The development of a vector for the delivery of therapeutic drugs in a controlled and targeted fashion is still a major challenge in the treatment of many diseases. The conventional application of drugs may lead to many limitations including poor distribution, limited effectiveness, lack of selectivity and dose dependent toxicity. An efficient drug delivery system can address these problems. Recent nanotechnology advancements in the biomedical field have the potential to meet these challenges in developing drug delivery systems. Nanomaterials are changing the biomedical platform in terms of disease diagnosis, treatment and prevention. Nanomaterials aided drug delivery provides an advantage by enhancing aqueous solubility that leads to improved bioavailability, increased resistance time in the body, decreased side effects by targeting drugs to the specific location, reduced dose dependent toxicity and protection of drugs from early release.
In this two-part book, the contributors have compiled reports of recent studies illustrating the promising nanomaterials that can work as drug carriers which can navigate conventional physiological barriers. A detailed account of several types of nanomaterials including polymeric nanoparticles, liposomes, dendrimers, micelles, carbon nanomaterials, magnetic nanoparticles, solid lipid-based nanoparticles, silica nanomaterials and hydrogels for drug delivery is provided in separate chapters. The contributors also present a discussion on clinical aspects of ongoing research with insights towards future prospects of specific nanotechnologies.
Part II covers the following topics:
The book set is an informative resource for scholars who seek updates in nanomedicine with reference to nanomaterials used in drug delivery systems.
In this two-part book, the contributors have compiled reports of recent studies illustrating the promising nanomaterials that can work as drug carriers which can navigate conventional physiological barriers. A detailed account of several types of nanomaterials including polymeric nanoparticles, liposomes, dendrimers, micelles, carbon nanomaterials, magnetic nanoparticles, solid lipid-based nanoparticles, silica nanomaterials and hydrogels for drug delivery is provided in separate chapters. The contributors also present a discussion on clinical aspects of ongoing research with insights towards future prospects of specific nanotechnologies.
Part II covers the following topics:
- Solid lipid nanoparticles and nanostructured lipid carriers
- Silica based nanomaterials
- Hydrogels
- Metallic nanoparticles
- Computational and experimental binding interactions of drug and β-cyclodextrin
- Clinical milestones in nanotherapeutics
- Drug delivery systems based on poly (lactide-co-glycolide) and its copolymers
The book set is an informative resource for scholars who seek updates in nanomedicine with reference to nanomaterials used in drug delivery systems.
Table of Contents
Chapter 1 Solid Lipid Nanoparticles and Nanostructured Lipid- Carriers for Drug Delivery Applications
- Gabriel Silva Borges, Mariana Silva Oliveira, Délia Chaves Moreira Dos Santos, Lucas
- Antônio Miranda Ferreira and Guilherme Carneiro
- Introduction
- Background
- Composition of Sln and Nlc
- Lipids
- Surfactants
- Other Components
- Methods for Sln and Nlc Production
- Hot or Cold Homogenization Technique
- High Pressure Homogenization (Hph)
- Ultrasonication
- O/W Microemulsion
- Emulsification-Solvent Evaporation
- Solvent Injection Method
- Multiple Emulsion
- Membrane Contactor Method
- Super Critical Fluid Technique
- Drug Distribution in Lipid Nanocarriers
- Strategies for Improving Encapsulation of Drugs in Lipid Nanoparticles
- Physicochemical Characterization
- Particle Size
- Dynamic Light Scattering
- Laser Diffraction
- Scanning Ion Occlusion Spectroscopy
- Zeta Potential
- Crystallinity and Polymorphism
- Differential Scanning Calorimetry
- X-Ray Diffraction
- Particle Shape and Morphology
- Drug Encapsulation Efficiency and Drug Loading
- Soluble in Aqueous Medium
- Precipitated
- Total Drug Concentration
- Common Problems in Sln and Nlc
- Gelation
- Supercooled Melts
- Coexistence of Nanostructures
- Main Applications of Sln and Nlc in Pharmaceutics
- Administration Routes
- Dermal Route
- Oral Route
- Pulmonary Route
- Intravenous Administration
- Intranasal Delivery
- Ophthalmic Delivery
- Important Applications of Sln and Nlc
- Cancer
- Brain Delivery
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 2 Silica Based Nanomaterial for Drug Delivery
- Charu Bharti, Md. Sabir Alam, Md. Noushad Javed, Muhammed Khalid Saifullah,
- Faisal A. Almalki and Romila Manchanda
- Introduction
- Chemistry of Mesoporous Silica Nanoparticles
- Characteristics of Msns
- Characterization Techniques Used for Msns
- Ft-Ir Spectra
- Electron Microscopy
- Methods of Preparation of Msns
- Stober Process
- Evaporation Induced Assembly Synthesis
- Combustion Synthesis Process
- Aerosol Decomposition Synthesis
- Chemical Vapour Deposition
- Photothermal Synthesis
- Inert Gas Condensation
- Surface Functionalization of Silica Nanoparticles by Various
- Methods
- Co-Condensation Method
- Post-Synthetic Grafting
- Biocompatibility and Bio-Distribution
- Impact of Size and Shape of the Particle
- Impact of Surface Properties
- Applications of Msns
- Msns as Sirna Delivery Vehicles for Cancer Therapy
- Gene Delivery / Drug Delivery Using Msns
- Bio-Medical Imaging
- The Imaging Capability of Msns in Biomedical
- Controlled Release of Bioactive Molecules
- Green Chemistry Application of Msns
- Protein Adsorption and Separation
- Vascular Targeting/ Passive Targeting
- Patented Citation of Mesoporous Silica Nanoparticles
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
- Reena Singh, Rahul Goel, Seema Gupta and Pradeep Kumar
- Introduction
- Polymer-Based Hydrogels
- Natural Polymer-Based Hydrogels
- Chitosan-Based Hydrogels
- Gelatin-Based Hydrogels
- Hyaluronic Acid-Based Hydrogels
- Pullulan-Based Hydrogels
- An Alginate-Based Hydrogel
- Protein-Based Hydrogel
- Synthetic Polymer-Based Hydrogels
- Polyethylene Glycol (Peg)-Based Hydrogels
- Thermally Insulated Hydrogel
- Polylactic Acid (Pla)-Based Hydrogels
- Polyvinyl Alcohol (Pva)-Based Hydrogel
- Polyacrylic Acid-Based Hydrogels
- Polyglutamic Acid-Based Hydrogels
- Poloxamer Based Hydrogel
- Polylysine-Based Hydrogel
- Peptide-Based Hydrogels
- Rada-16-Based Hydrogels
- Β-Amino Acid Peptide-Based Hydrogel
- Other Miscellaneous Polypeptide Based Hydrogels
- Future Perspectives
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 4 Metallic Nanoparticles: Applications in Drug Delivery
- Monisha Singhal, Nidhi Gupta and Jyoti Dasharath Magare
- Introduction
- Advantages of Nanoparticles-Based Drug Delivery
- Applications
- Metallic Nanoparticles
- History
- Characteristic Properties
- Gold Nanoparticles
- Methods for the Synthesis of Aunps
- Chemical Method
- Physical Methods
- Green Methods
- Biological Methods
- Application of Aunps
- Aunps as Drug Delivery on Various Diseases
- Aunps as Drug Delivery Vehicle for the Therapy of Metabolic Diseases
- Aunps as Drug Delivery Vehicles for Anti-Infective Agents
- Aunps as Drug Delivery on Cancer
- Aunps as the Delivery of Gene
- Silver Nanoparticles
- Methods for the Synthesis of Agnps
Chapter 3 Hydrogels for Drug Delivery
- Chemical Method
- Physical Method
- Green Method
- Biological Method
- Application of Agnps
- Agnps for Drug Delivery in Various Diseases
- Agnps in Wound Healing
- Agnps Impregnated on Catheters
- Agnps as Antimicrobials
- Agnps as a Tool for Sensing Applications
- Metal Oxide Nanoparticles
- Zinc Oxide Nanoparticles
- Iron Oxide Nanoparticles
- Titanium Oxide Nanoparticles
- Cerium Oxide Nanoparticles
- Copper Oxide Nanoparticles
- Silicon Dioxide or Silica Nanoparticles
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 5 Computational and Experimental Binding Interactions Of Drug and Β-Cyclodextrin as a Drug-Delivery Vehicle
- Chandrabose Selvaraj and Sanjeev Kumar Singh
- Introduction
- Chronological Evolution of Cyclodextrin
- Complex Formation in Cyclodextrin
- Physical Blending
- Slurry Complexation
- Kneading Technique
- Co-Precipitation Method
- Spray-Drying Method
- Microwave Irradiation Method
- Milling or Co-Grinding Method
- Mechanism of Drug Release from Cyclodextrin Complex
- Cyclodextrin Based Supramolecular Vesicles
- Shape and Chemistry of Cyclodextrin
- Properties of Cyclodextrins
- Computational Findings of Drug-Β-Cyclodextrin Inclusion Complex
- Docking Studies on Β-Cyclodextrin
- Cyclodextrin Based Anticancer Drugs
- Cyclodextrin as Pharmaceutical Excipients
- Pharmaceutical Applications of Cyclodextrin
- Bioavailability Enhancement
- Active Stabilization
- Irritation Reduction
- Cyclodextrin Derivatives
- Hydrophilic Derivatives
- Hydroxyalkyl Derivatives
- Sulfated Cyclodextrins
- Hydrophobic Derivatives
- Experimental Verification in Drug-Β- Cyclodextrin Inclusion
- Complex
- Thermal Analytical Technique
- X-Ray Diffraction
- Spectroscopy Studies
- Visible and Ultraviolet (Uv) Spectroscopy
- Scanning Electron Microscope
- Drug Release in Drug-Cyclodextrin
- Synthesis of Cyclodextrin
- Production of Cyclodextrin
- Solvent Process
- Success of Beta- Cyclodextrin
- Challenges and Future Perspectives
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 6 Clinical Milestones in Nanotherapeutics: Current Status
- And Future Prospects
- Ravi Goyal, Rupinder K. Sodhi and Jitender Madan
- Introduction
- Drug Targeting
- Carriers for Nanotherapeutic Formulations
- Solid Lipids Nanoparticles
- Polymeric Nanoparticles
- Nanoliposomes
- Micelles
- Dendrimers
- Nanosuspensions
- Carbon Nanotubes
- Fullerenes
- Magnetic Nanoparticles
- Nanotherapeutics in Cancer
- Cancer Imaging
- Chemotherapeutics
- Nanoliposomal Formulations
- Albumin-Bound Formulations
- Polymer-Bound Formulations
- Inorganic Nanoparticle Formulations
- Polymeric Nanoparticles
- Dendrimer Formulations
- Carbon Nanotubes Formulations
- Gold-Based Nanoparticle Formulation
- Nanotherapeutics in Cns Disorders
- Alzheimer's Disease
- Parkinson's Disease (Pd)
- Multiple Sclerosis
- Amyotrophic Lateral Sclerosis (Known as Lou Gehrig's Disease)
Author
- Surendra Nimesh
- Nidhi Gupta
- Ramesh Chandra
