This expert volume in the�Diagnostic Pathology�series is an�excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of splenic pathology, it incorporates the most recent clinical, pathologic, and molecular knowledge in this challenging field to provide a�comprehensive overview of all key issues�relevant to today's practice. Richly illustrated and easy to use, the 2nd edition of�Diagnostic Pathology: Spleen�is�a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource.
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Provides�essential knowledge focused entirely on splenic pathology, including immunohistochemistry, flow cytometry, and molecular testing as they relate to splenic lesions and their differential diagnoses�
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Presents�up-to-date information�on splenic injury and laceration grading and management, the findings of next-generation sequencing studies, and a range of molecularly defined genetic alterations of spleen neoplasms�
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Features an�Antibody Index�and�Molecular Factors Index�to assist with identification and diagnosis�
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Includes�14 new chapters�covering topics such as autoimmune disease involving the spleen, spleen anatomy, splenic microcirculation, immune function of the spleen, spleen imaging,�leukemic non-nodal mantle cell lymphoma, Tay-Sachs disease, normal T-cell subsets, and many others�
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Includes approximately�2,000 high-quality clinical and histologic images, gross pathology images, radiologic images, and full-color illustrations to help practicing and in-training pathologists reach a confident diagnosis�
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Includes�updated criteria, terminology, and classifications�from the 2017�World Health Organization Classification of Lymphoid Neoplasms��
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Employs consistently�templated chapters, bulleted content, key facts, and annotated images�for quick, expert reference at the point of care�
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Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices�
Table of Contents
SECTION 1: HISTOLOGY, FUNCTION, AND DEVELOPMENT OF SPLEENNORMAL HISTOLOGY
4 Introduction to Spleen
Mohammad A. Vasef, MD and Jeremy C. Wallentine, MD
12 Imaging of Splenic Disorders
Mohammad A. Vasef, MD
18 Handling, Processing, and Gross Pathology of Spleen
Mohammad A. Vasef, MD
26 Fine-Needle Aspiration and Core Biopsy of Spleen
Mohammad A. Vasef, MD
32 Immunohistochemistry of Spleen
Aaron Auerbach, MD, MPH
40 Flow Cytometry
Nadine Aguilera, MD
46 Molecular Techniques
Nadine Aguilera, MD
SECTION 2: NONNEOPLASTIC SPLENIC DISORDERS
LYMPHOID HYPERPLASIA
54 Florid Follicular Hyperplasia
Jeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH
56 Autoimmune Disease
Nadine Aguilera, MD
62 HIV in Spleen
Nadine Aguilera, MD
68 Castleman Disease
Nadine Aguilera, MD
70 Marginal Zone Hyperplasia
Jeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH
GRANULOMATOUS LESIONS/DISORDERS
72 Lipogranulomas
Jeffrey Vos, MD
78 Sarcoidosis
Ellina Hall, DO and Aaron Auerbach, MD, MPH
82 Chronic Granulomatous Disease
Aaron Auerbach, MD, MPH
INFECTIONS
86 Mycobacteriosis
Nadine Aguilera, MD
90 Selected Bacterial Infections
Aaron Auerbach, MD, MPH
94 Candidiasis
Aaron Auerbach, MD, MPH
96 Histoplasmosis
Nadine Aguilera, MD
98 Cryptococcosis
Nadine Aguilera, MD
100 Coccidioidomycosis
Aaron Auerbach, MD, MPH
104 Pneumocystosis
Aaron Auerbach, MD, MPH
108 Infectious Mononucleosis
Nadine Aguilera, MD
112 Cytomegalovirus Infection
Nadine Aguilera, MD
114 Herpes Simplex Virus Infection
Aaron Auerbach, MD, MPH and Nadine Aguilera, MD
116 Echinococcosis
Aaron Auerbach, MD, MPH
120 Malaria
Nadine Aguilera, MD
NONINFECTIOUS CYSTS
122 Epithelial Cyst
Ellina Hall, DO and Aaron Auerbach, MD, MPH
124 False Cyst
Ellina Hall, DO and Aaron Auerbach, MD, MPH
NONNEOPLASTIC VASCULAR PROCESSES
126 Chronic Passive Congestion
Ellina Hall, DO and Aaron Auerbach, MD, MPH
128 Infarct
Jeffrey Vos, MD
136 Peliosis
Ellina Hall, DO and Aaron Auerbach, MD, MPH
138 Sclerosing Angiomatoid Nodular Transformation Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD
RED CELL DISORDERS
144 Sickle Cell Disease
Aaron Auerbach, MD, MPH and Ellina Hall, DO
146 Thalassemia
Nadine Aguilera, MD and Aaron Auerbach, MD, MPH
150 Hereditary Spherocytosis
Nadine Aguilera, MD
152 Thrombotic Thrombocytopenic Purpura
Aaron Auerbach, MD, MPH
MISCELLANEOUS LESIONS/DISORDERS
158 Heterotaxy Syndromes
Aaron Auerbach, MD, MPH
160 Congenital Splenic Abnormalities
Nadine Aguilera, MD
164 Extramedullary Hematopoiesis
Ellina Hall, DO and Aaron Auerbach, MD, MPH
166 Gamna-Gandy Bodies
Nadine Aguilera, MD
168 Hemophagocytic Lymphohistiocytosis
Nadine Aguilera, MD
174 Immune Thrombocytopenic Purpura
Ellina Hall, DO and Aaron Auerbach, MD, MPH
178 Niemann-Pick Disease
Meenakshi A. Nandedkar, MD and Nadine Aguilera, MD
184 Gaucher Disease
Meenakshi A. Nandedkar, MD and Nadine Aguilera, MD
188 Sea-Blue (Ceroid) Histiocytosis
Mohammad A. Vasef, MD
192 Gangliosidosis Lysosomal Disorder
Mohammad A. Vasef, MD
194 Therapy Effect on Spleen
Aaron Auerbach, MD, MPH
202 Traumatic and Nontraumatic Splenic Injuries
Mohammad A. Vasef, MD
SECTION 3: NEOPLASTIC SPLENIC DISORDERS
BENIGN MESENCHYMAL LESIONS
208 Introduction to Vascular Lesions
Nadine Aguilera, MD
210 Hemangioma
Nadine Aguilera, MD
218 Lymphangioma
Nadine Aguilera, MD
222 Littoral Cell Angioma
Nadine Aguilera, MD
228 Inflammatory Pseudotumor
Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD
236 Postchemotherapy Histiocyte-Rich Pseudotumor of Spleen
Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD
242 Splenic Hamartoma
Nadine Aguilera, MD
246 Myelolipoma
Aaron Auerbach, MD, MPH
MALIGNANT OR POTENTIALLY MALIGNANT MESENCHYMAL LESIONS
248 Angiosarcoma
Nadine Aguilera, MD
256 Hemangioendothelioma
Nadine Aguilera, MD
258 Kaposi Sarcoma
Nadine Aguilera, MD
260 Leiomyosarcoma
Aaron Auerbach, MD, MPH
266 Gastrointestinal Stromal Tumor
Aaron Auerbach, MD, MPH
272 Follicular Dendritic Cell Sarcoma
Aaron Auerbach, MD, MPH
280 Inflammatory Pseudotumor-Like Follicular Dendritic Cell Sarcoma
Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD
286 Langerhans Cell Histiocytosis
Guanghua Wang, MD
292 Histiocytic Sarcoma
Nadine Aguilera, MD
LYMPHOMA
300 Introduction to Lymphoma
Mohammad A. Vasef, MD
310 Splenic Marginal Zone Lymphoma
Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD
318 Hairy Cell Leukemia
Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD
326 Hairy Cell Leukemia Variant
Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD
334 Lymphoplasmacytic Lymphoma
Aaron Auerbach, MD, MPH
342 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD
350 Follicular Lymphoma
Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD
358 Mantle Cell Lymphoma
Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD
366 Leukemic Nonnodal Mantle Cell Lymphoma
Mohammad A. Vasef, MD
370 Splenic Diffuse Red Pulp B-Cell Lymphoma
Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD
376 B-Cell Prolymphocytic Leukemia
Aaron Auerbach, MD, MPH and Nadine Aguilera, MD
378 Diffuse Large B-Cell Lymphoma
Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD
384 Fibrin-Associated Large B-Cell Lymphoma in Splenic False Cyst
Mohammad A. Vasef, MD
390 T-Cell/Histiocyte-Rich Large B-Cell Lymphoma
Jeffrey Vos, MD
398 Burkitt Lymphoma
Aaron Auerbach, MD, MPH
406 Classic Hodgkin Lymphoma
Jeffrey Vos, MD
416 Nodular Lymphocyte-Predominant Hodgkin Lymphoma
Aaron Auerbach, MD, MPH
426 Peripheral T-Cell Lymphoma, Unspecified
Mohammad A. Vasef, MD
432 Hepatosplenic T-Cell Lymphoma
Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD
440 T-Cell Prolymphocytic Leukemia
Mohammad A. Vasef, MD
448 T-Cell Large Granular Lymphocytic Leukemia
Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD
456 Aggressive NK-Cell Leukemia
Aaron Auerbach, MD, MPH
462 Transformation of Splenic Disorders
Nadine Aguilera, MD
LEUKEMIA
466 Acute Myeloid Leukemia
Nadine Aguilera, MD
474 Lymphoblastic Leukemia/Lymphoma
Nadine Aguilera, MD
CHRONIC MYELOPROLIFERATIVE NEOPLASMS/MYELODYSPLASTIC SYNDROMES
480 Myeloproliferative Neoplasm Overview
Nadine Aguilera, MD
482 Chronic Myeloid Leukemia, BCR::ABL1 Positive
Nadine Aguilera, MD
488 Essential Thrombocythemia
Jeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH
492 Polycythemia Vera
Guanghua Wang, MD
496 Primary Myelofibrosis
Jeffrey Vos, MD
506 Mastocytosis
Mohammad A. Vasef, MD
514 Chronic Myelomonocytic Leukemia
Mohammad A. Vasef, MD
PLASMA CELL-ASSOCIATED DISORDERS
520 Amyloidosis
Nadine Aguilera, MD
526 Heavy Chain Disease
Aaron Auerbach, MD, MPH
530 Plasma Cell Myeloma/Plasmacytoma
Nadine Aguilera, MD and Aaron Auerbach, MD, MPH
METASTASIS
534 Metastatic Tumors
Ellina Hall, DO and Aaron Auerbach, MD, MPH
