iPSCs - State of the Science, Volume Sixteen, the latest release in the Advances in Stem Cell Biology series, is an expansive collection of information and new discoveries in the field. This volume addresses the importance of induced pluripotent stems cells and how can they be derived from different sources. It addresses advances in research in induced pluripotent stem cells from alternate sources, such as spermatogonial stem cells, ovarian tissue, cancer cells, and many other sources. It is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation, and is contributed by world-renowned authors.
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Table of Contents
1. Revealing Nervous and Cardiac System Interactions by iPSC-Based Platforms 2. Human iPSC Models of Cardiac Electrophysiology and Arrhythmia 3. Human iPSCs for Modeling of Hepatobiliary Development and Drug Discovery 4. The application of iPSC-derived kidney organoids and genome editing in kidney disease modeling 5. Towards the in vitro understanding of iPSC nucleoskeletal and cytoskeletal biology, and their relevance for organoid development 6. Induced Pluripotent Stem Cell Models for Mitochondrial Disorders 7. Induced Pluripotent Stem cells for Studying Genetic Autonomic Disorders 8. Applications of iPSCs in Gaucher Disease and other rare sphingolipidoses 9. Application of CRISPR/Cas system in iPSC-based disease model of hereditary deafness 10. Progress and Possibilities for Patient-Derived iPSCs and Genetically Engineered Stem Cells in Cancer Modeling and Targeted Therapies
Authors
Alexander Birbrair Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, BrazilDepartment of Radiology, Columbia University Medical Center, Medical Center, USA. Dr. Alexander Birbrair received his bachelor's biomedical degree from Santa Cruz State University in Brazil. He completed his PhD in Neuroscience, in the field of stem cell biology, at the Wake Forest School of Medicine under the mentorship of Osvaldo Delbono. Then, he joined as a postdoc in stem cell biology at Paul Frenette's laboratory at Albert Einstein School of Medicine in New York. In 2016, he was appointed faculty at Federal University of Minas Gerais in Brazil, where he started his own lab. His laboratory is interested in understanding how the cellular components of different tissues function and control disease progression. His group explores the roles of specific cell populations in the tissue microenvironment by using state-of-the-art techniques. His research is funded by the Serrapilheira Institute, CNPq, CAPES, and FAPEMIG. In 2018, Alexander was elected affiliate member of the Brazilian Academy of Sciences (ABC), and, in 2019, he was elected member of the Global Young Academy (GYA), and in 2021, he was elected affiliate member of The World Academy of Sciences (TWAS). He is the Founding Editor and Editor-in-Chief of Current Tissue Microenvironment Reports, and Associate Editor of Molecular Biotechnology. Alexander also serves in the editorial board of several other international journals: Stem Cell Reviews and Reports, Stem Cell Research, Stem Cells and Development, and Histology and Histopathology.
