postgraduate Institute of Medical Education and Research, Chandigarh, India. Dr. Sandhir obtained his M.Sc and Ph.D. degree in Biochemistry from the Postgraduate Institute of Medical Education and Research, Chandigarh. He has been with the Panjab University, Chandigarh for more than 20 years. His research interests are to understand the biochemical and molecular mechanisms involved in development of neurodegenerative conditions like metabolic encephalopathies,?dementia's and?brain injury with a particular interest to understand role of oxidative stress, mitochondria and alterations in Blood-Brain-Barrier. In addition, his interest is also to identify neuroprotective strategies that could ameliorate neurodegenerative conditions. His recent work focuses on mitochondrial dysfunctions in various neurological conditions and to identify various mitochondrial modulators that may be beneficial in protecting nervous system He has over 175 papers to his credit and has mentored over two-dozen Ph.D. students. He has an h-index of 40 and i10 index of 97.

Table of Contents

Authors

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