Medical Pharmacology & Therapeutics provides all the information medical and healthcare students need throughout their degree programme and beyond, including for professional qualifications such as the PSA.
This all-round textbook covers basic pharmacology through to drug prescribing in clinical contexts, covering the pathogenic mechanisms of disease; drug actions, side effects, and the therapeutic principles of drug use. It takes a helpful systems-based approach that orders information according to body systems and disease areas, rather than by drug class.
Now in its sixth edition, the book has been fully updated to include latest scientific understanding of drug action and administration and current best practice in prescribing medications, informed by the latest national guidelines.
- A clinical focus throughout - suitable for medical, nursing and other healthcare students throughout their training
- Thorough update of clinically-relevant medicines to ensure best practice
- Information aligned with the British National Formulary (BNF), NICE guidelines and relevant professional benchmarks
- Comprehensive drug compendia allow all drugs to be identified and placed within their respective classes
- Extensive self-assessment questions to support learning and revision
- New to this edition Expanded discussion of the pathophysiology and management of shock
- Revised discussion of the management of chronic pain
- Consideration of treatment of COVID-19
- Expanded discussion of the pathophysiology and management of shock
- Revised discussion of the management of chronic pain
- Consideration of treatment of COVID-19
Table of Contents
Preface
Drug Dosage and Nomenclature
SECTION 1 GENERAL PRINCIPLES
1. Principles of Pharmacology and Mechanisms of Drug Action
2. Pharmacokinetics
3. Drug Discovery, Safety and Efficacy
4. Neurotransmission and the Peripheral Autonomic Nervous System
SECTION 2 THE CARDIOVASCULAR SYSTEM
5. Ischaemic Heart Disease
6. Systemic and Pulmonary Hypertension
7. Heart Failure and Shock
8. Cardiac Arrhythmias
9. Cerebrovascular Disease and Dementia
10. Peripheral Artery Disease
11. Haemostasis
SECTION 3 THE RESPIRATORY SYSTEM
12. Asthma and Chronic Obstructive Pulmonary Disease
13. Respiratory Disorders: Cough, Respiratory Stimulants, Cystic Fibrosis, Idiopathic Pulmonary Fibrosis and Neonatal Respiratory Distress Syndrome
SECTION 4 THE RENAL SYSTEM
14. Diuretics
15. Disorders of Micturition
16. Erectile Dysfunction
SECTION 5 THE NERVOUS SYSTEM
17. General Anaesthetics
18. Local Anaesthetics
19. Opioid Analgesics and the Management of Pain
20. Anxiety, Obsessive-Compulsive Disorder and Insomnia
21. Schizophrenia and Bipolar Disorder
22. Depression, Attention Deficit Hyperactivity Disorder and Narcolepsy
23. Seizures and Epilepsy
24. Extrapyramidal Movement Disorders and Spasticity
25. Other Neurological Disorders: Multiple Sclerosis, Motor Neuron Disease and Guillain-Barr�
Syndrome
26. Migraine and Other Headaches
SECTION 6 THE MUSCULOSKELETAL SYSTEM
27. The Neuromuscular Junction and Neuromuscular Blockade
28. Myasthenia Gravis
29. Nonsteroidal Anti-inflammatory Drugs
30. Rheumatoid Arthritis, Other Inflammatory Arthritides and Osteoarthritis
31. Hyperuricaemia, Gout and Pseudogout
SECTION 7 THE GASTROINTESTINAL SYSTEM
32. Nausea and Vomiting
33. Dyspepsia, Peptic Ulcer Disease and Gastrooesophageal Reflux Disease
34. Inflammatory Bowel Disease
35. Constipation, Diarrhoea and Irritable Bowel Syndrome
36. Liver Disease
37. Obesity
SECTION 8 THE IMMUNE SYSTEM
38. The Immune Response and Immunosuppressant Drugs
39. Antihistamines and Allergic Disease
SECTION 9 THE ENDOCRINE SYSTEM AND METABOLISM
40. Diabetes Mellitus
41. The Thyroid and Control of Metabolic Rate
42. Calcium Metabolism and Metabolic Bone Disease
43. Pituitary and Hypothalamic Hormones
44. Corticosteroids (Glucocorticoids and Mineralocorticoids)
45. Female Reproduction
46. Androgens, Antiandrogens and Anabolic Steroids
47. Anaemia and Haematopoietic Colony-Stimulating Factors
48. Lipid Disorders
SECTION 10 THE SKIN AND EYES
49. Skin Disorders
50. The Eye
SECTION 11 CHEMOTHERAPY
51. Drugs for Infections
52. Drugs for Cancer
SECTION 12 GENERAL FEATURES, TOXICITY AND PRESCRIBING
53. Drug Toxicity and Overdose
54. Substance Abuse and Dependence
55. Prescribing, Adherence and Information About Medicines
56. Drug Therapy in Special Situations
Index
Authors
Derek G. Waller Former Consultant Physician and Senior Clinical Lecturer, Department of Medicine, University Hospital Southampton, SouthamptonUnited Kingdom. Derek G. Waller, BSc, DM, MBBS, FRCP, Consultant Cardiovascular Physician, Southampton General Hospital; Senior Lecturer in Medicine and Clinical Pharmacology, University of Southampton, Southampton, UK Andrew W. Hitchings Reader in Clinical Pharmacology, St George's, University of London, Honorary Consultant in Neurointensive Care, St George's University Hospitals NHS Foundation Trust, London.
