The bone grafts and substitutes market was valued at $2.8 billion in 2023, and is projected to reach $4.4 billion by 2033, growing at a CAGR of 4.4% from 2024 to 2033.
Bone grafts and substitutes are devices that are used to replace missing or damaged bone in various medical procedures. They play a crucial role in orthopedics and spinal surgeries. The primary purpose of bone grafts and substitutes is to support the body's natural healing process by providing a scaffold for new bone growth, enhancing the repair and regeneration of bone tissue. Thus, bone grafts and substitutes serve as vital tools in modern medicine, significantly improving patient outcomes in various surgical disciplines.
The growth of the global bone grafts and substitutes market is majorly driven by alarming increase in incidence of orthopedic conditions and rise in cases of fractures and sports injuries. A study published by Wolters Kluwer, a Dutch information services company, stated that approximately two million bone grafting procedures are performed worldwide per year. Among these, 500,000 bone graft are performed annually in the U.S. alone. Moreover, surge in geriatric population significantly contributes toward the market growth. Aged individuals are highly susceptible to bone-related disorders such as osteoporosis and arthritis. This is attributed to the fact that minerals in bones of aged individuals start to leech out, making them brittle, fragile, and easily breakable, thereby necessitating the need for bone harvesters. As per the World Health Organization, the number of people aged 60 years and older was 1 billion in 2019. This number is estimated to increase to 1.4 billion by 2030 and 2.1 billion by 2050. Furthermore, shift in preference toward minimally invasive surgical techniques, which often involve bone grafts and substitutes, is notably contributing to the market growth. In addition, increase in healthcare expenditure, especially in developing regions, is improving the access to advanced orthopedic treatments, including bone grafting procedures, which acts as a significant driving force of the global market. However, high cost associated with bone grafting procedures and risk of immune rejection act as the key deterrent factors of the global market. On the contrary, innovations in graft materials and surgical techniques, such as the development of bioactive and synthetic bone grafts, have expanded the applications and improved the outcomes of bone grafting procedures, which are expected to open new avenues for the growth of the market during the forecast period. For instance, bioactive materials, such as bioactive glass and ceramics, are gaining traction due to their ability to enhance bone regeneration. Moreover, in 2020, the U.S. Food and Drug Administration approved a novel synthetic bone graft substitute designed to enhance bone healing in orthopedic and spinal surgeries, reflecting ongoing advancements and regulatory support in the market.
The global bone grafts and substitutes market analysis is segmented into type, application, end user, and region. On the basis of type, the market is categorized into allografts, bone grafts substitute, and cell-based matrices. Depending on application, it is divided into spinal fusion, trauma, craniomaxillofacial surgery, joint reconstruction, and dental bone grafting. By end user, it is classified into hospitals, specialty clinics, and others. Region wise, the market is analyzed across North America, Europe, Asia-Pacific, and LAMEA.
Depending on application, the spinal fusion segment occupied largest bone grafts and substitutes market size in 2023, and is expected to remain dominant by 2033.
By end user, the hospitals segment was the major shareholder in 2023.
Region wise, North America garnered market share in 2023, and is anticipated to continue this trend during the forecast period.
Bone grafts and substitutes are devices that are used to replace missing or damaged bone in various medical procedures. They play a crucial role in orthopedics and spinal surgeries. The primary purpose of bone grafts and substitutes is to support the body's natural healing process by providing a scaffold for new bone growth, enhancing the repair and regeneration of bone tissue. Thus, bone grafts and substitutes serve as vital tools in modern medicine, significantly improving patient outcomes in various surgical disciplines.
The growth of the global bone grafts and substitutes market is majorly driven by alarming increase in incidence of orthopedic conditions and rise in cases of fractures and sports injuries. A study published by Wolters Kluwer, a Dutch information services company, stated that approximately two million bone grafting procedures are performed worldwide per year. Among these, 500,000 bone graft are performed annually in the U.S. alone. Moreover, surge in geriatric population significantly contributes toward the market growth. Aged individuals are highly susceptible to bone-related disorders such as osteoporosis and arthritis. This is attributed to the fact that minerals in bones of aged individuals start to leech out, making them brittle, fragile, and easily breakable, thereby necessitating the need for bone harvesters. As per the World Health Organization, the number of people aged 60 years and older was 1 billion in 2019. This number is estimated to increase to 1.4 billion by 2030 and 2.1 billion by 2050. Furthermore, shift in preference toward minimally invasive surgical techniques, which often involve bone grafts and substitutes, is notably contributing to the market growth. In addition, increase in healthcare expenditure, especially in developing regions, is improving the access to advanced orthopedic treatments, including bone grafting procedures, which acts as a significant driving force of the global market. However, high cost associated with bone grafting procedures and risk of immune rejection act as the key deterrent factors of the global market. On the contrary, innovations in graft materials and surgical techniques, such as the development of bioactive and synthetic bone grafts, have expanded the applications and improved the outcomes of bone grafting procedures, which are expected to open new avenues for the growth of the market during the forecast period. For instance, bioactive materials, such as bioactive glass and ceramics, are gaining traction due to their ability to enhance bone regeneration. Moreover, in 2020, the U.S. Food and Drug Administration approved a novel synthetic bone graft substitute designed to enhance bone healing in orthopedic and spinal surgeries, reflecting ongoing advancements and regulatory support in the market.
The global bone grafts and substitutes market analysis is segmented into type, application, end user, and region. On the basis of type, the market is categorized into allografts, bone grafts substitute, and cell-based matrices. Depending on application, it is divided into spinal fusion, trauma, craniomaxillofacial surgery, joint reconstruction, and dental bone grafting. By end user, it is classified into hospitals, specialty clinics, and others. Region wise, the market is analyzed across North America, Europe, Asia-Pacific, and LAMEA.
Key Findings
On the basis of type, the bone grafts substitute segment accounted for the largest share in 2023.Depending on application, the spinal fusion segment occupied largest bone grafts and substitutes market size in 2023, and is expected to remain dominant by 2033.
By end user, the hospitals segment was the major shareholder in 2023.
Region wise, North America garnered market share in 2023, and is anticipated to continue this trend during the forecast period.
Competition Analysis
Competitive analysis and profiles of the major players in the global bone grafts and substitutes market include Arthrex, Inc, Johnson & Johnson, Medtronic plc, NuVasive, Inc., Stryker Corporation, Zimmer Biomet Holdings, Inc., Baxter International Inc., Xtant Medical Holdings, Inc., Integra LifeSciences, and Orthofix Holdings, Inc. These major players have adopted various key development strategies such as business expansion, new product launches, and partnerships to sustain the intense competition and gain a strong foothold in the global market.Additional benefits you will get with this purchase are:
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Key Market Segments
By Type
- Allografts
- Machined allografts
- Demineralized bone matrix
- Bone grafts substitutes
- Bone morphogenic proteins (BMP)
- Synthetic bone grafts
- Cell based matrices
By Application
- Spinal fusion
- Trauma
- Joint reconstruction
- Dental bone grafting
- Craniomaxillofacial
By End User
- Hospitals
- Specialty clinics
- Others
By Region
- North America
- U.S.
- Canada
- Mexico
- Europe
- France
- Germany
- Italy
- Spain
- UK
- Rest of Europe
- Asia-Pacific
- China
- Japan
- India
- South Korea
- Australia
- Rest of Asia-Pacific
- LAMEA
- Brazil
- South Africa
- Saudi Arabia
- Rest of LAMEA
- Arthrex, Inc
- Johnson & Johnson
- Medtronic plc
- NuVasive, Inc.
- Stryker Corporation
- Zimmer Biomet Holdings, Inc.
- Baxter International Inc.
- Xtant Medical Holdings, Inc.
- Integra LifeSciences
- Orthofix Holdings, Inc.
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Table of Contents
CHAPTER 1: INTRODUCTION
CHAPTER 2: EXECUTIVE SUMMARY
CHAPTER 3: MARKET LANDSCAPE
CHAPTER 4: BONE GRAFTS AND SUBSTITUTES MARKET, BY TYPE
CHAPTER 5: BONE GRAFTS AND SUBSTITUTES MARKET, BY APPLICATION
CHAPTER 6: BONE GRAFTS AND SUBSTITUTES MARKET, BY END USER
CHAPTER 7: BONE GRAFTS AND SUBSTITUTES MARKET, BY REGION
CHAPTER 8: COMPETITIVE LANDSCAPE
CHAPTER 9: COMPANY PROFILES
LIST OF TABLES
LIST OF FIGURES
Executive Summary
According to the report titled, “Bone Grafts and Substitutes Market," the bone grafts and substitutes market was at $2,586.30 million in 2021, and is projected to reach $4,005.26 million by 2031, registering a CAGR of 4.5% from 2022 to 2031.Bone grafts and substitutes are medical materials or products used to replace or augment missing or damaged bone tissue in the body. They are used in various surgical procedures to promote bone healing and regeneration, such as spinal fusion, joint reconstruction, and bone fracture repair.
Key factors driving the growth of the bone grafts and substitutes market are rise in prevalence of bone and joint disorders, rise in number of surgeries and presence of major key players offering bone grafts. For instance, according to report of Australian Orthopedic Association National Joint Replacement Registry 2022, 10.9% rise in joint replacement surgeries as compared to 2019. Thus, rise in number of surgeries is expected to fuel the growth of market. Further, rise in prevalence of musculoskeletal disorders is a major factor expected to drive the growth of the market. For instance, according to an article published in Taylor & Francis 2021, in Germany, around 64-92% of dentists reported musculoskeletal disorders. Thus, rise in musculoskeletal disorders in dentists is expected to drive the growth of the market.
Further, geriatric population is prone to many orthopedic disorders such as arthritis, back pain, and neck pain, which results in demand for bone grafts and substitutes. Thus, rise in geriatric population is expected to contribute to the growth of the bone grafts and substitutes market. For instance, data by the World Health Organization (WHO) 2021 stated that 1.4 billion of the world’s population is aged 60 years and over and is expected to double by 2050. In addition, a rise in the number of hip and knee fractures across the globe results in demand for bone grafts substitutes and thus, contributes to the market expansion.
Moreover, rising number of fractures in many countries drives the demand of bone grafts and substitutes. In Brazil, rise in prevalence of hip fractures in the elderly population due to osteoporosis is a major factor driving the growth of the market. For instance, according to an article by Archives of Osteoporosis 2022, number of hip fractures in Brazil is expected to double by 2040, reaching almost 200,000 fractures per year. Thus, rise in number of hip fractures leads to demand for bone grafts and is anticipated to drive the growth of the market.
Further, rise in adoption of strategies such as contract, partnership and strategic alliance by key players of market is expected to propel the market expansion. For instance, in July 2021, Integra LifeSciences Holding Corporation, a leading global medical technology company, announced contract with Vizient, Inc. for manufacturing of SurgiMend Collagen Matrix for soft tissue. Thus, rise in such adoption of such strategies drive the market growth.
The market also offers growth opportunities to the key players in the market. Many developing regions such India and Brazil offer lucrative opportunities to key players of bone grafts and substitutes market owing to high population base, increase in demand of advanced bone graft substitutes and increase in healthcare spending. In addition, government initiatives regarding orthopedic disorders and surgeries in various countries and medical tourism fuels the growth of market.
The bone grafts and substitutes market is segmented into type, application, end user and region. On the basis of type, the market is categorized into allografts, bone grafts substitute and cell-based matrices. On the basis of application, the market is divided into spinal fusion, trauma, craniomaxillofacial surgery, joint reconstruction and dental bone grafting. On the basis of end user, the market is classified into hospitals, specialty clinics and others. Region wise, the market is analyzed across North America (the U.S., Canada, and Mexico), Europe (Germany, France, the UK, Italy, Spain, and rest of Europe), Asia-Pacific (Japan, China, Australia, India, South Korea, and rest of Asia-Pacific), and LAMEA (Brazil, South Africa, Saudi Arabia, and rest of LAMEA).
The key players profiled in the study include Arthrex, Inc., Johnson & Johnson, Medtronic plc, NuVasive, Inc., Stryker Corporation, Zimmer Biomet Holdings, Inc., Baxter International Inc., Xtant Medical Holdings, Inc., Integra LifeSciences and Orthofix Holdings, Inc. The players in the market have been actively engaged in the adoption various strategies such as acquisition, product launch, product approval, partnership, strategic alliance and contract to remain competitive and gain advantage over the competitors in the market.
Key Market Insights
- On the basis of type, the bone graft substitutes segment was highest contributor to the market in 2021.
- On the basis of application, the spinal fusion segment dominated the market in terms of revenue in 2021. However, the joint reconstruction segment is anticipated to grow at the highest CAGR during the forecast period.
- On the basis of end user, the hospitals segment dominated the market in terms of revenue in 2021.
- Region wise, North America generated the largest revenue in 2021. However, Asia-Pacific is anticipated to grow at the highest CAGR during the forecast period.
Companies Mentioned
Key Market Players in the Bone Grafts and Substitutes Market include:- Arthrex, Inc
- Johnson & Johnson
- Medtronic plc
- NuVasive, Inc.
- Stryker Corporation
- Zimmer Biomet Holdings, Inc.
- Baxter International Inc.
- Xtant Medical Holdings, Inc.
- Integra LifeSciences
- Orthofix Holdings, Inc.
Methodology
The analyst offers exhaustive research and analysis based on a wide variety of factual inputs, which largely include interviews with industry participants, reliable statistics, and regional intelligence. The in-house industry experts play an instrumental role in designing analytic tools and models, tailored to the requirements of a particular industry segment. The primary research efforts include reaching out participants through mail, tele-conversations, referrals, professional networks, and face-to-face interactions.
They are also in professional corporate relations with various companies that allow them greater flexibility for reaching out to industry participants and commentators for interviews and discussions.
They also refer to a broad array of industry sources for their secondary research, which typically include; however, not limited to:
- Company SEC filings, annual reports, company websites, broker & financial reports, and investor presentations for competitive scenario and shape of the industry
- Scientific and technical writings for product information and related preemptions
- Regional government and statistical databases for macro analysis
- Authentic news articles and other related releases for market evaluation
- Internal and external proprietary databases, key market indicators, and relevant press releases for market estimates and forecast
Furthermore, the accuracy of the data will be analyzed and validated by conducting additional primaries with various industry experts and KOLs. They also provide robust post-sales support to clients.
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Table Information
| Report Attribute | Details |
|---|---|
| No. of Pages | 260 |
| Published | July 2024 |
| Forecast Period | 2023 - 2033 |
| Estimated Market Value ( USD | $ 2.8 billion |
| Forecasted Market Value ( USD | $ 4.4 billion |
| Compound Annual Growth Rate | 4.4% |
| Regions Covered | Global |
| No. of Companies Mentioned | 11 |
