Paclitaxel: Sources, Chemistry, Anticancer Actions, and Current Biotechnology provides a comprehensive survey of Paclitaxel and its derivatives chemistry, biosynthesis and anticancer activities. In addition, biotechnological methods, including cell cultures, the use of bioreactors and metabolic engineering strategies to improve Paclitaxel production are also discussed. The book discusses topics such as mechanisms of action against cancer, novel forms of Paclitaxel for an effective cancer treatment, strategies for enhancing its bioavailability, and the application of nanocarriers for its delivery and chemotherapy of cancer.
This is a valuable resource for cancer researchers, biotechnologists and members of biomedical field who are interested in the promising anticancer qualities of this antineoplastic drug and how to enhance them for better treatments.
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Table of Contents
1. About Cancers and treatment options- An update2. Paclitaxel: Chemistry, synthetic analogues and their anticancer properties3. Taxol: Mechanisms of action against cancer, an update with current research4. Novel forms of Paclitaxel for an effective cancer cure5. Clinical pharmacology of Paclitaxel6. Strategies for enhancing bioavailability of Paclitaxel for cancer treatment7. Application of nanocarriers for Paclitaxel delivery and chemotherapy of cancer8. Paclitaxel: Cancer chemotherapy evidences, advantages, and future directions9. Anticancer Drug Paclitaxel producing plants. Their taxonomy, morphology, identification, distribution and other botanical details (it also includes color photographs of plants)10. Propagation and Micropropagation of Paclitaxel producing plants11. Biotechnology of Paclitaxel producing plants (Paclitaxel production through hairy root cultures, suspension cultures, callus cultures etc)12. Endophytes for the production of anticancer drug, Paclitaxel13. Metabolic engineering strategies to enhance the production of anticancer drug, Paclitaxel14. Paclitaxel and Chemoresistance Chapter15. Overcoming Paclitaxel Resistance16. Paclitaxel and Lung Cancer Treatment17. An update on paclitaxel treatment in Breast cancer-pros and cons
Authors
Mallappa Kumara Swamy Professor, Department of Biotechnology at East West First Grade College (Affiliated to Bangalore University), India.
Mallappa Kumara Swamy, PhD, completed his Postdoctoral Research at the Department of Crop Science, Faculty of Agriculture, Universiti Putra Malaysia (UPM), from 2014-2018. He has more than 16 years of teaching and research experience in the fields of plant biotechnology, secondary metabolites production, phytochemistry and bioactive studies. Dr. Swamy has published more than 100 research publications in peer- reviewed journals, 25 book chapters and has edited 10 books with reputed international publishers. His research focuses on the area of natural products, plant cell, tissue culture technology for bioactive compounds production and evaluation of their bioactivities, and nanobiotechnology for medical applications.
T. Pullaiah Department of Botany, Sri Krishnadevaraya University, Anantapur, India.
Professor T. Pullaiah is a former Professor at the Department of Botany at Sri Krishnadevaraya University in Andhra Pradesh, India, where he has taught for more than 35 years. He was President of Indian Botanical Society (2014), President of the Indian Association for Angiosperm Taxonomy (2013). He was awarded the Panchanan Maheshwari Gold Medal, the Prof. P.C.Trivedi Medal, the Dr. G. Panigrahi Memorial Lecture award of the Indian Botanical Society and Prof. Y.D. Tyagi Gold Medal of the Indian Association for Angiosperm Taxonomy. Under his guidance 54 students obtained their doctoral degrees. He has authored 52 books, edited 23 books and published over 330 research papers, including reviews and book chapters. He was also a member of Species Survival Commission of the International Union for Conservation of Nature (IUCN). Professor Pullaiah received his PhD from Andhra University, India, attended Moscow State University, Russia, and worked as Post-Doctoral Fellow
Zhe-Sheng Chen Editor of "African Journal of Pharmacy and Pharmacology"; Editor-in-Chief "Journal of Cancer Research Updates" and "Journal of New Developments in Chemistry".
Zhe-Sheng Chen, PhD, opened the St. John's University's first cancer pharmacology laboratory. His research interest is multidrug resistance and its reversal, novel anti-cancer drug development. Chen has over 170 papers published, co-edited Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy book (Elsevier), and holds 5 patents.
