Rearrangements with Migration to Electrophilic Heteroatomic Centers: Timeless Classics in Organic Synthesis covers the basic principles and synthetic applications of a critically important class of organic reactions that date back to the founding period of organic chemistry. These reactions are not only of historical and pedagogical interest, but also have great practical value to this day, being inevitable in any strategy concerning the introduction of nitrogen and oxygen functionality. The book is made up of three parts, dealing with the Beckmann reaction, the Hoffmann family of reactions and the Baeyer-Villiger reaction.The book strikes a balance between delineation and exhaustiveness, with up-to-date refences for readers requiring in-depth coverage. Relevant industrial applications, including pharmaceutical processes, are included.
Table of Contents
Part I. The Beckmann RearrangementPart II. The Hoffmann and Related Rearrangements
1. Introduction (historical and current status)
Mechanistic background
Reactions and Methodology
Scope and Applications
References
2. (Curtius) Introduction (historical and current status)
Mechanistic background
Reactions and Methodology
Scope and Applications
References
3. (Lossen) Introduction (historical and current status)
Mechanistic background
Reactions and Methodology
Scope and Applications
References
PART III. The Baeyer-Villiger Reaction
Introduction (historical and current status)
Mechanistic background
Reactions and Methodology
Scope and Applications
References
