Overview
Small molecule drugs account for nearly 90% of the contemporary therapeutics pipeline. In 2020, the US FDA’s Center for Drug Evaluation and Research approved 35 small molecule drugs, representing 66% of the total number of new molecular entities (NMEs) clearing regulatory review in the same year. It is worth highlighting that the process of drug development, beginning from the discovery of a pharmacological lead to the commercialization of a clinically validated product, takes around 10-15 years. Moreover, drug discovery and clinical research are capital intensive processes, which, on average, require investments in the range of USD 4-10 billion. Further, it is a well-known fact that only a small proportion of lead molecules that are shortlisted for further investigation during the discovery phase, actually make it into the clinical phase, and an even lesser number of product candidates enter the market. Therefore, to optimize on internal resource utilization and save costs, innovator companies in the pharmaceutical industry are increasingly outsourcing various aspects of their discovery-stage operations to specialty contract research organizations (CROs).
Modern CROs offer a plethora of pharmaceutical discovery (such as target discovery & validation, hit identification (using strategies such as high-throughput screening, fragment-based screening, virtual screening, knowledge-based screening and DNA-encoded libraries), and lead generation / optimization) and product development related services, leveraging a variety of advanced technologies to cater to the evolving needs of sponsors / clients. As indicated earlier, engaging third party service providers offers both time and cost related benefits to drug / therapy developers. Currently, over 500 companies / organization claim to be actively providing contract research services for small molecule drugs. In the recent past, many of the service providers in this domain forged strategic alliances and / or acquired other players, in order to further enhance their respective service portfolios and thereby, consolidate their presence in the industry. The aforementioned developments may be attributed to the growing preference for one-stop-shops among sponsor companies, and the gradual acceptance of outsourcing as a viable and beneficial operating model. Based on prevalent trends and projections of how the pharmaceutical pipeline is likely to evolve over the coming years, we believe that demand for pharmaceutical CROs is going to grow at a steady pace. Consequently, the small molecule drug discovery and development services market is anticipated to witness consistent growth till 2030.
Scope of the Report
The "Pharmaceutical Contract Research Services Market, 2021-2030" report features an extensive study on contract service providers engaged in discovery, preclinical and clinical research of small molecule drugs. The study features in-depth analysis, highlighting the capabilities of various industry stakeholders engaged in this field.
Amongst other elements, the report includes:
- A detailed review of the overall landscape of the pharmaceutical services market, highlighting the contributions of CROs, along with information on their year of establishment, company size, scale of operation (discovery, preclinical and clinical), location of headquarters, type(s) of services offered (target discovery & validation, hit identification, hit-to-lead & lead generation, lead optimization, bioanalytical studies, other preclinical services, clinical trials related services, consulting and regulatory affairs management), hit identification strategy used (high-throughput screening, fragment based screening, virtual screening (structure based virtual screening, ligand based virtual screening and unspecified virtual screening), knowledge based screening, DNA Encoded Library (DEL) based screening and others), type of business model (fee-for-service and full time equivalent) and target therapeutic area.
- Elaborate profiles of prominent CROs engaged in offering pharmaceutical related services. Each company profile features a brief overview of the company, its financial information (if available), service portfolio and recent developments and an informed future outlook.
- An insightful competitiveness analysis, highlighting prominent pharmaceutical contract service providers based on supplier strength (considering a company's years of experience), and service strength (which takes into account the service offerings, scale of operation, hit identification strategies and subject specific agreements).
- An analysis of the recent collaborations (signed since 2018) focused on the CROs offering pharmaceutical related services, based on various parameters, such as year of agreement, type of agreement, scale of operation and target therapeutic area.
- A detailed analysis of the various mergers and acquisitions that have taken place in this domain, during the period 2018-2021. It is worth mentioning that the data captured during our research was analyzed based on multiple parameters, such as year, type of acquisition and geographical location of the companies.
- A region-wise, detailed analysis of the total cost of ownership for a pharmaceutical contract research service provider. It features an informed estimate of direct and indirect expenses taking into consideration close to 100 relevant parameters over a span of 20 years.
- A case study on the current market landscape of biopharmaceutical contract research service providers, including information on the year of establishment, company size, scale of operation and type of services offered.
One of the key objectives of this report was to evaluate the current opportunity and the future potential of the pharmaceutical CROs market over the coming decade. We have provided an informed estimate on the likely evolution of the market in the short to mid-term and long term, for the period 2021-2030. The report also features the likely distribution of the current and forecasted opportunity across [A] scale of operation (discovery services, preclinical services and clinical stage services), [B] target therapeutic area (cardiovascular disorder, dermatological disorders, infectious disorder, inflammatory disorder, neurological disorder, oncological disorder, ophthalmological disorder, respiratory disorder and other disorders) and [C] key geographical region (North America, Europe, Asia-Pacific, Latin America, MENA (Middle East and North Africa) and rest of the world). In order to account for future uncertainties and to add robustness to our model, we have provided three market forecast scenarios, namely conservative, base and optimistic scenarios, representing different tracks of the industry's growth. The opinions and insights presented in the report were also influenced by discussions held with senior stakeholders in the industry.
All actual figures have been sourced and analyzed from publicly available information forums and inputs from primary research. Financial figures mentioned in this report are in USD, unless otherwise specified.
Key Questions Answered
- Who are the leading players offering contract research services for small molecules?
- Which partnership models are commonly adopted by stakeholders engaged in this industry?
- What are the key value drivers of the merger and acquisition activity observed within this domain?
- What are the likely future trends in contract research services market?
- How is the current and future opportunity likely to be distributed across key market segments?
- What is the total cost of ownership required to set up a pharmaceutical contract research organization?
Table of Contents
Companies Mentioned (Partial List)
A selection of companies mentioned in this report includes, but is not limited to:
- 2bind
- 4Clinics
- A+ Science
- A10 Clinical Solutions
- A2 Healthcare
- Aaranya Biosciences
- AbClon
- Absolute Research Solutions
- Absorption Systems
- Accelera
- Accelero Biostructures
- Accell Clinical Research
- Accelsiors
- Accre Chemicals
- Accuprec Research Labs
- Accutest Research Laboratories
- ACD/Labs
- ACEA Biosciences
- ACI Clinical
- Aclaris Therapeutics
- ACLIRES International
- ACM Global Laboratories
- aCROnordic
- ACROVAN
- Actimus Bio
- Activa Cro
- Addex Therapeutics
- Adesis
- Advanced Clinical
- Advanced Drug and Device Services (ADDS)
- Aepodia
- African Clinical Research Organization (ACRO)
- Agilent
- AGINKO Research
- Agno Pharma
- AiPing Pharmaceutical
- AIT Bioscience
- Aix Scientifics
- Aizant Drug Research Solutions
- Akcelis
- Albuquerque Clinical Trials
- Alcami
- Alimentiv
- Alira Health
- Alliance Pharma
- Allphase Clinical Research
- Almac
- Almirall
- Alpha Bioresearch
- Alpha Genesis (AGI)
- Altasciences
- Althian- Clinical Research Management Center
- Altiora
- Alturas Analytics
- Amarex Clinical Research
- AmbioPharma
- Amedes
- American Preclinical Services
- AML Clinical Services
- AMRI
- Anabase International
- Analgesic Solutions
- Anapharm Bioanalytics
- Anavo Therapeutics
- ANI Pharmaceuticals
- Anova Enterprises
- AnSys Laboratories
- ANTAEA
- Antev
- APCER Life Sciences
- APEIRON Biologics
- A-Pharma
- Appletree CI Group
- Applied Healthcare Resource Management (AHRM)
- APRO
- ARCHIMEDlife
- Arcinova
- Argint International Clinical Research and Development Services (Argint)
- Aris Pharmaceuticals
- Array Biostatistics (Acquired by CATO SMS)
- Asclepia Medchem Solutions
- Asia Global Research (AGR)
- Asiatic Clinical Research
- ASINEX
- ASSAY Clinical Research
- Assay.Works
- Astron Research
- AstronauTx
- Atlant Clinical
- Atuka
- August Bioservices
- Auriga Research
- Aurigene Pharmaceutical Services
- Aurora Fine Chemicals
- Aurum Clinical Research (ACR)
- Avance Clinical (formerly CPR Pharma Services)
- Averica Discovery
- Avistron Chemistry Services
- Avitacor
- AVVA Pharmaceuticals
- AXIS Clinicals
- Axon Clinical Research
- Axon Medchem
- Axxam
- Azidus
- BalticCRO
- Biomedical Advanced Research and Development Authority (BARDA)
- BASF
- Baxter
- Bayer
- BBK Worldwide
- BePharBel Manufacturing
- Bienta (a part of Enamine Biology Services)
- BioAge Labs
- Bioanalytical Laboratory Services (BLS)
- BioAscent
- BioBlocks
- Bioclinica
- BioDuro
- Biogen
- Biognos
- BIOMAPAS CODE OF ETHICS
- Biomere
- Bioneeds
- Bionicsgene
- BioNTech
- BioPharma Services
- BioPredict
- Biorasi Clinical Research
- BioReliance
- bioskin
- BioSolveIT
- Biospective
- BioStat International
- BioTek Instruments (part of Agilent Technologies)
- Biotoxtech
- Biotrial
- Biotrofix
- Biovantix
- BioVectra
- BlueClinical
- Blueprint Genetics
- BOC Sciences
- Boston MedTech Advisors
- BPI Service (subsidiary of Federal Association of the Pharmaceutical Industry)
- BRI Biopharmaceutical Research
- BTS Research
- Buffalo Institute for Genomics and Data Analytics (BIG)
- C&R Research
- C.RIS Pharma
- Calmark
- Cambrex Zenara (formerly known as Zenara Pharma)
- Cambridge Regulatory Services
- Carna Biosciences
- Cascade Chemistry
- Casma Therapeutics
- Catalent Pharma
- Catalyst Clinical Services
- CATO SMS
- CCDRD
- CCS Associates (CCSA)
- CD BioSciences
- Cedilla Therapeutics
- Celerion
- Center for Pharmacology and Analysis (CEPHA)
- Cerbios-Pharma
- Certara
- Certus International
- Charles River Laboratories
- CHDI Foundation
- Checkpoint Therapeutics
- ChemAxon
- ChemBio Discovery Solutions
- ChemBridge
- ChemDiv
- ChemModeling
- ChemoGenics BioPharma
- Chemotargets
- ChemPartner
- Chongqing Huapont Pharmaceutical
- CIRION
- Cliantha Research
- ClinAudits
- ClinBAY
- ClinChoice
- ClinDatrix
- Clinfinity
- Clinical Research Consulting
- Clinical Service Center (CSC)
- Clinical Trial Service (CTS)
- ClinicalConnection
- Clinilabs
- Clinipace
- CliniRx
- CLINTRIA
- Clinitude
- Clinlogix
- ClinMax
- Clinres Farmacija
- ClinServ
- ClinSmart
- ClinSoft
- Clinstat Consulting
- Clintec
- CluePoints
- CMIC Holdings
- CNS Contract Research
- CNS Pharmaceuticals
- Cohortias
- Colorado Computational
- Comac Medical
- ComInnex
- Commonwealth Biotechnologies
- Comparative Biosciences
- Concentrics Research
- Concept Life Sciences
- Confluence Discovery Technologies
- Confo Therapeutics
- Congenix
- Conifer Point Consulting
- Contract Pharmaceuticals
- Convex CRO
- CordenPharma
- CordenPharma
- CoreRx
- Corlexia Clinical Services
- CORONIS Research
- Covance
- CreaGen
- Creative Biostructure
- Credevo
- Crelux
- Cresset
- Criterium
- CRM-CRO
- Crocus Medical
- Cromos Pharma
- CROPRIME
- Crown CRO
- CTI
- CW Research & Management
- CytoAgents
- Cytovation
- Dabur Research Foundation (DRF)
- Dalriada Drug Discovery
- Dalton Pharma Services
- Datapharm
- DaVinci Biomedical Research Products
- DaVita Clinical Research
- Deshpande Laboratories
- dicentra
- Dimension Research
- Direct Biologics
- DIVERCHIM
- Divi's Laboratories
- Dizal Pharmaceutical
- dMed Biopharmaceutical
- DMPK4Biotech
- Domainex
- Dorian Therapeutics
- Double Bond Pharmaceutical
- DP Clinical
- DPT Laboratories
- Drik
- DRK Pharma Solutions
- DSK InnoSciences
- DSP Clinical Research
- DyNAbind
- DZS Clinical Services
- EDASA Scientific
- Edelris
- EGCP
- EGeen
- Emerson
- Emery Pharma
- EMINent Services
- Emissary International
- Enamine
- Epirium Bio
- Equinox Pharma
- Ergomed
- ERT
- ESTERN Medical CRO
- ethica CRO
- Eurofins Discovery
- Everest Clinical Research
- Evonik
- Evotec
- ExCellThera
- Excelya
- Experimentica
- Explora BioLabs
- Farmigea
- Farzan Clinical Research
- FGK Clinical Research
- First Clinical Research
- Flamma
- Forma Therapeutics
- Frontage Laboratories
- Galapagos
- Gavi
- GB Pharma
- Gedeon Richter
- Gencore BioPharma
- Genentech
- Genesis Drug Discovery & Development
- Genetron Holdings
- Genpro Research
- George Clinical
- GI Innovation
- GI Reviewers
- Gilead Sciences
- Global Center for Medical Innovation (GCMI)
- GMP Bio
- Gotham Therapeutics
- GP Pharm
- Grayline Research Center
- Green Cross Lab Cell
- GRK Research Laboratories
- GVK Biosciences
- H&J CRO International
- Hamamatsu Pharma Research (HPR)
- Harvis Pharm
- Health Decisions
- HealthCare Global Enterprises
- Highlight Therapeutics
- Hikma Pharmaceuticals
- Hippocrates Research (HR)
- HitGen
- Holburn Biomedical
- Hoth Therapeutics
- HungaroTrial
- Hurley Consulting Associates
- Hyperion Biotechnology
- ICON
- International Drug Development Institute (IDDI)
- IIT Delhi
- IKCON PHARMA
- Immunocure Discovery Solutions
- Imperial Clinical Research Services
- Imperial College London
- ImQuest BioSciences
- InCROM
- Indivirtus
- Info Kinetics
- InformedDNA
- IniXium
- Innovative Informatica Technologies
- Inotiv
- Inoviem
- Inspire
- Integral Biosciences
- Integrium
- InteRNA Technologies
- International Clinical Trials Association
- International HealthCare (IHC)
- Intonation Research Laboratories
- Intrials Clinical Research
- Invivoscribe
- IonsGate Preclincal Services
- IPS Therapeutique (IPST)
- IQVIA
- IRBM
- Iris Pharma
- IRW
- Isochem
- JANIX
- Janssen Biotech
- Jehangir Clinical Development Centre (JCDC)
- JOANNEUM RESEARCH
- JRF Global
- JSS Medical Research
- Jubilant Biosys
- Julius Clinical
- Kalexsyn
- KCAS Bioanalytical and Biomarker Services
- KCR
- Key Organics
- Klinar
- KMR Group
- KP Pharmaceutical Technology
- KPS Clinical Services
- Kriger Research International
- Kymera
- Lambda Therapeutics Research
- Lancaster University
- Laurus Synthesis
- LAVA Therapeutics
- LAXAI Life Sciences (a subsidiary of Laxai Pharma)
- LegoChem Biosciences (LCB)
- Leon Research
- LG Chem
- Liatris Biosciences
- Life Chemicals
- Linical
- LINK Medical
- Lipigon
- Liverpool ChiroChem
- Lonza
- Lotus Clinical Research
- Lotus Pharmaceuticals
- LSK Global Pharma Services
- Lubrizol Life Science (LLS Health)
- Lucid Diagnostics
- MakroCare
- Marksman Healthcare
- Mascot Industries
- MB Quest
- Medelis
- Medfiles
- Medi Service
- Medical Data Analytics (MDA)
- Medicilon
- Medicines Evaluation Unit (MEU)
- Medidata Solutions
- Mediolanum Cardio Research (MCR)
- Mediprobe Research
- Medis Research Group
- Medpace
- MedPharm
- MedReleaf
- MedTrials
- MENADIONA
- MENE Health Group (MHG)
- Merck & Co.
- Meruvax Pharma
- Metrics Champion Consortium (MCC)
- Metrics Contract Services
- Metrics Research
- Micar Innovation
- Micro Therapeutic Research Labs (MTRL)
- MicroConstants
- Micro-Sphere
- Mitsubishi Tanabe Pharma
- MLM Medical Labs
- MMS Holdings
- Molcan
- Molecular Cornerstones
- Molecular Forecaster
- Molecule CRO
- Molsoft
- Moncoa Medical Research
- Monipol
- Monitioring Force
- MonitorCRO
- Morley Research Consortium
- Morphic
- MRI Global
- MSN Laboratories
- MTZ Clinical Research
- My Green Lab
- Nagy Research
- Nanjing Pharmatechs
- Nanosyn
- Nanyang Technological University (NTU)
- National Cancer Institute
- NCGS
- Neurofit
- Neurosolutions
- New England Discovery Partners (NEDP)
- Next Pharma
- Nextar Chempharma Solutions
- NexusPharma
- NIAID
- Nitza Bioventure
- NMX Research and Solutions
- Noble Life Sciences
- NorthEast BioLab
- NorthWise Services
- Norwich Clinical Research Associates
- Nostrum Biodiscovery
- NovaData Solutions
- NovAlix
- NovaMechanics
- Novotech
- NTZ Lab
- NuChem Therapeutics
- Nutrasource
- Nuvisan Pharma
- OCT Clinical
- OMass Therapeutics
- Oncodesign
- Oncology Ventures
- ONCOtherapeutics
- Onq Research
- OpenEye Scientific
- Open Orphan
- Operatrix Consulting
- OPN Healthcare
- Ora Clinical
- Orbis Clinical
- Organo Chem
- Oroxcell
- Orphan Reach
- Osong
- OTAVA Chemicals
- P3 Research
- Pacific BioLabs
- Pacific Bridge Medical
- Palm Beach CRO
- Palobiofarma
- Paraxel
- Paraza Pharma
- Patheon by Thermo Fischer Scientific
- Peachtree BioResearch Solutions
- PELVIPHARM
- ProXyChem
- Pfizer CentreOne®
- Pharma Inventor
- Pharma Medica Research
- Pharmacelera
- Pharmaceuticals Product Development
- Pharmaffiliates
- Pharmahungary
- PharmAI
- Pharmalys
- PharmaResources
- Pharmaron
- PharmaSeek (acquired by WCG)
- Pharmatest Services
- Pharm-Olam
- PharmStats
- PharSafer®
- PHASTAR
- PHDS Healthcare Research
- Phoneix Clinical Research
- Physiogenex
- Pierrel SpA
- pilot Mainz
- Pion
- Piramal Pharma Solutions
- Pivotal
- POPSI CUBE
- Porton Fine Chemicals
- PPC Group
- PRA Health Sciences
- Premier Research
- Prestwick Chemical
- Princeton BioMolecular Research
- Procaps
- ProDERM
- Profacgen
- Profil
- Proinnovera
- Promedica International
- PROMETRIKA
- ProRelix Research
- Prosarix
- Proswell Medical
- Proteros Fragments
- ProtoQSAR
- Provid Pharmaceuticals
- Providence Clinical Research
- Proxima
- Proximagen
- ProXyChem
- ProZyme
- Prudentia Group
- PSI
- Pyramid Laboratories
- Pyxis Discovery
- QPS
- Q-Trials
- Quality Assistance
- Quality Chemical Laboratories
- Quanticate
- Quartesian
- Quay Pharmaceuticals
- Quotient Sciences
- Raptim Research
- RASA Lifescience Informatics
- Raybow Pharmaceuticals
- Reaction Biology
- Reaxense
- Recipharm
- Red Glead Discovery
- Redox Scientific
- Redoxis
- Reliance Life Sciences
- Research Assist
- Resolution Bioscience
- Resolution Latin America
- Rho
- Richmond Pharmacology
- Rottendorf Pharma
- RTI Health Solutions
- RTI International
- Sacura
- Sai Life Sciences
- Sambi Pharma
- Sandexis Molecular Design
- Sanjeevani Bio
- Sanofi
- Sarah Cannon Development Innovations
- SARomics Biostructures
- Scandinavian CRO
- Schiff & Company
- SchinoPharm
- Scian services
- Scientific Bio-minds
- Scimega
- SchinoPharm
- Scope International
- Sekisui Xenotech
- Selvita
- SGS Life Sciences
- SGS Life Sciences
- Shamrock Structures
- Siegfried
- SilcsBio
- SILLAR CLINICAL
- Simbec-Orion
- Simulations Plus
- Sinclair Research
- Sipra Labs
- SiREEN
- Sitryx Therapeutics
- SLG
- SLR Biosciences
- Smerud Medical Research Group
- Smerud Medical Research International
- SMO India
- SNBL Japan
- SoBran Bioscience
- SOCAR Research
- SofPromed
- Solvias
- SomaLogic
- Sovereign Pharmaceuticals
- Spaulding Clinical
- Spectrum Clinical Research
- Sphaera Pharma
- SpiroChem
- SPRI Ukraine
- Squarepoint-Pointcare
- Staidson
- Standard Medical Products
- Statistics Collaborative
- STATKING Clinical Services
- Stiris Research
- Strain Chem
- Strand Life Sciences
- Strategic Regulatory Consulting
- Structure Based Design
- Sugen Life Sciences
- Sun Pharma Advanced Research Company
- Sundia
- Sundia MediTech
- SuperLab
- Swiss Pharma
- Sygnature Discovery
- Symbio Research
- Symeres
- Symphony Pharma Life Science
- Synapse
- Synchron
- Syneos Health
- Synergy Research Group
- Syngene
- SynphaTec Japon
- SYNSIGHT
- Synteract
- SYNthesis med chem
- Syreon Clinical Research
- Sysdata Consulting
- T3D Therapeutics
- Takeda Pharmaceutical
- Target Health
- Taros Chemicals
- TCA Clinical Research
- TCG Lifesciences
- Tech Observer
- TFS HealthScience
- The Alliance for Clinical Trials in Oncology
- The Avoca Group
- The Kitasato Institute
- The Micron Group
- The Siesta Group
- The SIRO Clinpharm
- Theradex Oncology
- TheraIndx Lifesciences
- Therapeutics
- Tigermed
- TimTec
- Titan Pharma
- TKL Research
- TMG Research
- Tolmar
- Tonus-Les
- Torrent Pharm
- Toxikon
- TransPharm Preclinical Solutions
- Trennic Data Services
- Trifecta Clinical
- Tubilux Pharma (acquired by C.O.C Farmaceutici)
- ULTRA Scientific
- Ultratech India
- Unichem Laboratories
- Unimark Remedies
- Unison
- University of Edinburgh
- University of Manchester
- University of Sheffield
- UPM Pharmaceuticals
- UPPTHERA
- US Pharma Lab
- USV
- Vagdevi InnoScience
- Veeda CRO
- Velesco Pharmaceutical Services
- Velos
- Vergo Pharma Research
- Veristat
- Vernalis
- Verum Clinical Research
- Vimta Labs
- Vipergen
- Vipragen Biosciences
- Viva Biotech
- Vlife Sciences
- Vyome Therapeutics
- Waife & Associates
- WellSpring Consumer Healthcare
- Westat
- Wilmington PharmaTech
- Windlas
- Windlas Healthcare
- Winicker Norimed
- WCG IRB
- Wisdom Pharmaceuticals
- Worldwide Clinical Trials
- WuXi AppTec
- XoNovo
- Xpose Therapeutics
- Xtal BioStructures
- Yaadvi Scientific Solutions
- Yale University
- Yao Pharma
- Young In Scientific
- Yung Zip Chemical
- Zaggo
- Zambon
- ZEINCRO
- Zenith Healthcare
- Zenobia Fragments
- ZenRise
- Apeloa Pharma
- Zhejiang Langhua Pharmaceutical
- ZM Company
- ZoBio
- Zydus BSV Pharma
Methodology
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