Applications of Nanotechnology in Drug Discovery and Delivery, in the Drug Discovery Update series, presents complete coverage of the application of nanotechnology in the discovery of new drugs and efficient target delivery of drugs. The book highlights recent advances of nanotechnology applications in the biomedical sciences, starting with chapters that provide the basics of nanotechnology, nanoparticles and nanocarriers. Part II deals with the application of nanotechnology in drug discovery, with an emphasis on enhanced delivery of pharmaceutical products, with Part III discussing toxicological and safety issues arising from the use of nanomaterials.
This book brings together a global team of experts, making it an essential resource for researchers, drug developers, medicinal chemists, toxicologists and analytical chemists.
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Table of Contents
Part 1: Fundamentals of Nanotechnology Application in Drug Discovery 1. Nanotechnology: History, Trends and Modern Application 2. Nanomaterials as Drug Candidates: Types, Synthesis and Preparatory Methods 3. Factors Affecting the Choice for Nanoparticles in Drug Discovery 4. Nanoparticle Formulation: Types, Steps and Procedures 5. Nanocarriers: Types, Synthesis and Fabrication Methods 6. Factors Affecting the Choice for Nanocarriers for Efficient Drug Delivery Applications 7. Characterization of Nanoparticles: Methods and Techniques
Part II: Application of Nanotechnology in Drug Discovery and Therapy 8. Applications�� of Nanotechnology in Pharmaceutical Products 9. Applications of Nanotechnology in Target Identification and Validation 10. Applications of Nanotechnology in Lead Identification and Optimization 11. Application of Nanotechnology in Pharmaceutical Product Delivery 12. Application of Nanotechnology in Medicine in the Treatment of Diseases
Part III: Safety Issues and Challenges 13. Nanotoxicology: Toxicity of Nanoparticles in Biomedical Application 14.�In vitro�and�In vivo�Toxicity of Metal Nanoparticles and their Drug Delivery Applications 15. Application of Nanoelectromechanical Systems for the Detection of Toxic Chemical Agents in Pharmaceutical Products:�Nanobiosensor�Application 16. Policy Issues, Risk Assessment and Regulations of the Application of Nanotechnology in Drug Discovery
Authors
Chukwuebuka Egbuna Chukwuemeka Odumegwu Ojukwu University, Anambra State, Nigeria.Chukwuebuka Egbuna (PhD) is a chartered chemist and academic researcher. He is a member of the Institute of Chartered Chemists of Nigeria (ICCON), the Nigerian Society of Biochemistry and Molecular Biology (NSBMB), and the Royal Society of Chemistry (RSC) (United Kingdom). Dr. Egbuna is the founder and editor of the Elsevier book series on Drug Discovery Update. The series includes books, monographs, and edited collections from all areas of drug discovery including emerging therapeutic claims for the treatment of diseases. He has published research articles in many international journals of repute and is ranked among the top 500 Nigerian scientists in SciVal/SCOPUS. He has edited more than 25 books with Elsevier, Springer, Wiley, and Taylor & Francis. His most recent book is the three volume Coronavirus Drug Discovery, published by Elsevier. Dr. Egbuna is the founder and the publishing director of IPS Intelligentsia Publishing Services.
Mihnea-Alexandru Gaman Specialist, Clinical Haemotology, Department of Haemotology, Centre of Haemotology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania.Mihnea-Alexandru Gaman received his MD at the Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. Dr. Gaman is currently specializing in clinical hematology at the Department of Hematology, Centre of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania. He has published more than 100 papers in international impact factor journals, as well as served as editor and author for international and national books/book chapters. In addition, Dr. Gaman also serves as Scientific Editor, Associate Editor, Editorial Board Member and Peer-Reviewer for several international and national journals. His main fields of interest include hematology, molecular biology, oncology, internal medicine, medical education, fundamental sciences, and translational/interdisciplinary medicine.
Jaison Jeevanandam Senior Researcher, CQM - Centro De Quimica Da Madeira, MMRG, Universidade Da Madeira, Funchal, Madeira, Portugal. Dr. Jaison Jeevanandam is currently working as a senior researcher in Centro De Quimica Da Madeira (CQM - Center for Chemistry), University of Madeira, Portugal. He obtained his Ph.D. in the Department of Chemical Engineering, Faculty of Engineering and Science from Curtin University, Malaysia. He has experience in nanoparticle synthesis, especially in the green synthesis using plant extracts, characterization, cytotoxic analysis of nanoparticles, and in vitro analysis in diabetic models. His current research focuses on the application of nanobiotechnology in the development of nanoformulations for drug delivery systems. He has won several awards, including 'Best teacher award 2019' from Academy of competitive exam and research training (ACERT, Chennai), India; Gold medal in 3rd World Invention Innovation Contest (WiC) in 2017 from Korea Invention News (South Korea); Special honor of invention award, 3rd World Invention Innovation Contest (WiC) in 2017 from Toronto International Society of Innovation & Advanced Skills (TISIAS) (Canada). Dr. Jaison has authored +50 articles. Further, Dr. Jaison serves as a journal editor for Bio-integration (China) and International Archives of Biomedical and Engineering Sciences (India), as well as an invited editor for special issue in applied sciences (MDPI), Frontiers in Bioengineering and Biotechnology (Research topic coordinator) and Frontiers in molecular biosciences; and reviewer for 10+ journals.
