Current Progress in iPSC Disease Modeling, Volume Fourteen in the Advances in Stem Cell Biology series, is a timely and expansive collection of information and new discoveries in the field. This new volume addresses advances in research on how induced pluripotent stem cells are used for the creation of new tissues and organs. The creation of iPSC technology allowed the development of disease-specific human pluripotent stem cells. These cells allow researchers to study questions once impossible for some human diseases. This volume addresses iPSCs for vascular tissue engineering, bioprinting, derived lung organoids for pulmonary disorders, skeletal muscle engineering, human kidney organoids, and more.
It is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation, and is contributed by world-renowned authors in the field.
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Table of Contents
1. Human Induced Pluripotent Stem Cell Modeling of Neurofibromatosis Type 1 2. Use of Inducible Pluripotent Stem Cells (iPSCs) to Model inflammatory Neurodegeneration and Repair in Multiple Sclerosis 3. iPSCs for Modeling Chronic Mountain Sickness 4. iPSCs for Modeling Noonan Syndrome, Noonan Syndrome with Multiple Lentigines, and Costello Syndrome 5. Modeling Mitochondrial Encephalopathy Due to Melas/Leigh Overlap Syndrome Using Induced Pluripotent Stem Cells 6. How iPSCs Changed the Research Status of Polycystic Ovary Syndrome 7. Modeling Inherited Retinal Dystrophies using Induced Pluripotent Stem Cells 8. Modeling Hereditary Spastic Paraplegias using Induced Pluripotent Stem Cells 9. Smith-Magenis Syndrome: From genetics to clinical presentation, disease pathogenesis and model systems 10. iPSCs for Modeling of Cardiac Arrhythmias 11. Modelling heritable kidney disease using human iPSC-derived kidney organoids
Authors
Alexander Birbrair Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, BrazilDepartment of Radiology, Columbia University Medical Center, Medical Center, USA. Dr. Alexander Birbrair received his bachelor's biomedical degree from Santa Cruz State University in Brazil. He completed his PhD in Neuroscience, in the field of stem cell biology, at the Wake Forest School of Medicine under the mentorship of Osvaldo Delbono. Then, he joined as a postdoc in stem cell biology at Paul Frenette's laboratory at Albert Einstein School of Medicine in New York. In 2016, he was appointed faculty at Federal University of Minas Gerais in Brazil, where he started his own lab. His laboratory is interested in understanding how the cellular components of different tissues function and control disease progression. His group explores the roles of specific cell populations in the tissue microenvironment by using state-of-the-art techniques. His research is funded by the Serrapilheira Institute, CNPq, CAPES, and FAPEMIG. In 2018, Alexander was elected affiliate member of the Brazilian Academy of Sciences (ABC), and, in 2019, he was elected member of the Global Young Academy (GYA), and in 2021, he was elected affiliate member of The World Academy of Sciences (TWAS). He is the Founding Editor and Editor-in-Chief of Current Tissue Microenvironment Reports, and Associate Editor of Molecular Biotechnology. Alexander also serves in the editorial board of several other international journals: Stem Cell Reviews and Reports, Stem Cell Research, Stem Cells and Development, and Histology and Histopathology.
