Pseudomonas aeruginosa is known as a persistent bacterial pathogen. Antibiotics are currently the most common bacterial treatment for related infections but cases of microbial resistance are on the rise. Toxin-Antitoxin Systems in Pseudomonas aeruginosa describes one of the most important antimicrobial targets in the bacterium species.
The contributors have compiled comprehensive information on the subject. The reference initially acquaints the reader with key topics about P. aeruginosa infection including virulence factors, pathogenicity, epidemiology, laboratory diagnosis and antibiotic resistance.
This is followed by detailed chapters on toxin-antitoxin systems which explain their role in the bacterial pathogenesis with reference to P. aeruginosa. The comprehensive information on the subject makes this an ideal reference for newcomers to the field of bacteriology and target discovery. Students of medical microbiology and medical professionals who are interested in the finer details of P. aeruginosa pathogenicity will also be equipped with sufficient information to join the discussion on this topic with fellow researchers.
The contributors have compiled comprehensive information on the subject. The reference initially acquaints the reader with key topics about P. aeruginosa infection including virulence factors, pathogenicity, epidemiology, laboratory diagnosis and antibiotic resistance.
This is followed by detailed chapters on toxin-antitoxin systems which explain their role in the bacterial pathogenesis with reference to P. aeruginosa. The comprehensive information on the subject makes this an ideal reference for newcomers to the field of bacteriology and target discovery. Students of medical microbiology and medical professionals who are interested in the finer details of P. aeruginosa pathogenicity will also be equipped with sufficient information to join the discussion on this topic with fellow researchers.
Table of Contents
Chapter 1 an Overview of Pseudomonas Aeruginosa- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 2 History and Etymology
M. Mahmoudi, S. Ghafourian, N. Sadeghifard and B. Badakhsh
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 3 Virulence Factors of P. Aeruginosa and Their Role In
- Pathogenicity
2. Adhesions
2.1. Type Iv Pili (Tfp)
2.2. Lectins
2.3. Alginate
2.4. Flagella
3. Pigments
3.1. Pyoverdine
3.2. Pyocyanin
3.3. Pyorubin
3.4. Pyomelanin
3.5. Other Pigments
4. P. Aeruginosa Forms in Nature (Planktonic and Biofilm)
5. Toxins
5.1. Exotoxin a
5.2. Exotoxin S
5.3. Leukocidin (Cytotoxin)
5.4. Enterotoxin
6. Enzymes
6.1. Phospholipase C (Plc)
6.2. Rhamnolipid
6.3. Proteases
6.3.1. Lasb
6.3.2. Lasa
6.3.3. Alkaline Protease
6.3.4. Protease Iv
- Consent for Publication
M. Mahmoudi, S. Ghafourian, A. Maleki and B. Badakhsh
- Conflict of Interest
- Acknowledgements
- References
Chapter 4 Epidemiology
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 5 Pathogenicity
1. Bacteremia
2. Bone and Joint Infections
3. Keratitis
4. Pneumonia
5. Chronic Respiratory Tract Infections
6. Urinary Tract Infection (Uti)
7. Skin and Soft Tissues Infections
8. Ear Infections
9. Endocarditis
10. Central Nervous System (Cns) Infections
11. Enteric Infection
12. Mastitis
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 6 Laboratory Diagnosis
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 7 Antibiotic Resistance and Treatment
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 8 Toxin-Antitoxin Systems
1. Classification of the Ta Systems
1.1. Type I Ta System
1.2. Type Ii Ta System
1.3. Type Iii Ta System
1.4. Type Iv Ta System
1.5. Type V Ta System
1.6. Type Vi Ta System
M. Mahmoudi, S. Ghafourian, N. Sadeghifard and B. Badaksh
M. Mahmoudi, S. Ghafourian, B. Badakhsh, H. Kazemian and A. Maleki
M. Mahmoudi, S. Ghafourian, H. Kazemian and B. Badaksh
M. Mahmoudi, S. Ghafourian, H. Kazemian and B. Badakhsh
M. Mahmoudi, S. Ghafourian and A. Maleki
2. Ta System Functions
2.1. Antibiotic Resistance
2.2. Biofilm Formation
2.3. Persister Cell Formation
2.4. Genomic Junk
2.5. Programmed Cell Death (Pcd)
2.6. Post Segregational Killing (Psk)
2.7. Plasmid Maintenance
2.8. Antiphage Activity
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 9 Acquaintance with the Known Toxin-Antitoxin Systems in P.
- Aeruginosa
1. Higba Ta System
2. Hicab Ta System
3. Parde Ta System
4. Relbe Ta System
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
- Subject Index
Author
- Mina Mahmoudi
- Sobhan Ghafourian
- Behzad Badakhsh
