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COVID-19: Epidemiology, Biochemistry, and Diagnostics

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    Book

  • September 2021
  • Bentham Science Publishers Ltd
  • ID: 5456772
COVID-19: Epidemiology, Biochemistry, and Diagnostics explains COVID-19 from multidisciplinary angles such as the evolution of SARS-COV, genetic techniques to study the virus, and diagnostic methodologies widely used in the global COVID-19 pandemic.

The chapters in this book provide the reader with up-to-date literature about research on SARS-CoV-2 through three parts:

I) Evolution and Entry of SARS-CoV-2 into the host
II) Genetic Alteration and Structural Determination of SARS-CoV-2 Proteins
III) Quantitative Analysis of SARS-CoV-2 for research and medical diagnosis

Key Features

  • 15 chapters on SAR-CoV-2 in a multidisciplinary context
  • Provides a comprehensive overview of SARS-CoV-2 evolution and genetics
  • Provides biochemical information about SARS-CoV-2 proteins and receptor targets (both structural and non-structural proteins)
  • Includes an overview of several methods of detecting SARS-CoV-2 virus particles (ELISA, PCR, Neutralizing Antibodies
  • Covers some critical diagnostic modalities for COVID-19 diagnosis
  • Provides bibliographic references for further reading

Readers will understand the significance of phylogenetic analysis of coronaviruses, along with the pathogenesis of COVID-19 and related diseases such as SARS and MERS. Applications of biochemical technologies such as RT-PCR and CRISPR are also demonstrated in the text. This book is a comprehensive introduction to COVID-19 research for medical researchers, microbiologists and virologists. Students in academic programs in life sciences and medicine will also benefit from the information provided in the book.

Table of Contents

PART 1 PART I: EVOLUTION AND ENTRY OF SARS-COV-2


  • Chapter 1 Coronavirus Disease-2019 (COVID- 19) Epidemiology
  • Chapter 2 Studying Evolutionary Adaptation of Sars-Cov-2
  • Chapter 3 Evaluating Sars-Cov-2 Entry Pathways

PART 2 PART II: GENETIC ALTERATION AND STRUCTURAL DETERMINATION OF SARS-COV-2 PROTEINS


  • Chapter 4 Genomic Characterization of Sars-Cov-2
  • Chapter 5 Mutation of Sars-Cov-2
  • Chapter 6 Biochemical Characterization of Sars-Cov-2 Spike Protein Proteolytic Processing
  • Chapter 7 Crystal Structure Determination and Receptor Recognition Basis of Sars-Cov-2 Spike Glycoprotein
  • Chapter 8 Structural Elucidation of Sars-Cov-2 Accessory Proteins

PART 3 PART III: QUANTITATION ANALYSIS OF SARS-COV-2


  • Chapter 9 Antigen Capture Enzyme-Linked Immunosorbent Assay (Elisa) for the Detection of the Novel Sars-Cov-2 in Humans
  • Chapter 10 Quantification of the Sars-Cov-2 Rna in Tissues by Quantitative Real Time-Pcr
  • Chapter 11 Evaluation of Sars-Cov-2 Neutralizing Antibodies in Sera Using Live Virus Microneutralization Assay
  • Chapter 12 Pseudovirus Neutralization Assay for Sars-Cov-
  • Chapter 13 Quantitative and Qualitative Determination of COVID-19 (Sars-Cov-2) Specific Antibodies Using Elisa
  • Chapter 14 Chest Ct Scan: An Ideal Diagnostic Tool for COVID-19
  • Chapter 15 Nucleic Acid-Based Detection of COVID-19

Subject Index


Author

  • Kamal Niaz
  • Muhammad Farrukh Nisar