Medical Marijuana - Cannabidiol - Pipeline Insight, 2024

This “Medical Marijuana - Cannabidiol - Pipeline Insight, 2024,” report provides comprehensive insights about 25+ companies and 50+ pipeline drugs in Medical Marijuana - Cannabidiol pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

• Global coverage

Medical Marijuana - Cannabidiol Understanding

Medical Marijuana - Cannabidiol: Overview

The term medical marijuana refers to using the whole, unprocessed marijuana plant or its basic extracts to treat symptoms of illness and other conditions. The U.S. Food and Drug Administration (FDA) has not recognized or approved the marijuana plant as medicine. However, the scientific study of the chemicals in marijuana, called cannabinoids, has led to some FDA-approved medications that contain cannabinoid chemicals in pill form. Continued research may lead to the approval of more medications. Since it contains chemicals it may help in treating a wide range of illnesses and symptoms; many people argue that it should be legal for medical purposes. A growing number of states have legalized marijuana for medical use. Medical marijuana is the medical use of Cannabis sativa or Cannabis indica plant to relieve symptoms of, or treat diseases and conditions. The increasing research on medical marijuana shows its therapeutic value for a range of health conditions, including chronic pain, cancer, arthritis, diabetes, depression, anxiety, and many more. Currently, the two main cannabinoids from the marijuana plant that are of medical interest are THC and CBD. THC can increase appetite and reduce nausea. THC may also decrease pain, inflammation (swelling and redness), and muscle control problems. Unlike THC, CBD is a cannabinoid that does not make people high. These drugs are not popular for recreational use because they are not intoxicating. It may be useful in reducing pain and inflammation, controlling epileptic seizures, and possibly even treating mental illness and addictions. The FDA approved a CBD-based liquid medication called Epidiolex for the treatment of two forms of severe childhood epilepsy, Dravet syndrome and Lennox-Gastaut syndrome.

Medical Marijuana - Cannabidiol - Pipeline Insight, 2024 report outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Medical Marijuana - Cannabidiol pipeline landscape is provided which includes the disease overview and Medical Marijuana - Cannabidiol treatment guidelines. The assessment part of the report embraces, in depth Medical Marijuana - Cannabidiol commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Medical Marijuana - Cannabidiol collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

Report Highlights

The companies and academics are working to assess challenges and seek opportunities that could influence Medical Marijuana - Cannabidiol R&D. The therapies under development are focused on novel approaches to treat/improve Medical Marijuana - Cannabidiol.

Medical Marijuana - Cannabidiol Emerging Drugs Chapters

This segment of the Medical Marijuana - Cannabidiol report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Medical Marijuana - Cannabidiol Emerging Drugs

BX-1: Bionorica SEBX-1 is an oral solution containing dronabinol, being developed by Bionorica. Dronabinol is a synthetic form of ??-THC, the primary psychoactive component of cannabis. The drug is currently in phase III stage of development for the treatment of spasticity in patients with multiple sclerosis not showing sufficient response to their current anti-spasticity treatment.

Lenabasum: Corbus Pharmaceuticals Corbus Pharmaceuticals is developing Lenabasum, and currently it is in phase III stage of development for the treatment of multiple indications, such as dermatomyositis, systemic scleroderma, cystic fibrosis, systemic lupus erythematosus etc. Lenabasum is a novel, oral, small molecule that selectively binds as an agonist to the cannabinoid receptor type 2 (CB2) and resolves inflammation and limits fibrosis in animal and human models of disease. CB2 is preferentially expressed on activated immune cells and on fibroblasts, muscle cells, and endothelial cells.

THX-110: Therapix Biosciences THX-110 is a being developed by Therapix Biosciences. The drug candidate platform is for the treatment of symptoms related to Tourette syndrome (TS), as well as obstructive sleep apnea (OSA) and chronic pain. Therapix is seeking orphan drug designation for this compound. The THX-110 program takes a unique approach to cannabinoid formulation using the Entourage Effect hypothesis (i.e., in which endocannabinoid system constituents work synergistically together). THX-110 is a proprietary combination drug based on dronabinol and PEA. The drug is currently in phase II stage ofdevelopment.

Cannabis oil: TO Pharmaceuticals TO Pharma is developing next-generation cannabinoid therapies for debilitating diseases. TO pharmaceuticals is developing Cannabis oil, and currently, it is in phase II stage of development for the treatment of hidradenitis suppurativa and agitation related to dementia. The cannabis oil is made out of extract from the Avidekel strain and olive oil. Avidekel oil containing ?9-Tetra-Hydrocannabinol (?9-THC) and Cannabidiol (CBD) in a 1:20 ratio and at a concentration of 30% CBD and 1.5% ?9-THC. Each Avidekel oil drop is approximately 0.04 mL in volume containing about 12 mg CBD and 0.6 mg ?9-THC. The oil is in the form of drops to be administered orally.

VSN16R: Canbex Therapeutics VSN16R is currently in phase II stage of development for the treatment of spasticity in people with multiple sclerosis. The orally active small molecule compound is being developed by Canbex Therapeutics, a spin-off of University College London (UCL). Preclinical and Phase I clinical studies have demonstrated that VSN16R has the potential to provide substantially better patient care than existing systemic anti-spastic treatments. VSN16R was shown to be safe and well-tolerated in its Phase I clinical safety trial. In the Phase I study, 72 healthy volunteers were enrolled in a placebo-controlled, single ascending- and multiple-ascending dose design.

INM-755: InMed Pharmaceuticals INM-755 is a cannabinol topical cream under development for the treatment of epidermolysis bullosa. INM-755 cream for EB is the first, and currently the only, cannabinol formulation being tested in clinical trials as a therapeutic product. The Phase 2 study, 755-201-EB, is designed to enroll up to 20 patients, conservatively within 10-12 months, and will take place at 10 pre-qualified clinical sites in several countries. All four subtypes of inherited EB, being EB Simplex, Dystrophic EB, Junctional EB, and Kindler Syndrome, are eligible for this study in which InMed will evaluate the safety of INM-755 (cannabinol) cream and its preliminary efficacy in treating symptoms and healing wounds over a 28-day period.

Medical Marijuana - Cannabidiol: Therapeutic Assessment

This segment of the report provides insights about the different Medical Marijuana - Cannabidiol drugs segregated based on following parameters that define the scope of the report, such as:

Major Players in Medical Marijuana - Cannabidiol

There are approx. 25+ key companies which are developing the therapies for Medical Marijuana - Cannabidiol. The companies which have their Medical Marijuana - Cannabidiol drug candidates in the most advanced stage, i.e. Phase III include, Bionorica SE.

Phases

This report covers around 50+ products under different phases of clinical development like

• Late stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates

Route of Administration

Medical Marijuana - Cannabidiol pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

• Oral
• Parenteral
• Intravenous
• Subcutaneous
• Topical.

Molecule Type

Products have been categorized under various Molecule types such as

• Monoclonal Antibody
• Peptides
• Polymer
• Small molecule
• Gene therapy

Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Medical Marijuana - Cannabidiol: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Medical Marijuana - Cannabidiol therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Medical Marijuana - Cannabidiol drugs.

Medical Marijuana - Cannabidiol Report Insights

• Medical Marijuana - Cannabidiol Pipeline Analysis
• Therapeutic Assessment
• Unmet Needs
• Impact of Drugs

Medical Marijuana - Cannabidiol Report Assessment

• Pipeline Product Profiles
• Therapeutic Assessment
• Pipeline Assessment
• Inactive drugs assessment
• Unmet Needs

Key Questions

Current Treatment Scenario and Emerging Therapies:

• How many companies are developing Medical Marijuana - Cannabidiol drugs?
• How many Medical Marijuana - Cannabidiol drugs are developed by each company?
• How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Medical Marijuana - Cannabidiol?
• What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Medical Marijuana - Cannabidiol therapeutics?
• What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
• What are the clinical studies going on for Medical Marijuana - Cannabidiol and their status?
• What are the key designations that have been granted to the emerging drugs?

Key Players

• Tetra Bio-Pharma
• Corbus Pharmaceuticals
• Bionorica SE
• e3D Pharma
• TO Pharmaceuticals
• Therapix Biosciences
• ANANDA Scientific
• Daisy Pharma Opioid Venture
• Canbex Therapeutics
• InMed Pharmaceuticals
• Botanix Pharmaceuticals
• Centrexion Therapeutics
• Tilray
• One World Cannabis
• Epm Group
• Zelira Therapeutics
• Pascal Biosciences
• Cannovex
• Can-Fite Pharma
• GB Sciences
• Serina Therapeutics
• Oxford Cannabinoid Technologies
• Cannabis Science

Key Products

• PPP011
• Lenabasum
• BX-1
• e3D-01
• e3D-03
• Cannabis Oil
• THX-110
• Nantheia A1002N5S
• Dronabinol
• VSN16R
• INM-755
• BTX 1503
• BTX1801
• CNTX-6016
• TN-TC11G
• OWC MGC cream
• BTX1702
• e3D-05
• EPM301

Research programme: Cancer therapeutics- Research programme: cannabinoid-based formulations

• PAS-403
• PAS-393
• Pascal Cannabinoid

Research programme: cannabidiol-combination therapies- Research programme: cannabidiol therapy
Research programme: Synthetic CBD analogs- Supera-CBD

• KLS-13019
• CNX-004
• CNX-005
• CNX-006
• INM-088
• A3AR-based Cannabis Compounds
• EPM302
• EPM305
• EPM306
• Cannabinoid containing complex mixtures (CCCM™)
• Cannabinoid-Based Medical Compound
• SER-228
• OCT461201
• CNX-001
• CNX-002
• CNX-003
• CS-S/BCC-1

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