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Short Bowel Syndrome Market Insight, Epidemiology and Market Forecast - 2032

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    Report

  • 132 Pages
  • January 2024
  • Region: Global
  • DelveInsight
  • ID: 5345914

Key Highlights

  • The total market size of short bowel syndrome in the 7MM was approximately USD 2,200 million in 2022, which is expected to grow during the forecast period 2023-2032.
  • Due to diminished absorptive capacity from the reduced intestinal length, conventional diet does not always adequately provide nutrition for short bowel syndrome patients. Consequently, many patients rely on total parenteral nutrition.
  • The primary objectives in treating both adults and children with parenteral support involve alleviating the impact on their quality of life and minimizing complications associated with the condition.
  • Glucagon-like peptide-2 (GLP-2) agonists and, more recently, glucagon-like peptide-1 (GLP-1) agonists have been used to increase nutrient and fluid absorption and partially or wholly ameliorate the use of parenteral nutrition in short bowel syndrome patients.
  • Next-generation GLP-2 agonists therapies, apraglutide and glepaglutide, have demonstrated clinically meaningful and durable responses in patients with short bowel syndrome, in STARS Nutrition and EASE-1 clinical studies, respectively.
  • The total diagnosed prevalent cases of short bowel syndrome in the US was around 1,4000 in 2022.
This “Short Bowel Syndrome - Market Insights, Epidemiology, and Market Forecast - 2032” report delivers an in-depth understanding of Short Bowel Syndrome, historical and forecasted epidemiology as well as Short Bowel Syndrome market trends in the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan.

The Short Bowel Syndrome market report provides current treatment practices, emerging drugs, market share of individual therapies, and current and forecasted the 7MM Short Bowel Syndrome market size from 2019 to 2032. The report also covers current Short Bowel Syndrome treatment practices/algorithms and unmet medical needs to curate the best opportunities and assess the market's potential.

Geography Covered

  • The United States
  • EU4 (Germany, France, Italy, and Spain) and the United Kingdom
  • Japan
Study Period: 2019-2032

Short Bowel Syndrome Disease Understanding and Treatment Algorithm

Short Bowel Syndrome Overview

Short bowel syndrome is a complex disease that occurs due to the physical loss or the loss of function of a portion of the small and/or large intestine. Consequently, individuals with short bowel syndrome often have a reduced ability to absorb nutrients such as fats, carbohydrates (sugars) vitamins, minerals, trace elements and fluids (malabsorption). The specific symptoms and severity of short bowel syndrome vary from one person to another. Diarrhea is common, often severe and can cause dehydration, which can even be life threatening. Short bowel syndrome can lead to malnutrition, unintended weight loss and additional symptoms may be due to the loss of essential vitamins and minerals. There is no cure, but the disorder usually can be treated effectively. However, in some cases, short bowel syndrome can lead to severe, disabling and life-threatening complications.

Short Bowel Syndrome Diagnosis

A diagnosis of short bowel syndrome is made based upon a detailed patient history, a thorough clinical evaluation and a variety of specialized tests including laboratory tests and X-ray studies.

A health care provider diagnoses short bowel syndrome based on a medical and family history, a physical exam, blood tests such as CBC, albumin, creatinine tests, and others. Fecal fat tests is also performed, which can show how well the small intestine is working. Imaging techniques may be used to assess individuals with short bowel syndrome. Such tests include plain abdominal X-rays to detect signs of obstruction or ileus (paralysis of intestinal muscles), computerized tomography (CT) scanning of the abdomen (abdominal CAT scan), magnetic resonance imaging (MRI) of the abdomen or an abdominal ultrasound. Upper GI series, also called a barium swallow, uses X-rays and fluoroscopy to help diagnose problems of the upper GI tract.

Further details related to diagnosis are provided in the report.

Short Bowel Syndrome Treatment

The treatment approach for short bowel syndrome is tailored to individual symptoms and factors such as the extent of small intestine loss, overall health, and patient preferences. A multidisciplinary team, including gastroenterologists, surgeons, dietitians, and other healthcare professionals, collaborates to create a personalized plan. Treatment options encompass total parenteral nutrition (TPN), enteral feeding, dietary adjustments, oral rehydration solutions, medications, and surgery. Intestinal adaption, a process enhancing the remaining small bowel's absorption capabilities, is a key focus, and nutritional management is vital. TPN, though associated with complications, may be required, with advances like recombinant growth hormone and glucagon-like peptide analogs offering alternatives. Medications address symptoms and may include GATTEX, anti-diarrheals, acid reducers, and growth hormones. Surgical interventions range from non-transplant procedures, such as artificially lengthening the intestines, to transplant surgeries, like small bowel transplants, considered in severe cases. The goal is to improve nutrient absorption, minimize reliance on TPN, and enhance overall quality of life for individuals with short bowel syndrome.

Further details related to treatment are provided in the report.

Short Bowel Syndrome Epidemiology

The short bowel syndrome epidemiology chapter in the report provides historical as well as forecasted epidemiology segmented by prevalent cases of home parenteral nutrition (HPN), diagnosed prevalent cases of short bowel syndrome, age-specific cases of short bowel syndrome, gender-specific cases of short bowel syndrome, etiology-specific cases of short bowel syndrome in the 7MM covering the United States, EU4 countries (Germany, France, Italy, and Spain), United Kingdom, and Japan from 2019 to 2032.
  • In the 7MM, the highest prevalent cases of short bowel syndrome were seen in the United States, followed by EU4 and the UK in 2022.
  • Short bowel syndrome is more common in females as compared to males. In the United States, more than 67% of females are diagnosed with short bowel syndrome.
  • In the United States, there were around 29% surgical complications and nearly 24% mesenteric infarction cases cause found in short bowel syndrome in 2022.
  • In EU4 and the UK age-specific cases of short bowel syndrome, the highest number of cases accounting for were observed in adults compared with pedriatic.

Short Bowel Syndrome Drug Chapters

The drug chapter segment of the Short Bowel Syndrome report encloses a detailed analysis of the marketed and the late-stage (Phase III) pipeline drug. The marketed drugs segment encloses GATTEX/REVESTIVE (Takeda). Furthermore, the current key players for the upcoming emerging drugs include VectivBio/Ironwood (apraglutide), Zealand Pharma (glepaglutide), Hanmi Pharmaceuticals (HM15912), and others. The drug chapter also helps understand the short bowel syndrome clinical trial details, expressive pharmacological action, agreements and collaborations, approval and patent details, and the latest news and press releases.

Marketed Drugs

GATTEX/REVESTIVE: Takeda (Shire Pharmaceuticals)

GATTEX/REVESTIVE (teduglutide) is an analog of naturally occurring human GLP-2, a peptide secreted by L-cells of the distal intestine. GLP-2 is known to increase intestinal and portal blood flow and inhibit gastric acid secretion. Teduglutide binds to the glucagon-like peptide-2 receptors located in intestinal subpopulations of enteroendocrine cells, subepithelial myofibroblasts and enteric neurons of the submucosal and myenteric plexus. Activation of these receptors results in the local release of multiple mediators including insulin-like growth factor (IGF)-1, nitric oxide and keratinocyte growth factor (KGF). The active ingredient in GATTEX for injection is teduglutide, which is a 33 amino acid glucagon-like peptide-2 (GLP-2) analog manufactured using a strain of Escherichia coli modified by recombinant DNA technology. In December 2012, the US FDA approved GATTEX to treat adults with short bowel syndrome who are dependent on parenteral support. In May 2019, the US FDA approved GATTEX for children 1 year of age and older with short bowel syndrome. In June 2021, Japanese Ministry of Health, Labour and Welfare (MHLW) approved REVESTIVE as a treatment for short bowel syndrome.

In April 2023, the Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion recommending a change to the terms of the marketing authorization for REVESTIVE. The CHMP adopted an extension to the existing indication as teduglutide for the treatment of patients 4 months corrected gestational age and above with short bowel syndrome.

Note: Detailed list will be provided in the final report.

Emerging Drugs

Apraglutide: VectivBio/Ironwood

Apraglutide is a next-generation, long-acting synthetic GLP-2 analog being developed for a range of rare GI diseases and is currently being evaluated as a potential once-weekly treatment for patients with short bowel syndrome with intestinal failure. Apraglutide has completed Phase II studies and is currently being evaluated in a pivotal Phase III clinical trial. The global Phase III clinical, called STARS, is evaluating the safety and efficacy of apraglutide in adults with short bowel syndrome.

In addition to the STARS trial, the company is conducting the STARS Nutrition and Open-Label Extension studies to evaluate the efficacy, safety, and tolerability of apraglutide in short bowel syndrome with intestinal failure further and to support potential submissions of marketing applications for apraglutide in the United States, European Union, and Japan. In October 2023, the company presented positive final data from the STARS Nutrition Phase II study of apraglutide in patients with short bowel syndrome with intestinal failure and colon-in-continuity (CIC).

Glepaglutide: Zealand Pharma

Glepaglutide is a long-acting GLP-2 analog that is stable in aqueous solution. Zealand is developing glepaglutide as a ready-to-use, fixed-dose product for subcutaneous delivery via auto-injector to treat short bowel syndrome. The Phase III program, named EASE, includes four clinical trials evaluating the potential for glepaglutide to reduce or eliminate the need for parenteral support in short bowel syndrome with intestinal failure.

In the fourth quarter of 2023, Zealand expects to submit an NDA to the US FDA for glepaglutide for the treatment of short bowel syndrome with intestinal failure. The submission will be based on EASE-1 and interim results from EASE-2, EASE-3, and EASE-4.

Drug Class Insights

The landscape of short bowel syndrome drug development is evolving with GLP-2 agonists such as GATTEX, glepaglutide, and apraglutide.

GLP-2 agonists: GLP-2 agonists are a class of therapeutic agents that mimic the action of GLP-2, a hormone involved in the regulation of the gastrointestinal tract. GLP-2 is known for its intestinotrophic effects, meaning it promotes growth and maintenance of the small intestine. GLP-2 agonists are primarily used in the treatment of conditions such as short bowel syndrome where there is a reduced length or function of the small intestine, leading to challenges in nutrient absorption. GATTEX, an approved GLP-2 agonist, demonstrates higher effectiveness in reducing TPN dependence for short bowel syndrome patients with stomas compared to those with catheters, holding a larger market share among stoma patients. Despite efficacy, GATTEX requires daily subcutaneous injections due to its short half-life, and its lyophilized powder formulation involves a complex reconstitution process. Glepaglutide and apraglutide are emerging therapies showing promise in addressing GATTEX limitations, potentially offering improved efficacy, longer duration of action, and easier administration.

Note: Detailed insights will be provided in the final report.

Short Bowel Syndrome Market Outlook

The treatment of short bowel syndrome is individualized, taking into account the severity and specific symptoms of each patient. TPN, involving intravenous fluids with nutrient therapy, may be necessary to address potential nutrient deficiencies. While TPN can be transitioned to home care, prolonged use poses risks such as infections, blood clotting, and potential harm to the liver and kidneys. Patients often use additional medications, such as anti-diarrheals, to alleviate short bowel syndrome symptoms. Chronic intestinal failure (CIF) in short bowel syndrome is marked by the inability to achieve optimal intestinal adaptation for maintaining oral/enteral autonomy.

Surgical management is a crucial strategy for short bowel syndrome patients. Those on parenteral nutrition with rapid transit may benefit from interventions like reversing intestinal segments or interposing segments of the colon into the small bowel. Individuals with less than 60 cm of small bowel and complications from parenteral nutrition may be considered for intestinal transplantation. For patients with dilated bowel due to obstruction, treatments like intestinal tapering or strictureplasty are options based on the length of the remaining bowel. Tapering with lengthening may be considered for remnants less than 90 cm in adults or less than 30 cm in children.

The management of short bowel syndrome involves a multidisciplinary team, including gastroenterologists and nutrition specialists, due to the complexity and varied clinical implications of the condition.
  • The total market size in the US for short bowel syndrome was estimated to be nearly USD 1,900 in 2022, which is expected to increase due to the launch of emerging therapies and label expansion of current therapies.
  • GATTEX (teduglutide), the key drug in the therapeutic area, received FDA and EMA approval in 2012 for adult short bowel syndrome patients dependent on PN. Later approvals extended its use to children and infants. Patent expiry for GATTEX is in 2023, with potential generic introductions anticipated.
  • GLP-1, released in response to elevated luminal glucose and fatty acids, originates from ileum L-cells. Binding to GLP-1 receptors in target tissues, such as stomach and small intestine smooth muscle, it triggers the ileal brake, slowing gastric emptying and small bowel motility. In a pilot study with five Short Bowel Syndrome patients, the GLP-1 agonist exenatide reduced diarrhea in all subjects, leading to the discontinuation of parenteral nutrition in 60% of cases.
  • Companies are actively working on developing therapies for short bowel syndrome, with drugs like glepaglutide, apraglutide, and HM15912 undergoing assessment for potential market availability in the future. Glepaglutide, is expected to capture a market share of around 14% by 2032, in the 7MM.

Short Bowel Syndrome Drugs Uptake

This section focuses on the uptake rate of potential drugs expected to be launched in the market during 2019-2032, which depends on the competitive landscape, safety, efficacy data, and order of entry. It is important to understand that the key players evaluating their novel therapies in the pivotal and confirmatory trials should remain vigilant when selecting appropriate comparators to stand the greatest chance of a positive opinion from regulatory bodies, leading to approval, smooth launch, and rapid uptake.

Further detailed analysis of emerging therapies drug uptake in the report.

Short Bowel Syndrome Activities

The report provides insights into different therapeutic candidates in Phase III and Phase II stages. It also analyzes key players involved in developing targeted therapeutics.

Pipeline Development Activities

The report covers information on collaborations, acquisitions and mergers, licensing, and patent details for short bowel syndrome emerging therapies.

KOL Views

To keep up with the real-world scenario in current and emerging market trends, we take opinions from Key Industry leaders working in the domain through primary research to fill the data gaps and validate our secondary research. Industry experts contacted for insights on the evolving treatment landscape, patient reliance on conventional therapies, patient's therapy switching acceptability, and drug uptake along with challenges related to accessibility, including Medical/scientific writers, Neonatal and Paediatric Surgeons, Consultant Gastroenterologists, and others.

This analysts connected with 20+ KOLs to gather insights; however, interviews were conducted with 10+ KOLs in the 7MM. Centers such as American Gastroenterological Association,USA, Lennard Jones Intestinal Failure Unit, UK, Gastroenterology and Endoscopy Unit, University of the Study of Milan, Italy, etc., were contacted. Their opinion helps understand and validate current and emerging therapy treatment patterns or short bowel syndrome market trends.

Qualitative Analysis

The publisher performs qualitative and market Intelligence analysis using various approaches, such as SWOT analysis and Analyst views. In the SWOT analysis, strengths, weaknesses, opportunities, and threats in terms of disease diagnosis, patient awareness, patient burden, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided. These pointers are based on the Analyst's discretion and assessment of the patient burden, cost analysis, and existing and evolving treatment landscape.

Market Access and Reimbursement

Market Access refers to the ability of all patients to have access to a given product quickly, conveniently, and affordably. Reimbursement is the negotiation of a price between the manufacturer and payer that allows the manufacturer access to that market. It is provided to reduce the high costs and make essential drugs affordable.

OnePath product support is available to eligible patients prescribed a Takeda treatment for alpha-1 antitrypsin deficiency (Alpha-1), hereditary angioedema (HAE), Hunter syndrome (MPS II), short bowel syndrome (SBS), and type 1 Gaucher disease. The program can cover up to 100% of the patient's out-of-pocket copay costs if patients are eligible.

Scope of the Report

  • The report covers a segment of key events, an executive summary, and a descriptive overview of Short Bowel Syndrome, explaining its causes, signs and symptoms, pathogenesis, and currently available therapies.
  • Comprehensive insight has been provided into the epidemiology segments and forecasts, the future growth potential of diagnosis rate, disease progression, and treatment guidelines.
  • Additionally, an all-inclusive account of the current and emerging therapies and the elaborative profiles of late-stage and prominent therapies will impact the current treatment landscape.
  • A detailed review of the Short Bowel Syndrome market, historical and forecasted market size, market share by therapies, detailed assumptions, and rationale behind our approach is included in the report, covering the 7MM drug outreach.
  • The report provides an edge while developing business strategies by understanding trends through SWOT analysis and expert insights/KOL views, patient journey, and treatment preferences that help in shaping and driving the 7MM Short Bowel Syndrome market.

Short Bowel Syndrome Report Insights

  • Patient Population
  • Therapeutic Approaches
  • Short Bowel Syndrome Pipeline Analysis
  • Short Bowel Syndrome Market Size and Trends
  • Existing and Future Market Opportunity

Report Key Strengths

  • Ten Years Forecast
  • The 7MM Coverage
  • Short Bowel Syndrome Epidemiology Segmentation
  • Key Cross Competition
  • Drugs Uptake and Key Market Forecast Assumptions

Short Bowel Syndrome Report Assessment

  • Current Treatment Practices
  • Unmet Needs
  • Pipeline Product Profiles
  • Market Attractiveness
  • Qualitative Analysis (SWOT)

FAQs

  • What is the historical and forecasted Short Bowel Syndrome patient pool in the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan?
  • What was the Short Bowel Syndrome total market size, the market size by therapies, market share (%) distribution in 2019, and what would it look like by 2032? What are the contributing factors for this growth?
  • Which therapy is going to be the largest contributor by 2032?
  • What will be the impact of GATTEX's expected patent expiry?
  • How will GATTEX compete with apraglutide in the market for short bowel syndrome?
  • How does HM15912 differentiate itself from existing GLP-2 agonists like GATTEX, and what potential advantages or innovations does it bring to the landscape of Short Bowel Syndrome treatments, considering factors such as dosing frequency, administration method, and clinical efficacy?
  • What are the pricing variations among different geographies for approved and off-label therapies?
  • How would the market drivers, barriers, and future opportunities affect the market dynamics and subsequent analysis of the associated trends?
  • What are the recent novel therapies, targets, mechanisms of action, and technologies developed to overcome the limitations of existing therapies?
  • Patient acceptability in terms of preferred treatment options as per real-world scenarios?
  • What are the country-specific accessibility issues of expensive, recently approved therapies?

Reasons to Buy

  • The report will help in developing business strategies by understanding the latest trends and changing treatment dynamics driving the Short Bowel Syndrome Market.
  • Insights on patient burden/disease prevalence, evolution in diagnosis, and factors contributing to the change in the epidemiology of the disease during the forecast years.
  • Understand the existing market opportunities in varying geographies and the growth potential over the coming years.
  • Distribution of historical and current patient share based on real-world prescription data along with reported sales of approved products in the US, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan.
  • Identifying strong upcoming players in the market will help devise strategies to help get ahead of competitors.
  • Highlights of access and reimbursement policies of approved therapies, barriers to accessibility of expensive off-label therapies, and patient assistance programs.
  • To understand Key Opinion Leaders' perspectives around the accessibility, acceptability, and compliance-related challenges of existing treatment to overcome barriers in the future.
  • Detailed insights on the unmet needs of the existing market so that the upcoming players can strengthen their development and launch strategy.

Table of Contents

1. Key Insights2. Report Introduction
3. Short Bowel Syndrome (SBS) Market Overview at a Glance
3.1. Market Share (%) Distribution of Short bowel syndrome in 2020 in the 7MM
3.2. Market Share (%) Distribution of Short bowel syndrome in 2034 in the 7MM
4. Executive Summary5. Key Events6. Epidemiology and Market Methodology
7. Disease Background and Overview
7.1. Introduction
7.2. Causes
7.3. Symptoms
7.4. Pathophysiology
7.5. Consequences of SBS
7.6. Complications of SBS
7.6.1. Catheter-Related Complications
7.6.2. Small Intestine Bacterial Overgrowth (SIBO)
7.6.3. D-Lactic Acidosis
7.6.4. Intestinal Failure-Associated Liver Disease (IFALD)
7.6.5. Other Complications
7.7. Diagnosis
7.7.1. Differential Diagnosis
8. Treatment
8.1. Conventional Therapy
8.2. Nonconventional Therapy
8.3. Parenteral Nutrition
8.4. Enterological Treatment
8.5. Surgical Management
9. Epidemiology and Patient Population
9.1. Key Findings
9.2. Prevalence of Home Parenteral Nutrition (HPN) Use in the 7MM
9.2. Prevalence of Home Parenteral Nutrition (HPN) Use in the 7MM
9.3. Diagnosed Prevalence of SBS in the 7MM
9.4. Assumptions and Rational
9.5. The United States
9.5.1. Total Diagnosed Prevalent Cases of SBS in the United States
9.5.1. Gender-Specific Cases of SBS in the United States
9.2. Prevalence of Home Parenteral Nutrition (HPN) Use in the 7MM
9.3. Diagnosed Prevalence of SBS in the 7MM
9.6. EU4 and the UK
9.6.1. Total Diagnosed Prevalent Cases of SBS in EU4 and the UK
9.6.2. Gender-Specific Cases of SBS in EU4 and the UK
9.6.3. Age-Specific Cases of SBS in EU4 and the UK
9.6.4. Etiology-Specific Cases of SBS in EU4 and the UK
9.7. Japan
9.7.1. Total Diagnosed Prevalent Cases of SBS in Japan
9.7.2. Gender-Specific Cases of SBS in Japan
9.7.3. Age-Specific Cases of SBS in Japan
9.7.4. Etiology-Specific Cases of SBS in Japan
10. Patient Journey
11. Marketed Product
11.1. GATTEX/REVESTIVE (teduglutide): Takeda (Shire Pharmaceuticals)
11.1.1. Product Description
11.1.2. Regulatory Milestones
11.1.3. Other Developmental Activities
11.1.4. Safety and Efficacy
11.1.5. Product Profile
12. Emerging Drugs
12.1. Key Competition
12.2. Apraglutide: VectivBio/Ironwood
12.2.1. Product Description
12.2.2. Other Developmental Activities
12.2.3. Clinical Development
12.2.3.1. Clinical Trials Information
12.2.4. Safety and Efficacy
12.3. Glepaglutide: Zealand Pharma
12.3.1. Product Description
12.3.2. Other Developmental Activities
12.3.3. Clinical Development
12.3.3.1. Clinical Trials Information
12.3.4. Safety and Efficacy
12.4. HM15912: Hanmi Pharmaceutical
12.4.1. Product Description
12.4.2. Other Developmental Activity
12.4.3. Clinical Development
12.4.3.1. Clinical Trials Description
13. Short Bowel Syndrome: 7 Major Market Analysis
13.1. Key Findings
13.2. Market Outlook
13.3. Conjoint Analysis
13.5. Key Market Forecast Assumptions
13.6. Total Market Size of SBS in the 7MM
13.7. Market Size of SBS by Therapies in the 7MM
13.8. United States Market Size
13.8.1. Total Market Size of SBS in the United States
13.8.2. Market Size of SBS by Therapies in the United States
13.9. EU4 and the UK Market Size
13.9.1. Total Market Size of SBS in EU4 and the UK
13.9.2. Market Size of SBS by Therapies in EU4 and the UK
13.10. Japan Market Size
13.10.1. Total Market Size of SBS in Japan
13.10.2. Market Size of SBS by Therapies in Japan
14. Unmet Needs15. SWOT Analysis16. KOL Views
17. Market Access and Reimbursement
17.1. United States
17.1.1. Centre for Medicare and Medicaid Services (CMS)
17.2. EU4 and the UK
17.2.1. Germany
17.2.2. France
17.2.3. Italy
17.2.4. Spain
17.2.5. United Kingdom
17.3. Japan
17.3.1. MHLW
17.4. Short Bowel Syndrome: Market Access and Reimbursement
17.4.1. Patient Access Programs
17.4.2. HTA Decisions
18. Appendix
18.1. Abbreviations
18.2. Bibliography
18.3. Report Methodology
19. Publisher Capabilities20. Disclaimer21. About the Publisher
List of Tables
Table 1: Summary of SBS Market and Epidemiology (2020-2034)
Table 2: Main Characteristic of the Different Type of SBS According to the Anatomical Criteria
Table 3: Prevalence of Home Parenteral Nutrition Use in the 7MM (2020-2034)
Table 4: Diagnosed Prevalence of SBS in in the 7MM (2020-2034)
Table 5: Total Prevalent Cases of SBS in the United States (2020-2034)
Table 6: Gender-Specific Cases of SBS in the United States (2020-2034)
Table 7: Age-Specific Cases of SBS in the United States (2020-2034)
Table 8: Etiology-Specific Cases of SBS in the United States (2020-2034)
Table 9: Total Diagnosed Prevalent Cases of SBS in EU4 and the UK (2020-2034)
Table 10: Gender-Specific Cases of SBS in EU4 and the UK (2020-2034)
Table 11: Age-Specific Cases of SBS in EU4 and the UK (2020-2034)
Table 12: Etiology-Specific Cases in of SBS in EU4 and the UK (2020-2034)
Table 13: Total Diagnosed Prevalent Cases of SBS in Japan (2020-2034)
Table 14: Gender-Specific Cases of SBS in Japan (2020-2034)
Table 15: Age-Specific Cases of SBS in Japan (2020-2034)
Table 16: Etiology-Specific Cases of SBS in Japan (2020-2034)
Table 17: Comparison of Marketed Drugs for SBS
Table 18: Emerging Drugs Key Cross
Table 19: Apraglutide: Clinical Trial Description, 2024
Table 20: Glepaglutide: Clinical Trial Description, 2024
Table 21: HM15912: Clinical Trial Description, 2024
Table 22: SBS Data Comparison
Table 23: Key Market Forecast Assumption of SBS in the United States
Table 24: Key Market Forecast Assumption of SBS in EU4 and the UK
Table 25: Key Market Forecast Assumption of SBS in Japan
Table 26: Market Size of SBS in the 7MM, USD million (2020-2034)
Table 27: Market Size of SBS by Therapies in the 7MM, USD million (2020-2034)
Table 28: Market Size of SBS in the United States, USD million (2020-2034)
Table 29: Market Size of SBS by Therapies in the United States, USD million (2020-2034)
Table 30: Market Size of SBS in EU4 and the UK, USD million (2020-2034)
Table 31: Market Size of SBS by Therapies in EU4 and the UK, USD million (2020-2034)
Table 32: Total Market Size of SBS in Japan, USD million (2020-2034)
Table 33: Market Size of SBS by Therapies in the Japan, USD million (2020-2034)
List of Figures
Figure 1: Signs and Symptoms of SBS
Figure 2: Consequences of Small Intestine Bacterial Overgrowth (SIBO)
Figure 3: Main Reasons for Occurrence of Intestinal Failure-associated Liver Disease (IFALD) in Children with Short-bowel Syndrome.
Figure 4: Differential Diagnosis of SBS
Figure 5: Prevalence of Home Parenteral Nutrition Use in the 7MM (2020-2034)
Figure 6: Diagnosed Prevalence of SBS in the 7MM (2020-2034)
Figure 7: Total Prevalent Cases of SBS in the United States (2020-2034)
Figure 8: Gender-Specific Cases of SBS in the United States (2020-2034)
Figure 9: Age-Specific Cases of SBS in the United States (2020-2034)
Figure 10: Etiology-Specific Cases of SBS in the United States (2020-2034)
Figure 11: Total Diagnosed Prevalent Cases of SBS in EU4 and the UK (2020-2034)
Figure 12: Gender-Specific Cases of SBS in EU4 and the UK (2020-2034)
Figure 13: Age-Specific Cases of SBS in EU4 and the UK (2020-2034)
Figure 14: Etiology-Specific Cases in of SBS in EU4 and the UK (2020-2034)
Figure 15: Total Diagnosed Prevalent Cases of SBS in Japan (2020-2034)
Figure 16: Gender-Specific Cases of SBS in Japan (2020-2034)
Figure 17: Age-Specific Cases of SBS in Japan (2020-2034)
Figure 18: Etiology-Specific Cases of SBS in Japan (2020-2034)
Figure 19: Market Size of SBS in the 7MM, USD million (2020-2034)
Figure 20: Market Size of SBS by Therapies in the 7MM, USD million (2020-2034)
Figure 21: Market Size of SBS in the United States, USD million (2020-2034)
Figure 22: Market Size of SBS by Therapies in the United States, USD million (2020-2034)
Figure 23: Market Size of SBS in EU4 and the UK, USD million (2020-2034)
Figure 24: Market Size of SBS by Therapies in EU4 and the UK, USD million (2020-2034)
Figure 25: Total Market Size of SBS in Japan, USD million (2020-2034)
Figure 26: Market Size of SBS by Therapies in Japan, USD million (2020-2034)
Figure 27: Health Technology Assessment
Figure 28: Reimbursement Process in Germany
Figure 29: Reimbursement Process in France
Figure 30: Reimbursement Process in Italy
Figure 31: Reimbursement Process in Spain
Figure 32: Reimbursement Process in the United Kingdom
Figure 33: Reimbursement Process in Japan

Companies Mentioned (Partial List)

A selection of companies mentioned in this report includes, but is not limited to:

  • VectivBio
  • Ironwood
  • Zealand Pharma
  • Hanmi Pharmaceutical