Translational Autoimmunity: Etiology of Autoimmune Diseases is the first volume of the Translational Immunology book series. To attain its purpose as a detailed translational step to tackle autoimmunity, this volume sufficiently addresses basic questions on how the immune system is designed to distinguish self from nonself. It discusses the known mechanisms that lead to the maintenance of self-tolerance, presents potential triggers and malfunctions that impede normal immune processes, and demonstrates how the immune system induces an autoreactive state that results in the recognition of self-antigens seen in autoimmune conditions.
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Table of Contents
1. Introduction on translational autoimmunity: From bench to bedside
2. Autophagy in autoimmunity
3. Immunometabolism and autoimmunity
4. T cell recognition of neo-epitopes in autoimmunity
5. Role of Th1 and Th2 in autoimmunity
6. Role of Th17 cell in tissue inflammation and organ-specific autoimmunity
7. Peptide editing and its modulation in CD4+ T cell immune tolerance
8. Innate lymphoid cells (ILCs) in the immunopathogenesis of autoimmune diseases
9. Autoimmune diseases and the role of toll-like receptor-7 and -9 signaling cascades
10. Association between type III interferons and systemic autoimmune diseases
11. Regulation of immunological tolerance by NF-kB
12. Micro RNA, circular RNA, neutrophils and myeloperoxydases in autoimmune diseases
13. Human leukocyte antigen and autoimmunity
14. HLA-G-mediated immunological tolerance and autoimmunity
15. The immune system and the microbiota: the two sides of mucosal tolerance
16. Role of free radicals in autoimmune disorders
17. Immunological tolerance and autoimmunity
18. Construction of bioscore for sprouting of self-tolerance failure: From analysis of silicosis cases
