Global Fibroblast Growth Factor Receptor Inhibitor Drug Market Opportunity & Clinical Trials Insight 2026 Report Highlights:
- Global FGFR Inhibitors Market Opportunity: > USD 4 Billion by 2026
- Role of FGFR Inhibitors in Cancer Therapy
- Global FGFR Market Assessment (US$) by Region & Cancer Type
- Clinical & Sales Insight on Approved FGFR Inhibitors: 3 (Belvesra, Pemazyre & Truseltiq)
- Dosage & Drug Price Insight on Approved FGFR Inhibitors
- Comprehensive Clinical Trials Insight by Company, Country, Phase & Patient Segment: 53 Drugs in Trials
Recent breakthrough with respect to small molecule-based therapy in the oncology segment has set up remarkable achievements in terms of improving the cancer survival rate. The FGFR inhibitors are considered as one of advanced anticancer therapy, which belongs to the class of receptor kinase inhibiting small molecules and now widely accepted for the treatment of various cancer types including bladder cancer, breast cancer, lung cancer gastric cancer, lymphoma, myeloma etc. In a short period of time, FGFR inhibitors has made its way through all the challenges and led to a stage where the availability of the therapy is highly appreciated and praised.
The mutation or overexpression of FGFR makes them an ideal target for the management of cancer and most of the researchers exploring the therapeutic potential of this class concluded the beneficial effects of this approach. Further, the FGFR alterations are also observed in rare cancers and hence this approach has the potential to play a crucial role in the management of untreatable rare types of cancers. Currently, the market of FGFR inhibitors is at nascent stage, which is driven by the sales of 3 approved products of this class i.e. Balversa, Pemazyre and Truseltiq. Balversa is recommended for the management of bladder cancer while Pemazyre and Truseltiq are recommended for the management of rare cancer termed as Cholangiocarcinoma. Many new drugs of this class are also believed to get orphan designation in upcoming years, which further boost the market size of this segment.
Balversa is expected to lead the market segment as its sales value is believed to increase exponentially after its approval in the leading regions including Europe and Japan. The estimated market size of FGFR inhibitor is about US$ 100 Million in the year 2020 and it is believed to grow with a CAGR of more than 80% during the next 6 years as most of the market-related factors are indicating the increasing acceptance of this segment in near future. Further, US will lead the FGFR market due to the availability of a huge cancer burden and leading pharmaceutical companies. The drug approval process is now simplified in US due to the availability of all the three drugs of this class and hence most of the new FGFR inhibitors will first get approval in this region.
With an aim of improving the market penetrability and commercialization of FGFR inhibitors, the leading pharmaceutical companies are expected to collaborate with CROs and regional pharmaceutical companies of developing companies, which will increase the market size of this novel segment in regions such as Asia-Pacific, Middle-East and Latin America. The leading pharmaceutical companies working in this sector are Amgen, Astem pharma, AstraZeneca, Bayer, BMS, Incyte, Roche, Taiho, Janssen pharmaceuticals, Novartis etc. while many other companies are working on FGFR inhibitors in preclinical studies.
The “Global Fibroblast Growth Factor Receptor Inhibitor Drug Market Opportunity & Clinical Trials Insight 2026” report involves in depth analysis of the various parameters related to this segment along with the analysis of current as well as future market opportunity. The report also analyzes the wide range of applications of this class in cancer management along with the clinical trends, market drivers, and possible challenges related to FGFR inhibitors market. Further, multiple parameters are considered to forecast and analyze the global, regional and indication based market size for FGR inhibitors drugs.
Table of Contents
1. Introduction to FGFR Inhibitors
1.1 Overview
1.2 Evolution of FGFR Inhibitors
2. FGFR Inhibitors - Mechanism of Action
3. Role of FGFR Inhibitors in Cancer Therapy
3.1 AZD4547
3.2 E7090
3.3 Debio 1347
3.4 Futibatinib
3.5 Rogaratinib
3.6 Derazantinib
3.7 RLY-4008
3.8 CPL304110
4. Global FGFR Inhibitor Market Analysis
4.1 Current Market Scenario
4.2 Future Market Opportunity
5. Global FGFR Inhibitors Market Opportunity by Region
5.1 US
5.2 Europe
5.3 Japan
5.4 Rest of World
6. Global FGFR Inhibitors Market Opportunity by Cancer
6.1 Cholangiocarcinoma
6.2 Urothelial Carcinoma
6.3 Lymphoma
6.4 Lung Cancer
7. Balversa - First Approved FGFR Inhibitor 2019
7.1 Overview
7.2 Patent Insight
8. Balversa - Comercial Availability, Dosage & Price Analysis
9. Pemazyre - Second Approved FGFR Inhibitor 2020
9.1 Overview
9.2 Patent Insight
10. Pemazyre - Commercial Information
10.1 Dosage & Price Analysis
10.2 Sales Analysis
11. Truseltiq - Third Approved FGFR Inhibitor Drug 2021
11.1 Overview
11.2 Patent Insight
12. Truseltiq - Commercial Availability, Dosage & Price Analysis
13. Global Sales Forecast - 2021 Till 2026
13.1 Belvesra
13.2 Pemazyre
13.3 Truseltiq
14. FGFR Inhibitors - Ongoing Clinical Trials
14.1 By Phase
14.2 By Development Status
14.3 By Region
15. Global - FGFR Inhibitors in Clinical Trials
15.1 Research
15.2 Preclinical
15.3 Phase-I
15.4 Phase-I/II
15.5 Phase-II
15.6 Phase-II/III
15.7 Phase-III
15.8 Preregistration
16. Marketed FGFR Inhibitors Drugs Clinical Insight
17. Global FGFR Inhibitors Market Dynamics
17.1 Drivers for Global FGFR Inhibitors Market
17.2 Global FGFR Inhibitors Market Challenges
18. Global FGFR Inhibitors Market Future Outlook
19. Competitive Landscape
19.1 Amgen
19.2 Astex Pharmaceuticals
19.3 AstraZeneca
19.4 Bayer
19.5 Blueprint Medicine
19.6 Boehringer Ingelheim International
19.7 Bristol Mayer Squibb
19.8 Incyte Corporation
19.9 Janssen Pharmaceuticals
19.10 Novartis International
19.11 Pfizer Inc
19.12 Roche
19.13 Taiho
19.14 TransThera Biosciences
List of Tables
Table 6-1: Global - Estimated Adoption Rates for Cholangiocarcinoma Targeting FGFR Inhibitors, 2021-2026
Table 6-2: Global - Estimated Adoption Rates for Cholangiocarcinoma Targeting FGFR Inhibitors, 2021-2026
Table 6-3: Global - Estimated Adoption Rates for NHL Targeting FGFR Inhibitors, 2021-2026
Table 6-4: Global - Estimated Adoption Rates for Lung Cancer Targeting FGFR Inhibitors, 2021-2026 "
List of Figures
Figure 1-1: History of FGFR Inhibitors
Figure 2-1: General Mechanism of FGFR Inhibitors
Figure 2-2: Balversa - Mechanism of Action Against Urothelial Cancer
Figure 2-3: Mechanism of Pemazyre & Truseltiq Against Cholangiocarcinoma
Figure 3-1: FGFR Mutational Frequency by Cancer Type (%)
Figure 3-2: Roles of FGFR Inhibitors in Cancer
Figure 3-3: Investigational FGFR Inhibitors
Figure 3-4: E7090 Phase II Trial - Study Initiation & Completion Year
Figure 3-5: E7090 Phase II Fortune Trial - Study Initiation & Completion Year
Figure 3-6: E7090 Phase I Trial - Study Initiation & Completion Year
Figure 3-7: Debio 1347 Phase II Trial - Study Initiation & Completion Year
Figure 3-8: Debio 1347 Phase I-II Trial - Study Initiation & Completion Year
Figure 3-9: Futibatinib Phase II Trial - Study Initiation & Completion Year
Figure 3-10: Futibatinib & Pembrolizumab Phase II Trial - Study Initiation & Completion Year
Figure 3-11: Futibatinib & Binimetinib Phase I-II Trial - Study Initiation & Completion Year
Figure 3-12: Futibatinib & Fulvestrant Phase I-II Trial - Study Initiation & Completion Year
Figure 3-13: Rogaratinib Phase II Trial for NSCLC - Study Initiation & Completion Year
Figure 3-14: Rogaratinib Phase II Trial for GIST - Study Initiation & Completion Year
Figure 3-15: Rogaratinib Phase I-II Trial - Study Initiation & Completion Year
Figure 3-16: Rogaratinib Phase I Trial - Study Initiation & Completion Year
Figure 3-17: Derazantinib Phase II Trial - Study Initiation & Completion Year
Figure 3-18: Derazantinib Phase I-II Trial - Study Initiation & Completion Year
Figure 3-19: Derazantinib/Atezolizumab Phase II Trial - Study Initiation & Completion Year
Figure 3-20: RLY4008 Phase I Trial - Study Initiation & Completion Year
Figure 3-21: CPL304110 Phase I Trial - Study Initiation & Completion Year
Figure 4-1: Global - Number of Newly Diagnosed Cancer Cases (Million), 2020, 2025 & 2030
Figure 4-2: Global - Number of Cancer Deaths (Million), 2020, 2025 & 2030
Figure 4-3: Global - FGFR Inhibitors Market Opportunity (US$ Million), 2020-2026
Figure 4-4: Global - Cancer Drug Market Opportunity (US$ Billion), 2020-2026
Figure 4-5: Global - FGFR Inhibitors Market by Product (%) 2026
Figure 5-1: US - Number of Newly Diagnosed Cancer Cases (Million), 2020-2026
Figure 5-2: US - FGFR Inhibitors Market Opportunity (US$ Million), 2020-2026
Figure 5-3: US - FGFR Inhibitors Market by Product (%) 2026
Figure 5-4: Europe - Number of Newly Diagnosed Cancer Cases (Million), 2020-2026
Figure 5-5: Europe - FGFR Inhibitors Market Opportunity (US$ Million), 2021-2026
Figure 5-6: Europe - FGFR Inhibitors Market by Product (%) 2026
Figure 5-7: Japan - Number of Newly Diagnosed Cancer Cases (Million), 2020-2026
Figure 5-8: Japan - FGFR Inhibitors Market Opportunity (US$ Million), 2022-2026
Figure 5-9: Japan - FGFR Inhibitors Market by Product (%) 2026
Figure 5-10: ROW - FGFR Inhibitors Market Opportunity (US$ Million), 2022-2026
Figure 5-11: ROW - FGFR Inhibitors Market by Product (%), 2026
Figure 6-1: Global - Number of Cholangiocarcinoma Cases, 2021-2026
Figure 6-2: Global - Cholangiocarcinoma Targeting FGFR Inhibitors Market Opportunity (US$ Million), 2021-2026
Figure 6-3: Global - Number of Urotheluial Carcinoma Cases, 2021-2026
Figure 6-4: Global - Urothelial Carcinoma Targeting FGFR Inhibitors Market Opportunity (US$ Million), 2021-2026
Figure 6-5: Global - Number of NHL Cases, 2021-2026
Figure 6-6: Global - NHL Targeting FGFR inhibitors Market Opportunity (US$ Million), 2023 - 2026
Figure 6-7: Global - Number of Newly Diagnosed Lung Cancer Cases (Million), 2020-2026
Figure 6-8: Global - Lung Cancer Targeting FGFR inhibitors Market Opportunity (US$ Million), 2022 - 2026
Figure 7-1: Balversa - Patent Issue & Expiration Year
Figure 8-1: Balversa - Price for 56 Tablets Supply & Price per Unit of 3mg Tablet (US$), July’2021
Figure 8-2: Balversa - Price for 84 Tablets Supply & Price per Unit of 3mg Tablet (US$), July’2021
Figure 8-3: Balversa - Price for 28 Tablets Supply & Price per Unit of 4mg Tablet (US$), July’2021
Figure 8-4: Balversa - Price for 56 Tablets Supply & Price per Unit of 4mg Tablet (US$), July’2021
Figure 8-5: Balversa - Price for 28 Tablets Supply & Price per Unit of 5mg Tablet (US$), July’2021
Figure 8-6: Balversa - Initial & Maintenance Dose (mg/Day)
Figure 8-7: Balversa - Initial Dose After Reduction (mg/Day)
Figure 8-8: Balversa - Maintenance Dose After Reduction (mg/Day)
Figure 9-1: Pemazyre - Approval Year by Region
Figure 9-2: Pemazyre - Patent Issue & Expiration Year
Figure 10-1: US - Price for 14 Tablets Supply & Price per Unit of Various Doses of Pemazyre (US$), July’2021
Figure 10-2: Europe - Price for 14 Tablets Supply & Price per Unit of Various Doses of Pemazyre (US$), July’2021
Figure 10-3: Pemazyre - Duration of Single Treatment Cycle by Phase (days)
Figure 10-4: Pemazyre - Initial & Reduced Dose (mg/day)
Figure 10-5: Global - Pemazyre Quarterly Sales (US$ Million), 2020
Figure 11-1: Truseltiq - FDA Approval & Orphan Designation Year
Figure 11-2: Truseltiq - Patent Issue & Expiration Year
Figure 12-1: Truseltiq - Price for 42 Capsules Supply & Price per Unit of Dose 125mg (US$), August’2021
Figure 12-2: Truseltiq - Price for 42 Capsules Supply & Price per Unit of Dose 50mg (US$), August’2021
Figure 12-3: Truseltiq - Price for 63 Capsules Supply & Price per Unit of Dose 75mg (US$), August’2021
Figure 12-4: Truseltiq - Price for 21 Capsules Supply & Price per Unit of Dose 100mg (US$), August’2021
Figure 12-5: Truseltiq - Duration of Single Treatment Cycle by Phase (days)
Figure 12-6: Truseltiq - Initial & Reduced Dose (mg/day)
Figure 13-1: Global - Balversa Sales Forecast (US$ Million), 2021-2026
Figure 13-2: US - Balversa Sales Forecast (US$ Million), 2021-2026
Figure 13-3: Europe - Balversa Sales Forecast (US$ Million), 2022-2026
Figure 13-4: Japan - Balversa Sales Forecast (US$ Million), 2022-2026
Figure 13-5: ROW - Balversa Sales Forecast (US$ Million), 2022-2026
Figure 13-6: Global - Pemazyre Sales Forecast (US$ Million), 2021-2026
Figure 13-7: US - Pemazyre Sales Forecast (US$ Million), 2021-2026
Figure 13-8: Europe - Pemazyre Sales Forecast (US$ Million), 2022-2026
Figure 13-9: Japan - Pemazyre Sales Forecast (US$ Million), 2022-2026
Figure 13-10: ROW - Pemazyre Sales Forecast (US$ Million), 2022-2026
Figure 13-11: Global - Truseltiq Sales Forecast (US$ Million), 2021-2026
Figure 13-12: US - Truseltiq Sales Forecast (US$ Million), 2021-2026
Figure 13-13: Europe - Truseltiq Sales Forecast (US$ Million), 2022-2026
Figure 13-14: Japan - Truseltiq Sales Forecast (US$ Million), 2022-2026
Figure 13-15: ROW - Truseltiq Sales Forecast (US$ Million), 2022-2026
Figure 14-1: Pemazyre - Number of Clinical Trials by Phase, July’2021
Figure 14-2: Pemazyre - Number of Clinical Trials by Phase, July’2021
Figure 14-3: Pemazyre - Number of Clinical Trials by Development Status, July’2021
Figure 14-4: Pemazyre - Number of Clinical Trials by Development Status (%), July’2021
Figure 14-5: Pemazyre - Number of Clinical Trials by Region, July’2021
Figure 15-1: Global - Number of FGFR Inhibitors Drugs in Clinical Trials by Phase, 2021 till 2026
Figure 15-2: Global - Number of FGFR Inhibitors Drugs in Clinical Trials by Company, 2021 till 2026
Figure 15-3: Global - Number of FGFR Inhibitors Drugs in Clinical Trials by Patient Segment, 2021 till 2026
Figure 15-4: Global - Number of FGFR Inhibitors Drugs in Clinical Trials by Country, 2021 till 2026
Figure 17-1: Global FGFR Market Drivers
Figure 17-2: Challenges for Global FGFR Inhibitors Market
Figure 17-3: US - Annual Treatment Cost Comparison Using Various Drugs (US$), August’2021
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Companies Mentioned (Partial List)
A selection of companies mentioned in this report includes, but is not limited to:
- Amgen
- Astex Pharmaceuticals
- AstraZeneca
- Bayer
- Blueprint Medicine
- Boehringer Ingelheim International
- Bristol Mayer Squibb
- Incyte Corporation
- Janssen Pharmaceuticals
- Novartis International
- Pfizer
- Roche
- Taiho
- TransThera Biosciences
