Epigenetics of Stress and Stress Disorders, a new volume in the Translational Epigenetics series, examines the epigenetic mechanisms involved in modifying DNA following prolonged stress or trauma. This is accomplished through the evaluation of both the physiological and molecular effects of stress on the body that can eventually lead to stress disorders. The book begins by providing a psychiatric, biological, and phenomenological foundation for understanding stress disorders, before delving into the genomics of stress disorders. From here, chapter authors discuss a range of recent epigenetic research in the area, highlighting epigenome-wide association studies (EWAS), exciting developments in noncoding RNA studies, possible effects of prolonged stress on telomere shortening, and the long-term physical effects of PTSD on the health of patients. The book also examines the effect of adversity during sensitive periods or development and across the life span. The book concludes by looking at possible transgenerational stress-induced epigenetic alterations on future offspring and important areas of research for public health, along with the potential for epigenetic therapeutics or "epidrugs.�
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Table of Contents
1. The physiology of stress and the human body's response to stress 2. Posttraumatic stress disorder: Diagnosis, measurement, and assessment� 3 .Nikola Tesla: An autobiographical case study of trauma and resilience 4.�Management of posttraumatic stress disorder 5. Depression and epigenetics: Epidemiology, pathophysiology, diagnosis, and assessment
6. Depression management and pharmacoepigenetics
7.�Psychotherapy for stress disorders: A military perspective
8.�How stress affects gene expression through epigenetic modifications
9.�Proposed effect of epigenetic alterations on stress-related disorders
10.�PTSD and physiology: The long-term effects of PTSD and relation to epigenetics, physical health, and chronic diseases
11.�Epigenomic biomarkers of posttraumatic stress disorder
12.�Adversity across time: Do sensitive periods across the life span determine adversity-induced epigenetic changes?
13.�PTSD, telomeres, and aging
14.�Accelerated aging in mood disorders
15.�Epigenetics, stress, and depression
16.�Capturing the epigenome: Differences among blood, saliva, and brain samples
17.�Posttraumatic stress disorder, major depressive disorder, and noncoding RNAs
18.�MicroRNAs in posttraumatic stress disorder
19.�Potential transgenerational epigenetic effects of prolonged stress and psychological trauma
20.�Targeting epigenetics as future treatments of trauma- and stress-or-related disorders. Epidrugs and epinutraceuticals
Authors
Nagy Youssef Director of Clinical Research & Professor of PsychiatryDepartment of Psychiatry & Behavioral Health
The Ohio State University College of Medicine. Dr. Nagy Youssef is an Associate Professor at the Medical College of Georgia at Augusta University, Augusta, GA, and Psychiatry Educator for medical students at the Office of Academic Affairs. His primary academic activities involve educational activities, curricula, and educational program research and development. His clinical research interests include mechanistic and therapeutic innovation for treatment-resistant psychiatric disorders and suicide prevention. He is especially interested in brain modulation therapeutics including brain stimulation as well as resilience boosting to prevent or treat severe psychiatric disorders and suicide. He has conducted research studies (as PI or co-investigator) especially in areas of treatment-resistant mood disorders and PTSD in civilians, veterans, and active duty personnel, and has presented his research in several scientific peer-reviewed publications, published abstracts, and in lectures nationally and internationally. Dr. Youssef also supervises students and residents in treating patients with a wide array of psychiatric conditions in the outpatient clinic.
