Genetic Engineering and Genome Editing for Zinc Biofortification of Rice provides the first single-volume comprehensive resource on genetic engineering approaches, including novel genome editing techniques, to be carried out in rice, a staple crop for much of the world's population. While zinc biofortification can be achieved through conventional breeding, genetic engineering, and agronomic practices, this book presents the latest developments, based on real-world experience and with targeted application. Dietary zinc deficiency can lead to negative health outcomes, including increased risk of stunting, respiratory diseases, diarrhea and mortality during childhood, and preterm births in pregnancy. Although providing access to diverse diet is an ideal solution to alleviate zinc deficiency, it may not be a viable solution in developing countries. Zinc biofortification, a process of increasing zinc concentration in the edible part of food crops, has been proposed as a sustainable approach that can reach people living in remote rural areas, complementing other interventions, such as supplementation and industrial fortification. Providing a complete view of the need for, and means of, zinc biofortification in rice, sections in this book discuss state-of-the-art scientific advances, and then goes further, placing them in their proper scientific, regulatory, and socioeconomic contexts. Thus, Genetic Engineering and Genome Editing for Zinc Biofortification of Rice is a valuable resource for graduate students, researchers, educators, librarians, and professionals in various kinds of institutions which focused on agriculture, environmental science, and plant science.
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Table of Contents
1. Molecular mechanisms leading to grain Zn accumulation in rice 2. Molecular links between iron and zinc biofortification in rice 3. Nicotianamine enhances zinc transport to seeds for biofortification 4. Zinc biofortification of rice by engineering metal transporter genes 5. Decreasing cadmium content in zinc biofortified rice through genetic manipulation 6. Improving bioavailability of zinc in rice grains by reducing antinutrients through genetic engineering 7. Practical protocol for design and construction of a transformation vector for prime editing in rice 8. Stages of development of genetically modified (GM) plants 9. Leveraging intellectual property for the development of genome edited crops by public research institutes 10. Recent advances in precise plant genome editing technology 11. Pathway from laboratory to market: regulatory approval process during the development of genetically modified crops--Philippine perspective 12. Prospects and challenges associated with GM biofortified crops 13. Economic feasibility of genetically modified zinc-fortified rice 14. Ionomics-based imaging, localization and quantification of zinc and other micronutrients in rice grains for biofortification researchAuthors
B.P. Mallikarjun Swamy Currently Senior Scientist I-Senior Breeder, IRRI, Los Banos, Laguna, Philippines. PhD in Genetics, Osmania University, Hyderabad, IndiaMSc in Genetics and Plant Breeding, University of Agricultural Sciences, Dharwad, Karnataka, India;
BSc (Agriculture), University of Agricultural Sciences, Bangalore, Karnataka, India
Professional Experience:
Currently Senior Scientist I-Senior Breeder, IRRI, Los Banos, Laguna, Philippines
Scientist II- Rice Breeder, IRRI, Los Banos, Laguna, Philippines
Scientist I-Rice Breeder, at IRRI, Los Banos, Laguna, Philippines
Postdoctoral Fellow - at IRRI, Los Banos, Laguna, Philippines
Visiting Research Fellow - at IRRI, Los Banos, Laguna, Philippines
Senior Research Fellow (CSIR)- Indian Institute of Rice Research, Hyderabad, India
Junior Research Fellow (CSIR)- Indian Institute of Rice Research, Hyderabad, India
Senior Research Fellow (ICAR) -Indian Institute of Rice Research, Hyderabad, India
Main research topics: Breeding for healthier rice varieties, high beta-carotene, iron and zinc. Anca Macovei Assistant Professor, Department of Biology and Biotechnology (Plant Biotechnology Laboratory), University of Pavia, Italy. Dr. Anca Macovei earned a degree in Biology and a Masters Degree in Plant Genetic Engineering at the 'Babes-Bolyai' University in Cluj-Napoca (Romania) followed by a PhD Degree in Genetics and Molecular Biology at the University of Pavia (Italy). Post-doc fellowships were at the International Center for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India and International Rice Research Institute (IRRI), Manila, Philippines Currently, an Assistant Professor at the Department of Biology and Biotechnology (Plant Biotechnology Laboratory), University of Pavia (Italy), main research topics are molecular profiling of seed quality, plant DNA Damage Response (DDR). Kurniawan Rudi Trijatmiko Scientist I, Genetic Transformation Laboratory, International Rice Research Institute, Los Banos, Laguna, Philippines. Dr. Kurniawan Rudi Trijatmiko earned a degree in Agriculture at the Gadjah Mada University in Yogyakarta (Indonesia) in 1994. Master Degree in Biotechnology at the Bogor Agricultural University (Indonesia) in 2000. PhD Degree in Plant Sciences at the Wageningen University (Netherlands) in 2005.Following Post-doc fellowships at the International Rice Research Institute (IRRI), Los Ba�os, Philippines (2009-2011) and Project Scientist at IRRI (2014-2016). Dr.Trijatmiko is currently working as a Scientist I at the Genetic Transformation Laboratory, IRRI with focus on main research topics: engineering rice for high beta-carotene, iron and zinc.
